40 Jessie St 49,560 SF Office Building San Francisco, CA 94105 For Sale

40 Jessie Street is a meticulously renovated boutique Lab, Office, and R&D asset located in the heart of San Francisco’s highly coveted Transbay District. Originally built in 1913 and transformed through major modernization efforts in 2006, 2017, and ongoing improvements, the property now serves as a mission-critical hub for Google’s Fitbit and wearables division. Spanning six stories with a full lower level, the building delivers a rare combination of historic character, state-of-the-art laboratory infrastructure, and creative office environments.
The property is fully leased to Google through December 2030, supported by an exceptional credit profile and more than thirteen million dollars invested in building systems, specialty labs, and workplace enhancements since 2017. This includes advanced chemistry and biology laboratories with full biosafety infrastructure, hardware labs, X-ray facilities, phlebotomy spaces, testing areas, and dedicated R&D suites designed to support Google’s technology development pipeline. Complementing this technical capacity are creative office floors, employee workspaces, collaboration zones, and premium tenant amenities such as a mezzanine lounge, multiple kitchens, showers and locker rooms, and a private outdoor deck offering sweeping city views.
40 Jessie is the only fully equipped, modern lab facility in downtown San Francisco, offering immediate proximity to Salesforce Park, Market Street, BART, and the Transbay Transit Center. With its irreplaceable location, specialty infrastructure, and corporate tenancy, the property stands as a unique urban R&D outpost combining premier functionality, connectivity, and long-term stability.