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Highlights

  • Prime Alfred Precinct location, providing unrivaled adjacency to leading medical and research organizations, including Alfred Health.
  • Floorplates ranging from 735 m² to over 1,500 m², all offering excellent natural light and side-core efficiency.
  • Direct pedestrian access to Alfred Hospital, ensuring safe and seamless connectivity for tenants and visitors.
  • Abundant secure on-site parking available for staff and visitors.

All Available Spaces(5)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • Ground
  • 7,922 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now

The ground floor at 553 St Kilda Road offers 735.8 m² of prime office/showroom space with immediate street presence and direct access to the Alfred Medical Precinct from the rear entry. This versatile level can accommodate a mix of reception, client-facing areas, open-plan zones, or specialized consulting/health uses. Large glazing lines deliver strong natural light alongside excellent exposure to St Kilda Road’s active commercial corridor.

  • Fits 20 - 62 People
  • Direct pedestrian link to Alfred Hospital
  • Secure on-site parking available
  • 735.8 m² with highly visible street frontage
  • Efficient open-plan layout
  • 1st Floor
  • 11,743 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now

Level 1 provides a highly adaptable 1,090.7 m² floorplate, combining open-plan workspace capacity with enclosed meeting and executive zones. Its side-core design ensures excellent spatial efficiency and fitout options for collaborative workplaces or medical/research administration settings.

  • Fits 30 - 91 People
  • Expansive 1,090.7 m² tenancy
  • 2nd Floor
  • 16,587 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now

This generous floorplate is perfect for major corporate users or clinical research specialists requiring large-scale occupancy. Its 1,540.9 m² layout features clear spans and abundant light, facilitating open-plan work areas, laboratories, or hybrid design concepts.

  • Fits 42 - 129 People
  • 1,540.9 m² office tenancy
  • 3rd Floor
  • 16,587 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now

This generous floorplate is perfect for major corporate users or clinical research specialists requiring large-scale occupancy. Its 1,540.9 m² layout features clear spans and abundant light, facilitating open-plan work areas, laboratories, or hybrid design concepts.

  • Fits 42 - 129 People
  • 1,540.9 m² office tenancy
  • 4th Floor
  • 16,490 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request
  • Office
  • -
  • Now

Level 4 provides 1,532 m² of exceptional office accommodation harnessing commanding views and a bright, elevated outlook. Designed for occupiers seeking a full-floor headquarters or flagship location, this tenancy accommodates sophisticated layouts while maintaining efficient open-plan capability.

  • Fits 42 - 128 People
  • 1,532 m² office tenancy
Space Size Term Rental Rate Space Use Build-Out Available
Ground 7,922 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
1st Floor 11,743 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
2nd Floor 16,587 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
3rd Floor 16,587 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now
4th Floor 16,490 SF Negotiable Upon Request Upon Request Upon Request Upon Request Office - Now

Ground

Size
7,922 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
Now

1st Floor

Size
11,743 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
Now

2nd Floor

Size
16,587 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
Now

3rd Floor

Size
16,587 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
Now

4th Floor

Size
16,490 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request
Space Use
Office
Build-Out
-
Available
Now

Ground

Size 7,922 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available Now

The ground floor at 553 St Kilda Road offers 735.8 m² of prime office/showroom space with immediate street presence and direct access to the Alfred Medical Precinct from the rear entry. This versatile level can accommodate a mix of reception, client-facing areas, open-plan zones, or specialized consulting/health uses. Large glazing lines deliver strong natural light alongside excellent exposure to St Kilda Road’s active commercial corridor.

  • Fits 20 - 62 People
  • 735.8 m² with highly visible street frontage
  • Direct pedestrian link to Alfred Hospital
  • Efficient open-plan layout
  • Secure on-site parking available

1st Floor

Size 11,743 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available Now

Level 1 provides a highly adaptable 1,090.7 m² floorplate, combining open-plan workspace capacity with enclosed meeting and executive zones. Its side-core design ensures excellent spatial efficiency and fitout options for collaborative workplaces or medical/research administration settings.

  • Fits 30 - 91 People
  • Expansive 1,090.7 m² tenancy

2nd Floor

Size 16,587 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available Now

This generous floorplate is perfect for major corporate users or clinical research specialists requiring large-scale occupancy. Its 1,540.9 m² layout features clear spans and abundant light, facilitating open-plan work areas, laboratories, or hybrid design concepts.

  • Fits 42 - 129 People
  • 1,540.9 m² office tenancy

3rd Floor

Size 16,587 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available Now

This generous floorplate is perfect for major corporate users or clinical research specialists requiring large-scale occupancy. Its 1,540.9 m² layout features clear spans and abundant light, facilitating open-plan work areas, laboratories, or hybrid design concepts.

  • Fits 42 - 129 People
  • 1,540.9 m² office tenancy

4th Floor

Size 16,490 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office
Build-Out -
Available Now

Level 4 provides 1,532 m² of exceptional office accommodation harnessing commanding views and a bright, elevated outlook. Designed for occupiers seeking a full-floor headquarters or flagship location, this tenancy accommodates sophisticated layouts while maintaining efficient open-plan capability.

  • Fits 42 - 128 People
  • 1,532 m² office tenancy

Property Overview

Positioned in the heart of the prestigious Alfred Medical Precinct, 553 St Kilda Road presents a rare leasing opportunity offering 6,440 m² of premium office accommodation. Available for the first time in more than a decade, this landmark building provides occupiers with direct pedestrian access to the Alfred Hospital campus via a secure rear entry, supporting tenants in the health, research, or allied services sectors while appealing equally to corporate users seeking an elite address. The property features large side-core floorplates across five levels, delivering superior efficiency, high natural light penetration, and flexibility for open-plan or bespoke fitout configurations. Each floor benefits from excellent ceiling heights and professional-grade services, creating a significant advantage for businesses prioritizing workforce comfort and operational flow. The building also offers secure on-site parking, a 5-Star NABERS Energy rating, and proximity to the newly opened Anzac Train Station, providing outstanding connectivity.

  • Restaurant
  • Air Conditioning

Property Facts

Building Type
Office
Building Height
7 Stories
Building Size
113,021 SF
Building Class
B
Typical Floor Size
16,146 SF
Parking
183 Covered Parking Spaces
  • Listing ID: 40327258

  • Date on Market: 2026-04-29

  • Last Updated:

  • Address: 553 St Kilda Rd, Melbourne, VIC 3004

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