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Highlights

  • Flexible life science, office, or R&D environment with divisibility options.
  • Existing 900-amp electrical service with approved expansion capacity.
  • Convenient access to Highway 101, Caltrain, ferry service, and SFO.
  • Tenant-improvement-ready opportunity with most equipment removed.
  • Ample on-site parking including 30 covered parking spaces.
  • Located within South San Francisco's established innovation corridor.

Features

Drive In Bays
1
Standard Parking Spaces
70

All Available Spaces(3)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • Ground
  • 2,903 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Flex
  • Full Build-Out
  • Now
  • Can be combined with additional space(s) for up to 44,311 SF of adjacent space
  • Secure Storage
  • 2nd Floor
  • 20,704 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Partial Build-Out
  • Now
  • Partially Built-Out as Research and Development Space
  • 18 Private Offices
  • 21 Workstations
  • Reception Area
  • Private Restrooms
  • Shower Facilities
  • Fits 52 - 166 People
  • 3 Conference Rooms
  • Can be combined with additional space(s) for up to 44,311 SF of adjacent space
  • Laboratory
  • Secure Storage
  • 3rd Floor
  • 20,704 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • Partial Build-Out
  • Now
  • Partially Built-Out as Research and Development Space
  • 21 Private Offices
  • 28 Workstations
  • Laboratory
  • Fits 52 - 166 People
  • 1 Conference Room
  • Can be combined with additional space(s) for up to 44,311 SF of adjacent space
  • Private Restrooms
Space Size Term Rental Rate Space Use Build-Out Available
Ground 2,903 SF Negotiable Upon Request Upon Request Upon Request Upon Request Flex Full Build-Out Now
2nd Floor 20,704 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Partial Build-Out Now
3rd Floor 20,704 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office Partial Build-Out Now

Ground

Size
2,903 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Flex
Build-Out
Full Build-Out
Available
Now

2nd Floor

Size
20,704 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Partial Build-Out
Available
Now

3rd Floor

Size
20,704 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
Partial Build-Out
Available
Now

Ground

Size 2,903 SF
Term Negotiable
Rental Rate Upon Request
Space Use Flex
Build-Out Full Build-Out
Available Now

  • Can be combined with additional space(s) for up to 44,311 SF of adjacent space
  • Secure Storage

2nd Floor

Size 20,704 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Partial Build-Out
Available Now

  • Partially Built-Out as Research and Development Space
  • Fits 52 - 166 People
  • 18 Private Offices
  • 3 Conference Rooms
  • 21 Workstations
  • Can be combined with additional space(s) for up to 44,311 SF of adjacent space
  • Reception Area
  • Laboratory
  • Private Restrooms
  • Secure Storage
  • Shower Facilities

3rd Floor

Size 20,704 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out Partial Build-Out
Available Now

  • Partially Built-Out as Research and Development Space
  • Fits 52 - 166 People
  • 21 Private Offices
  • 1 Conference Room
  • 28 Workstations
  • Can be combined with additional space(s) for up to 44,311 SF of adjacent space
  • Laboratory
  • Private Restrooms

Property Overview

468 Littlefield Avenue presents a rare opportunity to lease a full-building life science, research and development, or office facility in South San Francisco, one of the Bay Area's most established biotechnology and innovation corridors. The property consists of approximately 44,311 square feet across three levels and offers flexibility for a wide range of occupiers seeking laboratory support, research operations, office headquarters, or technology-focused workspace. The building is offered with most equipment removed and is positioned as a tenant-improvement-ready opportunity, allowing users to customize the environment to meet operational requirements. Existing infrastructure includes substantial electrical capacity with a current 900-amp service supported by a 750 KVA transformer, along with PG&E-approved capacity for future expansion to 3,000 amps. Building systems include multiple boilers, chillers, air handling units, and exhaust systems that support demanding operational requirements. The location provides convenient regional connectivity with immediate access to Highway 101, proximity to Highway 280 and Highway 380, and access to Caltrain, ferry service, and San Francisco International Airport. Occupiers benefit from nearby restaurants, hotels, recreation amenities, and services throughout South San Francisco's Oyster Point and Lindenville districts. The property's combination of infrastructure, flexibility, transportation access, and positioning within a recognized life science market makes it well suited for organizations seeking a strategic Bay Area presence.

Property Facts

Building Size
44,311 SF
Lot Size
1.65 AC
Year Built
2001
Construction
Steel
Power Supply
Amps: 900-3,000 Volts: 277-480 Phase: 3
Zoning
BTP-M - Business Technology Park - Medium
Fairly walkable
50/100
Exceptionally drivable
100/100
Some public transit
40/100
Moderately bikeable
70/100
  • Listing ID: 41480012

  • Date on Market: 2026-07-29

  • Last Updated:

  • Address: 468 Littlefield Ave, South San Francisco, CA 94080

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