15 Convenience Stores for Lease in Charleston, SC, USA

Mount Pleasant Office/Medical for Lease - East Islands/Mt Pleasant

Mount Pleasant Medical Office Longpoint is a professionally managed healthcare facility offering a modern and efficient environment for today’s medical providers. Located at 570 Long Point Road near Interstate 526, the two-story building provides strong visibility and convenient access in one of the Charleston area’s fastest-growing communities. The property is designed to accommodate a wide range of practices. Flexible floor plans, private exterior suite entrances, and a clean, contemporary layout make it well-suited for specialties such as primary care, outpatient procedures, wellness services, and specialty clinics. A total of 155 surface parking spaces and nearby bus routes ensure smooth access for patients and staff. Tenants benefit from competitive lease packages and generous tenant improvement allowances, creating opportunities for custom build-outs or turnkey solutions. Current occupants include a dermatology practice, a family medicine clinic, and a functional medicine provider, offering natural referral opportunities and a collaborative medical environment. The building is Energy Star certified, delivering cost efficiency and sustainable operations. Surrounded by retail, dining, pharmacies, and banking, the property combines patient convenience with professional exposure. Mount Pleasant Medical Office Longpoint establishes itself as an exceptional place of care, providing healthcare professionals with a setting that supports both.

Property Type:

Office

Date on Market:

2025-08-21

North Charleston Retail, Flex for Lease - Dorchester County

Total Project Size: 30,043 SF 1,900 - 20,341 SF available for lease Suites 101 - 106: 11,986 SF (Fully Built Out) Suite 107: LEASED Suite 108: LEASED Suite 109: 1,951 SF (Warm Vanilla Shell; Roll-Up Door) Suite 110: 1,951 SF (Warm Vanilla Shell) Suite 111: 2,302 SF (Cold Dark Shell; Roll-Up Door) Suite 112: 2,151 SF (Cold Dark Shell) 158 parking spaces 40’ Future Common Dock Area Centrally located in North Charleston, SC with 52,100 VPD

Date on Market:

2025-11-25

Charleston Retail for Lease - Downtown Charleston

Property Type:

Office

Date on Market:

2025-12-30

Charleston Office/Retail for Lease - Downtown Charleston

Positioned on a prominent corner lot in the heart of Charleston’s rapidly emerging NoMo District, 716 Meeting Street offers a rare opportunity for businesses seeking a distinctive, high-visibility office environment. This two-story boutique office building combines character and convenience, making it ideal for creative firms, technology companies, and high-end service providers that value image, accessibility, and exposure. Its corner positioning provides excellent signage opportunities and continuous visibility along one of downtown Charleston’s most active corridors. Inside, tenants will appreciate the efficient floorplans, abundant natural light, and a professional yet creative atmosphere that enhances both client impressions and employee experience. The building’s scale makes it perfectly suited for companies seeking a stand-alone identity rather than a shared multi-tenant complex. Located among some of Charleston’s most exciting new developments, restaurants, and innovative businesses, 716 Meeting Street offers the energy of a growing district with the convenience of downtown access.

Property Type:

Retail

Date on Market:

2025-11-03

Charleston Office for Lease - Downtown Charleston

Property Type:

Flex

Date on Market:

2025-10-03

Mount Pleasant Office for Lease - East Islands/Mt Pleasant

Elevate your business in this prominent Class A office suite located in a tranquil Mount Pleasant setting. Offering direct access from the parking lot, this exceptional first-floor space boasts an efficient floor plan designed for productivity. The layout includes a welcoming reception area, conference room, seven private offices, and a dedicated copy station. Enjoy the convenience of a highly accessible location just minutes from I-526. The main lobby areas recently underwent a full renovation. This is a sublease available through September 30, 2027, with the option for a longer-term lease directly with the landlord.

Date on Market:

2025-08-06

Mount Pleasant Office for Lease - East Islands/Mt Pleasant

The property at 537 Long Point Road in Mount Pleasant, SC, is an office building located near the intersection of Long Point Road and I-526. The site is positioned within a developed commercial corridor with nearby retail, dining, and service establishments. The building is undergoing renovations that include exterior and interior improvements. The location provides access to major transportation routes and is in proximity to the Charleston metropolitan area.

