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Highlights

  • Highly visible position along U.S. Highway 281 with direct access and strong signage opportunities.
  • Ample parking options, including both surface and covered spaces for patients and staff.
  • Convenient connectivity to Loop 1604, Interstate 410, and numerous residential communities.
  • Modernized medical office interiors supporting professional build-out requirements.
  • Located minutes from major hospitals, specialty providers, and retail amenities.
  • In a strong healthcare corridor with established patient base and growing demographics.

All Available Spaces(4)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 1st Floor, Ste 100
  • 2,720 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Partial Build-Out
  • Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Space is in Excellent Condition
  • Modernized medical office interiors
  • In a strong healthcare corridor
  • Mostly Open Floor Plan Layout
  • Highly visible position along U.S. Highway 281
  • Ample parking options
  • 1st Floor, Ste 125
  • 2,937 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Partial Build-Out
  • Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Space is in Excellent Condition
  • Modernized medical office interiors
  • In a strong healthcare corridor
  • Mostly Open Floor Plan Layout
  • Highly visible position along U.S. Highway 281
  • Ample parking options
  • 1st Floor, Ste 180
  • 1,798 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Partial Build-Out
  • Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Space is in Excellent Condition
  • Modernized medical office interiors
  • In a strong healthcare corridor
  • Mostly Open Floor Plan Layout
  • Highly visible position along U.S. Highway 281
  • Ample parking options
  • 2nd Floor, Ste 245
  • 2,729 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Partial Build-Out
  • Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Space is in Excellent Condition
  • Modernized medical office interiors
  • In a strong healthcare corridor
  • Mostly Open Floor Plan Layout
  • Highly visible position along U.S. Highway 281
  • Ample parking options
Space Size Term Rental Rate Space Use Build-Out Available
1st Floor, Ste 100 2,720 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Partial Build-Out Now
1st Floor, Ste 125 2,937 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Partial Build-Out Now
1st Floor, Ste 180 1,798 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Partial Build-Out Now
2nd Floor, Ste 245 2,729 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Partial Build-Out Now

1st Floor, Ste 100

Size
2,720 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Partial Build-Out
Available
Now

1st Floor, Ste 125

Size
2,937 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Partial Build-Out
Available
Now

1st Floor, Ste 180

Size
1,798 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Partial Build-Out
Available
Now

2nd Floor, Ste 245

Size
2,729 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Partial Build-Out
Available
Now

1st Floor, Ste 100

Size 2,720 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Partial Build-Out
Available Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
  • Highly visible position along U.S. Highway 281
  • Modernized medical office interiors
  • Ample parking options
  • In a strong healthcare corridor

1st Floor, Ste 125

Size 2,937 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Partial Build-Out
Available Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
  • Highly visible position along U.S. Highway 281
  • Modernized medical office interiors
  • Ample parking options
  • In a strong healthcare corridor

1st Floor, Ste 180

Size 1,798 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Partial Build-Out
Available Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
  • Highly visible position along U.S. Highway 281
  • Modernized medical office interiors
  • Ample parking options
  • In a strong healthcare corridor

2nd Floor, Ste 245

Size 2,729 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Partial Build-Out
Available Now

One Medical Park offers a premier Class A medical office environment located in one of San Antonio’s most established healthcare corridors. Featuring exceptional visibility from U.S. Highway 281, the building positions healthcare providers for strong brand exposure and convenience. The recently renovated interiors create a modern, efficient space designed for a wide range of medical and professional uses. The property provides ample surface and covered parking for patients and practitioners, ensuring ease of access. Surrounding hospitals, specialty clinics, and established healthcare practices make this a highly desirable location for medical professionals. Tenants will benefit from proximity to Loop 1604, Interstate 410, and the thriving residential communities of the North Central submarket. With strong demographics and significant daily traffic counts, One Medical Park delivers a compelling opportunity for practices seeking a well-connected, accessible setting in San Antonio’s healthcare hub.

  • Partially Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
  • Highly visible position along U.S. Highway 281
  • Modernized medical office interiors
  • Ample parking options
  • In a strong healthcare corridor

Property Overview

One Medical Park is an approximately 34,164-square-foot, two-story medical office building located at 14615 San Pedro Avenue just off U.S. Highway 281 in San Antonio’s North Central submarket. The property is near Loop 1604 and Interstate 410, providing regional access. Surrounding land uses include medical facilities, retail centers, and residential neighborhoods. The property offers surface parking and is positioned within a concentration of healthcare services and hospitals in the Stone Oak and North Central areas.

  • 24 Hour Access
  • Bus Line
  • Signage
  • Wheelchair Accessible
  • Wi-Fi
  • Monument Signage
  • Air Conditioning
  • Smoke Detector

Property Facts

Building Type
Office
Year Built
1986
Building Height
2 Stories
Building Size
34,164 SF
Building Class
B
Typical Floor Size
17,082 SF
Unfinished Ceiling Height
12’
Parking
118 Surface Parking Spaces
9 Covered Parking Spaces

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 2nd
  • Apex Allergy & Asthma
  • Health Care and Social Assistance
  • 1st
  • Clinical Pathology Laboratories
  • Health Care and Social Assistance
  • 1st
  • Elevate Health Clinics
  • Health Care and Social Assistance
  • 2nd
  • Gregory Thompson, MD
  • Health Care and Social Assistance
  • 2nd
  • Rheumatology Institute of San Antonio
  • Health Care and Social Assistance
  • 1st
  • San Antonio Podiatry Associates
  • Health Care and Social Assistance
  • 2nd
  • Tyler Family Practice
  • Health Care and Social Assistance
  • 2nd
  • University Health System
  • Health Care and Social Assistance
  • 1st
  • University Health Women's Heart Center-one Medical
  • Health Care and Social Assistance
Fairly walkable
50/100
Exceptionally drivable
90/100
Limited public transit
30/100
Fairly bikeable
40/100
  • Listing ID: 40955001

  • Date on Market: 2026-06-17

  • Last Updated:

  • Address: 14615 San Pedro Ave, San Antonio, TX 78232

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