450 Melwood Ave 12,898 SF of Office/Medical Space Available in Pittsburgh, PA 15213

450 Melwood Avenue offers a premier mixed-use opportunity in the heart of North Oakland, one of Pittsburgh’s most dynamic hubs for innovation, technology, and medical advancement. The property is being reimagined as a distinctive landmark combining upscale residential living with modern commercial space. The lower level features 12,898 usable square feet of adaptable shell space that can be delivered as-is, subdivided, and fully built out to tenant specifications based on lease terms. Ideal for tech, robotics, research, creative office use, or storage the space offers flexibility to meet a range of commercial needs. The space is made accessible via two elevators (freight and passenger) along with an entrance through the main lobby on Melwood Ave and a lower level entrance at the rear of the building at the parking deck Above, the upper floors are being thoughtfully transformed into 42 boutique-style apartments, blending modern design with high-end finishes to create an elevated living experience in a well-connected urban setting. Strategically positioned within minutes of UPMC, Carnegie Mellon University, and the University of Pittsburgh, 450 Melwood benefits from exceptional proximity to world-class institutions, research centers, and an extensive network of medical and tech employers. With strong visibility and accessibility to major city arteries, this mixed-use redevelopment presents a rare opportunity to locate within the core of Pittsburgh’s innovation corridor.