Date on Market:

2026-03-16

Charleston Office for Lease - James Island/Folly Beach

NAI Charleston is pleased to present 125C Wappoo Creek Drive, for lease. This ±660-2,200 SF office space is located on the second floor above Charleston Oral & Facial Surgery in the coveted Wappoo Creek area of James Island. This located provides for outstanding convenience to population centers of James Island, Johns Island, West Ashley, and downtown Charleston. The versatile floor plan is well-suited for a variety of professional office uses. Outstanding convenience to James Island, Johns Island, West Ashley, and downtown Charleston. Functional floor plan with private offices, open work areas, a full kitchen, and a restroom with shower can accommodate a variety of professional uses. Clean and ready for immediate occupancy! Full Floor: ±2,200 Rentable SF, Suite A: ±1,540 Rentable SF, Suite B: ±660 Rentable SF

Date on Market:

2025-04-02

Charleston Retail for Lease - Downtown Charleston

Date on Market:

2025-03-06

Charleston Office for Lease - West Ashley

This office condo is located within the Town Center Office Park and could serve a variety of medical or general office uses. It is approximately 3,290 square feet consisting of 6 exam rooms, 4 private offices, reception area, 2 restrooms, a conference room and a large procedure/conference room. Other existing users located within this business park include a law practice, land development firm, a counseling center and a professional office. The property is located just off of Savannah Highway, and is less than a half a mile from Interstate 526. Current NNN's are estimated to be $7.22/psf. The Town Center Office Park is a modern, suburban development designed to accommodate a mix of professional services and medical office users. It consists of two low-rise buildings, each featuring contemporary architecture with clean lines, ample windows for natural light, and inviting entryways. The buildings feature well-maintained landscaping, including manicured lawns and decorative trees, creating a professional yet welcoming atmosphere. Parking is convenient and abundant. The office park is strategically located near key suburban amenities, including: Restaurants and Cafes, Casual dining spots, Retail Centers, coffee shops, Health and Fitness Facilities all within a short driving distance.

Date on Market:

2024-11-26

North Charleston Office for Lease

Discover an exceptional opportunity at 5617 North Rhett Avenue, Charleston, SC, where modern office space is available for lease starting March 1, 2025. This 1,755 square foot office suite is situated in a multi-tenant building, offering an optimal location that provides easy access to Charleston's vibrant business community. The space is designed for efficiency and comfort, making it ideal for your professional needs. Tenants will enjoy a full-service lease, which includes all essential utilities and services. Additionally, a shared conference room is available on a first-come, first-served basis, perfect for meetings and collaborative work. Don’t miss your chance to establish your business in this sought-after location—contact us today for more information!

Property Type:

Flex

Date on Market:

2025-03-17

Mount Pleasant Office, Office/Medical for Lease - East Islands/Mt Pleasant

This is an attractive single-story brick office building within a 4-building complex known as the Wando Commons. Quick access to Interstate 526 and immediate access to Mount Pleasant and greater Charleston. Plenty of nearby restaurants, Starbucks, and shopping. On-site parking is provided. Tenants are responsible for utilities and janitorial services. Taxes, Insurance, and Common area maintenance fees are $5.94 psf.

Date on Market:

2026-02-19

Charleston Office for Lease - Downtown Charleston

Charleston Gateway Campus offers a unique walkable complex of buildings occupied by professional office and service related businesses. 480 East Bay tenants include a restaurant Marbled & Fin, Charleston Prestige Cleaners, and The Charleston Symphony. Numerous other daytime and evening amenities are a short walking distance from the campus. This preeminent site provides the opportunity to establish a presence in one of the city’s most visible properties conveniently located at the intersection of Calhoun and East Bay streets within close proximity to the base of the Ravenel Bridges and I-26. The class A office building is offered on full service basis and the tenant mix is primarily legal, insurance and financial services companies. Some parking is available for lease both on-site and in the Aquarium/Galliard garages. A back-up generator allows for uninterrupted service in the event of a power outage. Access to rooftop with harbor views is available after hours by reservation.

Date on Market:

2026-01-26

Charleston Coworking for Lease - Downtown Charleston

Historic 460 King Street used to be home to Robinson Toy Store for decades. Since then, the first floor has served well as space for different restaurants and nightlife venues over the years. Currently, 460 King Street is home to Office Evolution on the 2nd floor... the very same space that the Robinson family used to store bicycles! If you ask, we still have bike tags from almost 100 years ago!

Property Type:

Retail

Date on Market:

2017-05-22

Charleston Office for Lease - West Ashley

NAI Charleston is pleased to present 1525-1527-1529 Sam Rittenberg Blvd, an exclusive office leasing opportunity at The Ritt Business Park. This multi-tenant office park offers modern, well-appointed suites in a variety of sizes to accommodate a wide range of tenant needs. Thoughtfully renovated in 2025, this classic business park now features a distinctive, contemporary finish. Each suite reflects the developer’s discerning attention to detail, blending a timeless, distinguished aesthetic and cohesive branding into modern functionality throughout the campus. The Ritt offers a premium, fully equipped conference center—complete with a private reception area and modern kitchenette—that can be reserved by both in-house tenants and outside businesses seeking a professional, upscale meeting space. What truly sets The Ritt apart is the developer’s vision and commitment to quality and detail. Every aspect of the property has been carefully curated to create a tasteful, professional, and welcoming environment that leaves a lasting impression. Ideally located in close proximity to desirable retail and dining options, The Ritt Business Park offers both convenience and prestige in one exceptional setting,

Date on Market:

2026-03-03