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Sublease Highlights

  • Existing life science infrastructure includes biology, chemistry, and tissue culture laboratories.
  • Building supported by a 4,000-amp electrical system and emergency generator.
  • Executive offices, conference facilities, and collaborative work areas are built out.
  • Located within South San Francisco's established biotechnology corridor.

All Available Spaces(3)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 1st Floor
  • 33,636 SF
  • Jul 2031
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Full Build-Out
  • Now

The first floor features a laboratory-focused layout

  • Sublease space available from current tenant
  • Laboratory
  • 2 Workstations
  • 1 Conference Room
  • 2 Private Offices
  • Mostly Open Floor Plan Layout
  • Finished Ceilings: 11’
  • 3rd Floor
  • 33,635 SF
  • Jul 2031
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

The third floor offers a corporate office environment with 27 private offices, 11 conference rooms, open office areas, collaboration space, wellness rooms, phone rooms, huddle rooms, a public house break room, and supporting storage and technology areas

  • Sublease space available from current tenant
  • Mostly Open Floor Plan Layout
  • 27 Private Offices
  • 90 Workstations
  • Fully Built-Out as Standard Office
  • Fits 85 - 270 People
  • 11 Conference Rooms
  • Finished Ceilings: 11’
  • 4th Floor
  • 33,635 SF
  • Jul 2031
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Full Build-Out
  • Now

The fourth floor includes executive offices, private offices, open work areas, board rooms, conference rooms, team rooms, phone rooms, wellness space, huddle rooms, a work room, break room, and terrace access, creating a balanced executive and collaborative workplace environment.

  • Sublease space available from current tenant
  • Mostly Open Floor Plan Layout
  • Space is in Excellent Condition
  • Fully Built-Out as Standard Office
  • Fits 85 - 270 People
Space Size Term Rental Rate Space Use Build-Out Available
1st Floor 33,636 SF Jul 2031 Upon Request Upon Request Upon Request Upon Request Flex Full Build-Out Now
3rd Floor 33,635 SF Jul 2031 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now
4th Floor 33,635 SF Jul 2031 Upon Request Upon Request Upon Request Upon Request Office Full Build-Out Now

1st Floor

Size
33,636 SF
Term
Jul 2031
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Build-Out
Full Build-Out
Available
Now

3rd Floor

Size
33,635 SF
Term
Jul 2031
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Full Build-Out
Available
Now

4th Floor

Size
33,635 SF
Term
Jul 2031
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Full Build-Out
Available
Now

1st Floor

Size 33,636 SF
Term Jul 2031
Rental Rate Upon Request
Space Use Flex
Build-Out Full Build-Out
Available Now

The first floor features a laboratory-focused layout

  • Sublease space available from current tenant
  • 2 Private Offices
  • Laboratory
  • Mostly Open Floor Plan Layout
  • 2 Workstations
  • Finished Ceilings: 11’
  • 1 Conference Room

3rd Floor

Size 33,635 SF
Term Jul 2031
Rental Rate Upon Request
Space Use Office
Build-Out Full Build-Out
Available Now

The third floor offers a corporate office environment with 27 private offices, 11 conference rooms, open office areas, collaboration space, wellness rooms, phone rooms, huddle rooms, a public house break room, and supporting storage and technology areas

  • Sublease space available from current tenant
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Fits 85 - 270 People
  • 27 Private Offices
  • 11 Conference Rooms
  • 90 Workstations
  • Finished Ceilings: 11’

4th Floor

Size 33,635 SF
Term Jul 2031
Rental Rate Upon Request
Space Use Office
Build-Out Full Build-Out
Available Now

The fourth floor includes executive offices, private offices, open work areas, board rooms, conference rooms, team rooms, phone rooms, wellness space, huddle rooms, a work room, break room, and terrace access, creating a balanced executive and collaborative workplace environment.

  • Sublease space available from current tenant
  • Fully Built-Out as Standard Office
  • Mostly Open Floor Plan Layout
  • Fits 85 - 270 People
  • Space is in Excellent Condition

Property Overview

331 Oyster Point Boulevard is a 100,905-square-foot divisible building in South San Francisco. The property includes laboratory and office improvements across multiple floors. Existing improvements include chemistry laboratories, biology laboratories, tissue culture areas, vivarium space, conference rooms, private offices, open office areas, collaboration spaces, and support facilities. The building is served by a 4,000-amp three-phase electrical system and a 1,250 KVA emergency generator.

Property Facts

Building Type
Office
Year Built
2008
LoopNet Rating
4 Star
Building Height
4 Stories
Building Size
134,237 SF
Building Class
A
Typical Floor Size
33,559 SF
Unfinished Ceiling Height
11’
Parking
120 Surface Parking Spaces
210 Covered Parking Spaces

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • Multiple
  • Pliant Therapeutics
  • Professional, Scientific, and Technical Services
Fairly walkable
40/100
Exceptionally drivable
100/100
Some public transit
40/100
Moderately bikeable
70/100
  • Listing ID: 37024053

  • Date on Market: 2026-08-28

  • Last Updated:

  • Address: 331 Oyster Point Blvd, South San Francisco, CA 94080

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