445-447 S Main St 12,630 SF Retail Building North Syracuse, NY 13212 For Sale

Hilco Global is accepting offers on this newly renovated commercial building.
445-447 South Main Street in North Syracuse, New York, offers a recently renovated, free-standing retail/medical office building designed to accommodate plasma donation operations or other healthcare-related uses. Originally constructed in 1954 and fully modernized in 2024, the property features upgraded infrastructure and systems to meet stringent operational and regulatory requirements, providing a turnkey solution for medical or specialty service providers.
The property is strategically located along a major thoroughfare and benefits from strong visibility and accessibility. It is bordered by two major roadways and offers convenient access to regional interstates, including I-81, I-481 and I-90, ensuring excellent connectivity to surrounding communities and regional destinations.
Situated on a 1.18-acre parcel, the site provides ample surface parking and four dedicated site access points, supporting efficient traffic flow for staff and visitors. The C-2 zoning designation allows for a wide range of adaptive reuse opportunities, including urgent care, outpatient services or other medically oriented applications.
This asset represents an attractive acquisition for investors or operators seeking a fully renovated, high-quality facility in a well-connected market with strong healthcare demand and long-term growth potential.

This building is part of a seven-property portfolio consisting of six newly constructed or fully renovated facilities and one land parcel. Strategically located across five states—Georgia, Illinois, Michigan, New York and North Carolina—these properties represent a unique opportunity to acquire modern, medically-oriented buildings suitable for a wide range of adaptive reuses. All properties can be acquired individually, together or in any combination.
Each facility was purpose-built or extensively renovated to meet the operational and regulatory requirements of a plasma donation center, featuring cold storage, enhanced power, plumbing, HVAC and life-safety systems. The sites are all high-visibility, freestanding locations within established retail or medical corridors, surrounded by complementary commercial activity and strong local demographics.
The portfolio is being delivered vacant, providing investors with immediate flexibility to re-tenant, repurpose or reposition the assets for continued medical use, healthcare-adjacent operations or traditional retail and commercial redevelopment. The properties’ size, layout and infrastructure also make them attractive for urgent care, diagnostics, community health or outpatient clinic conversions.