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100 Fifth Ave 4,222 - 77,818 SF of Office Space Available in Waltham, MA 02451
Sublease Highlights
- LEED Gold Certified office building with sustainable systems and energy efficiency.
- Surrounded by quality hotels, dining, retail, and fitness amenities within walking distance.
- Multi-tenant design supports flexible build-outs and immediate occupancy options.
- Conveniently positioned along Route 128/I-95 with direct access to I-90 and Greater Boston’s business network.
- Part of a highly regarded corporate park serving major tech and life sciences companies.
All Available Spaces(5)
Display Rental Rate as
- Space
- Size
- Term
- Rental Rate
- Space Use
- Build-Out
- Available
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Central Air and Heating
- LEED Gold certified sustainable Class A building
- Flexible layouts with immediate availability
- Fully Built-Out as Standard Office
- Wheelchair Accessible
- Easy access to Route 128 and Mass Pike (I-90)
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Mostly Open Floor Plan Layout
- Wheelchair Accessible
- Easy access to Route 128 and Mass Pike (I-90)
- Fully Built-Out as Standard Office
- Central Air and Heating
- LEED Gold certified sustainable Class A building
- Flexible layouts with immediate availability
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Office intensive layout
- Central Air and Heating
- Fully Built-Out as Standard Office
- Partitioned Offices
- Wheelchair Accessible
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Mostly Open Floor Plan Layout
- Central Air and Heating
- LEED Gold certified sustainable Class A building
- Flexible layouts with immediate availability
- Fully Built-Out as Standard Office
- Partitioned Offices
- Wheelchair Accessible
- Easy access to Route 128 and Mass Pike (I-90)
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Open Floor Plan Layout
- Wheelchair Accessible
- Easy access to Route 128 and Mass Pike (I-90)
- Fully Built-Out as Standard Office
- Central Air and Heating
- LEED Gold certified sustainable Class A building
- Flexible layouts with immediate availability
| Space | Size | Term | Rental Rate | Space Use | Build-Out | Available |
| Lower Level | 4,222 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office | Full Build-Out | Now |
| 3rd Floor | 22,600 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office | Full Build-Out | Now |
| 5th Floor | 11,856 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office | Full Build-Out | Now |
| 6th Floor | 21,000 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office | Full Build-Out | Now |
| 7th Floor | 18,140 SF | Negotiable | Upon Request Upon Request Upon Request Upon Request | Office | Full Build-Out | Now |
Lower Level
| Size |
| 4,222 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
3rd Floor
| Size |
| 22,600 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
5th Floor
| Size |
| 11,856 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
6th Floor
| Size |
| 21,000 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
7th Floor
| Size |
| 18,140 SF |
| Term |
| Negotiable |
| Rental Rate |
| Upon Request Upon Request Upon Request Upon Request |
| Space Use |
| Office |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
Lower Level
| Size | 4,222 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office |
| Build-Out | Full Build-Out |
| Available | Now |
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Fully Built-Out as Standard Office
- Central Air and Heating
- Wheelchair Accessible
- LEED Gold certified sustainable Class A building
- Easy access to Route 128 and Mass Pike (I-90)
- Flexible layouts with immediate availability
3rd Floor
| Size | 22,600 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office |
| Build-Out | Full Build-Out |
| Available | Now |
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Central Air and Heating
- Wheelchair Accessible
- LEED Gold certified sustainable Class A building
- Easy access to Route 128 and Mass Pike (I-90)
- Flexible layouts with immediate availability
5th Floor
| Size | 11,856 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office |
| Build-Out | Full Build-Out |
| Available | Now |
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Fully Built-Out as Standard Office
- Office intensive layout
- Partitioned Offices
- Central Air and Heating
- Wheelchair Accessible
6th Floor
| Size | 21,000 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office |
| Build-Out | Full Build-Out |
| Available | Now |
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Fully Built-Out as Standard Office
- Mostly Open Floor Plan Layout
- Partitioned Offices
- Central Air and Heating
- Wheelchair Accessible
- LEED Gold certified sustainable Class A building
- Easy access to Route 128 and Mass Pike (I-90)
- Flexible layouts with immediate availability
7th Floor
| Size | 18,140 SF |
| Term | Negotiable |
| Rental Rate | Upon Request |
| Space Use | Office |
| Build-Out | Full Build-Out |
| Available | Now |
100 Fifth Avenue offers a rare block of contiguous, ready-to-occupy Class A space in one of Greater Boston's most sought-after suburban locations. A new tenant can take a single floor or assemble up to 77,818 rentable square feet across the building — an efficient, move-in-ready footprint with the infrastructure and amenities of a full corporate campus already in place. Whether you're consolidating, expanding, or relocating from the city, this is space that lets you scale on your terms.
- Sublease space available from current tenant
- Fully Built-Out as Standard Office
- Open Floor Plan Layout
- Central Air and Heating
- Wheelchair Accessible
- LEED Gold certified sustainable Class A building
- Easy access to Route 128 and Mass Pike (I-90)
- Flexible layouts with immediate availability
Property Overview
Fifth Avenue at CityPoint offers premium Class A office space in Waltham’s vibrant Highlands neighborhood, within the heart of Greater Boston’s dynamic Route 128 technology corridor. This professionally managed property provides modern, adaptable layouts suitable for a range of corporate users, backed by sustainable design with LEED Gold certification and abundant natural light throughout. The campus-style setting ensures convenient on-site amenities, expansive parking, and immediate access to major commuting routes. Tenants benefit from adjacency to Prospect Hill Lane’s business ecosystem, with proximity to major corporate headquarters, lodging accommodations, and top-tier dining options that support a strong workplace environment. Located just minutes from Interstates 95/Route 128 and the Massachusetts Turnpike (I-90), the property offers excellent regional connectivity for Boston and suburban workforce access. With commuter rail stations nearby and Logan International Airport within a 30-minute drive, tenants enjoy exceptional transportation advantages in a thriving professional hub that continues to attract technology, life sciences, and service-based firms.
- Atrium
- Convenience Store
- Day Care
- Fitness Center
- Food Court
- Property Manager on Site
- Security System
- Energy Star Labeled
- Wheelchair Accessible
- Monument Signage
- Balcony
Property Facts
Select Tenants
- Floor
- Tenant Name
- Industry
- Multiple
- Apellis
- Professional, Scientific, and Technical Services
- 5th
- Arm
- Manufacturing
- 4th
- Axtria Inc.
- Professional, Scientific, and Technical Services
- 1st
- Cogent Communications
- Information
- Multiple
- Convergent Dental
- Manufacturing
- 4th
- Sironax
- Professional, Scientific, and Technical Services
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100 Fifth Ave
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