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All Available Space(1)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 3rd Floor
  • 10,150 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

This 10,150 SF third-floor lab and office opportunity delivers a highly functional, turnkey environment designed to support a wide range of research and innovation uses. The space features a flexible layout with multiple lab areas, and existing infrastructure including compressed air and vacuum systems. Tenants benefit from robust building systems, including emergency backup power, ensuring operational continuity for critical functions. Beyond the lab, the building offers a best-in-class amenity package to support employee productivity and well-being. On-site features include a café serving breakfast and lunch, a fully equipped fitness center with locker rooms and towel service, and outdoor seating areas for collaboration or relaxation. An attached covered parking garage and additional surface parking provide convenience, while access to “The Grid” shuttle offers seamless connectivity to Alewife and surrounding areas. Located within a dynamic neighborhood cluster, 275 Second Avenue provides immediate access to Waltham’s thriving biotech and technology community, along with nearby retail and dining option

  • Lease rate does not include utilities, property expenses or building services
  • Mostly Open Floor Plan Layout
  • Fully Built-Out as Standard Office
Space Size Term Rental Rate Space Use Build-Out Available
3rd Floor 10,150 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now

3rd Floor

Size
10,150 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Full Build-Out
Available
Now

3rd Floor

Size 10,150 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Full Build-Out
Available Now

This 10,150 SF third-floor lab and office opportunity delivers a highly functional, turnkey environment designed to support a wide range of research and innovation uses. The space features a flexible layout with multiple lab areas, and existing infrastructure including compressed air and vacuum systems. Tenants benefit from robust building systems, including emergency backup power, ensuring operational continuity for critical functions. Beyond the lab, the building offers a best-in-class amenity package to support employee productivity and well-being. On-site features include a café serving breakfast and lunch, a fully equipped fitness center with locker rooms and towel service, and outdoor seating areas for collaboration or relaxation. An attached covered parking garage and additional surface parking provide convenience, while access to “The Grid” shuttle offers seamless connectivity to Alewife and surrounding areas. Located within a dynamic neighborhood cluster, 275 Second Avenue provides immediate access to Waltham’s thriving biotech and technology community, along with nearby retail and dining option

  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout

Property Overview

The Property has exceptional physical characteristics that are uniquely suited for life science. The building is situated in a transformed location with a wealth of amenities including the adjacent hotel, and numerous restaurants and entertainment venues. With an impressive tenant base and bordered by the world’s leading lab companies, the Property is in a unique position to capture the strong life science demand in Greater Boston. LAB & SUITE DETAILS: • Histology Lab with 6' chemical fume hood (CFH) • Tissue Culture (TC) Lab • Engineering Lab with dual anteroom access • Two (2) Laser Labs • Four (4) private offices plus CEO suite • Open office area, shared office, and huddle room • Conference room, reception, and break room with pantry • Dedicated server room • Shipping/receiving with freight elevator access

  • Bio-Tech/ Lab Space
  • Bus Line
  • Controlled Access
  • Fitness Center
  • Food Service
  • Metro/Subway
  • Restaurant
  • Security System
  • Signage
  • Storage Space
  • Outdoor Seating
  • Air Conditioning

Property Facts

Building Type
Office
Year Built/Renovated
2000/2019
LoopNet Rating
4 Star
Building Height
4 Stories
Building Size
106,654 SF
Building Class
A
Typical Floor Size
26,250 SF
Unfinished Ceiling Height
11’
Parking
100 Surface Parking Spaces
580 Covered Parking Spaces

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 2nd
  • Alloy Therapeutics, Inc
  • Manufacturing
  • 3rd
  • Blossom Innovations
  • Professional, Scientific, and Technical Services
  • 1st
  • Violin Systems
  • Manufacturing
  • Multiple
  • Visterra
  • Manufacturing
Fairly walkable
50/100
Exceptionally drivable
100/100
Limited public transit
30/100
Moderately bikeable
60/100
  • Listing ID: 39905933

  • Date on Market: 2026-03-25

  • Last Updated:

  • Address: 275 Second Ave, Waltham, MA 02451

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