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601-621 Portola Dr 840 - 3,840 SF of Space Available in San Francisco, CA 94127
Highlights
- Heavy Traffic Corner in Twin Peaks-Established Dental office of 27 years.
All Available Spaces(2)
Display Rental Rate as
- Space
- Size
- Term
- Rental Rate
- Space Use
- Build-Out
- Available
- Lease rate does not include utilities, property expenses or building services
- 2 Private Offices
- 11 Workstations
- Space is in Excellent Condition
- Fits 8 - 24 People
- 2 Conference Rooms
- Finished Ceilings: 12’
- Twin Peaks
Excellent Corner Location – 621 Portola Drive In retail, location determines momentum—and 621 Portola Drive delivers a powerful one. Positioned prominently at the corner of Portola Drive and Teresita Boulevard in San Francisco’s desirable Twin Peaks neighborhood, this highly visible storefront benefits from steady neighborhood traffic, strong street presence, and built-in community engagement. The intersection placement provides exceptional signage exposure and natural walk-by activity—critical advantages for neighborhood-serving businesses. Zoned NC-1 (Neighborhood Commercial – Cluster One), the property supports a range of community-focused uses, including cafés, boutiques, specialty retail, personal services, wellness concepts, and professional offices. This zoning encourages businesses that become part of the neighborhood fabric—establishments that generate repeat clientele and long-term loyalty. A Built-In Customer Base Twin Peaks is known for its tree-lined streets, established residential density, and strong sense of community. The surrounding homes create a consistent local customer base within walking distance—an invaluable driver for retail success. The property is also strategically located near West Portal and Glen Park, expanding the trade area and increasing daily consumer flow. Easy access to MUNI lines and major thoroughfares ensures convenience for both neighborhood residents and visitors. Directly adjacent is Mollie Stone’s Markets, a well-established specialty grocer that anchors the corridor and drives consistent foot traffic. Nearby dining destinations such as Fresca and Mozzarella di Bufala further enhance the vibrancy of the immediate area, creating a synergistic retail environment. Property Highlights 840 sq. ft. vacant corner unit High-visibility frontage at a signalized intersection NC-1 zoning supporting neighborhood-serving retail and service uses Flexible open layout — ideal blank canvas for customization Private restroom Strong pedestrian and vehicle exposure Adjacent to an established grocery anchor Located within a stable, high-demand residential community Why This Location Works Corner positioning enhances brand recognition. Consistent daily neighborhood traffic Established residential density supports repeat customers Proximity to multiple vibrant commercial districts Transit accessibility expands customer reach 621 Portola Drive offers more than space—it offers positioning. For businesses seeking strong community integration, consistent visibility, and long-term stability, this location provides a strategic foundation for success. Contact us today to explore how your business can thrive at this exceptional Twin Peaks address.
- Listed rate may not include certain utilities, building services and property expenses
- Mostly Open Floor Plan Layout
- Corner Space
- Fully Built-Out as Standard Retail Space
- Fits 3 - 7 People
- Twin Peaks-Great Visibility-High Traffic Corner
| Space | Size | Term | Rental Rate | Space Use | Build-Out | Available |
| Ground, Ste 601 | 3,000 SF | Negotiable | $47.11 CAD/SF/YR $3.93 CAD/SF/MO $141,331 CAD/YR $11,778 CAD/MO | Office/Medical | - | Now |
| 1st Floor, Ste 621 | 840 SF | Negotiable | $98.70 CAD/SF/YR $8.22 CAD/SF/MO $82,908 CAD/YR $6,909 CAD/MO | Office/Retail | Full Build-Out | Now |
Ground, Ste 601
| Size |
| 3,000 SF |
| Term |
| Negotiable |
| Rental Rate |
| $47.11 CAD/SF/YR $3.93 CAD/SF/MO $141,331 CAD/YR $11,778 CAD/MO |
| Space Use |
| Office/Medical |
| Build-Out |
| - |
| Available |
| Now |
1st Floor, Ste 621
| Size |
| 840 SF |
| Term |
| Negotiable |
| Rental Rate |
| $98.70 CAD/SF/YR $8.22 CAD/SF/MO $82,908 CAD/YR $6,909 CAD/MO |
| Space Use |
| Office/Retail |
| Build-Out |
| Full Build-Out |
| Available |
| Now |
Ground, Ste 601
| Size | 3,000 SF |
| Term | Negotiable |
| Rental Rate | $47.11 CAD/SF/YR |
| Space Use | Office/Medical |
| Build-Out | - |
| Available | Now |
- Lease rate does not include utilities, property expenses or building services
- Fits 8 - 24 People
- 2 Private Offices
- 2 Conference Rooms
- 11 Workstations
- Finished Ceilings: 12’
- Space is in Excellent Condition
- Twin Peaks
1st Floor, Ste 621
| Size | 840 SF |
| Term | Negotiable |
| Rental Rate | $98.70 CAD/SF/YR |
| Space Use | Office/Retail |
| Build-Out | Full Build-Out |
| Available | Now |
Excellent Corner Location – 621 Portola Drive In retail, location determines momentum—and 621 Portola Drive delivers a powerful one. Positioned prominently at the corner of Portola Drive and Teresita Boulevard in San Francisco’s desirable Twin Peaks neighborhood, this highly visible storefront benefits from steady neighborhood traffic, strong street presence, and built-in community engagement. The intersection placement provides exceptional signage exposure and natural walk-by activity—critical advantages for neighborhood-serving businesses. Zoned NC-1 (Neighborhood Commercial – Cluster One), the property supports a range of community-focused uses, including cafés, boutiques, specialty retail, personal services, wellness concepts, and professional offices. This zoning encourages businesses that become part of the neighborhood fabric—establishments that generate repeat clientele and long-term loyalty. A Built-In Customer Base Twin Peaks is known for its tree-lined streets, established residential density, and strong sense of community. The surrounding homes create a consistent local customer base within walking distance—an invaluable driver for retail success. The property is also strategically located near West Portal and Glen Park, expanding the trade area and increasing daily consumer flow. Easy access to MUNI lines and major thoroughfares ensures convenience for both neighborhood residents and visitors. Directly adjacent is Mollie Stone’s Markets, a well-established specialty grocer that anchors the corridor and drives consistent foot traffic. Nearby dining destinations such as Fresca and Mozzarella di Bufala further enhance the vibrancy of the immediate area, creating a synergistic retail environment. Property Highlights 840 sq. ft. vacant corner unit High-visibility frontage at a signalized intersection NC-1 zoning supporting neighborhood-serving retail and service uses Flexible open layout — ideal blank canvas for customization Private restroom Strong pedestrian and vehicle exposure Adjacent to an established grocery anchor Located within a stable, high-demand residential community Why This Location Works Corner positioning enhances brand recognition. Consistent daily neighborhood traffic Established residential density supports repeat customers Proximity to multiple vibrant commercial districts Transit accessibility expands customer reach 621 Portola Drive offers more than space—it offers positioning. For businesses seeking strong community integration, consistent visibility, and long-term stability, this location provides a strategic foundation for success. Contact us today to explore how your business can thrive at this exceptional Twin Peaks address.
- Listed rate may not include certain utilities, building services and property expenses
- Fully Built-Out as Standard Retail Space
- Mostly Open Floor Plan Layout
- Fits 3 - 7 People
- Corner Space
- Twin Peaks-Great Visibility-High Traffic Corner
Property Overview
Prime Professional Medical/Wellness Office Space for Lease!! Position your business for long-term success in this fully built-out, highly visible professional space located in a prime, high-traffic corridor. Formerly home to a thriving dental practice for over 27 years, this well-designed and versatile property offers an exceptional opportunity for dental, medical, wellness, or select retail users seeking a turnkey or easily adaptable environment. Whether you are launching, expanding, or relocating, this space provides the infrastructure, visibility, and flexibility to support your growth—without the time and expense of building from the ground up. Property Features: Generous Layout: Approximately 3,000 sq. ft. of thoughtfully designed, functional space suitable for clinical, professional, or boutique commercial use. Built-Out Clinical Infrastructure Eight fully equipped operatories with plumbing, cabinetry, and fixtures already in place—ideal for dental use and readily adaptable for medical, wellness, or treatment-based services. Welcoming Reception Area: Spacious and comfortable waiting environment designed to enhance client and patient experience. Private Offices & Staff Areas: Dedicated administrative and provider offices, plus staff workspace and full kitchen/breakroom to support daily operations efficiently. Specialized Equipment & Treatment Areas: Includes digital X-ray system, sterilization room, and darkroom—convertible for medical imaging, lab, or procedural use depending on tenant needs. Restrooms: Modern, clean, and well-maintained facilities for patients, clients, and staff. Ample On-Site Parking: Convenient parking for both staff and visitors—an essential feature for healthcare and customer-facing businesses. Move-In Ready: Existing improvements allow for immediate occupancy, with flexibility for customization. Location Advantages: High-Visibility Setting: Prominent location with strong vehicle and foot traffic, providing excellent exposure for healthcare or retail-oriented businesses. Excellent Accessibility: Conveniently located near major transportation routes, residential neighborhoods, and established commercial services. Strong Community Demographics: Situated in a well-established area with consistent demand for healthcare, wellness, and neighborhood-serving retail services. Lease Highlights: Flexible Lease Terms Structured to accommodate a range of professional, medical, or retail users. Tenant Improvement Opportunities: Ability to customize layout and finishes to suit dental, medical, wellness, or boutique retail concepts. Immediate Occupancy Available: Minimal downtime—ideal for businesses seeking a seamless transition. Ideal Uses: This versatile space is well-suited for: Dental Practice (General or Specialty) Medical or Healthcare Office Wellness / Aesthetic / MedSpa Physical Therapy or Rehabilitation Specialty Medical Services Professional Office Use Boutique Health-Focused or Service Retail (subject to approval) Building Highlights Prime high-visibility location with strong exposure Former long-standing dental practice (27+ years) Turnkey clinical infrastructure with existing plumbing and wiring Flexible layout adaptable for medical, dental, wellness, or retail use Professional reception, private offices, and staff facilities On-site parking for convenience and accessibility Close proximity to major transportation corridors Zoning supports medical, professional, and related commercial uses Located in an established, high-demand service area Opportunity: This is a rare opportunity to secure a well-located, fully improved professional space with exceptional flexibility. Whether continuing as a dental office or transforming into a medical, wellness, or specialty retail destination, the foundation is already in place for long-term success. Contact us today to schedule a private tour and explore how this space can support your next phase of growth.
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Property Facts
Select Tenants
- Floor
- Tenant Name
- Industry
- 1st
- Caken' Cuts Barbershop
- Services
- 1st
- Portola Nail Spa
- Services
- 1st
- Pro Dental Care
- Health Care and Social Assistance
- 1st
- Tower Cleaners
- Services
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601-621 Portola Dr
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