South San Francisco Portfolio of properties for Sale
PREMIER PENINSULA LOCATION
The property occupies a prominent 4.54-acre position on El Camino Real — the Peninsula’s most recognized commercial corridor stretching from San Francisco to San Jose. Land assemblages of this scale are virtually nonexistent along the boulevard, where parcelization & long-standing ownership make large-format sites exceptionally rare. The City has designated this stretch of El Camino Real as a primary growth area for high-density mixed-use development under the Shape SSF 2040 General Plan.
PRO-HOUSING MUNICIPAL ENVIRONMENT
South San Francisco plans to nearly double its housing stock from 21,200 to 39,000 units by 2040, with a specific target of 5,000 new units along El Camino Real. The City’s Housing Element, certified by the State in 2023, identifies a RHNA allocation of 3,956 units by 2031. The City is actively investing in corridor improvements through the Grand Boulevard Initiative & El Camino Real Mobility Plan, enhancing streetscape, transit access, & pedestrian infrastructure along the boulevard.
UNENTITLED SITE — MAXIMUM FLEXIBILITY
Delivered without entitlements, the site provides a developer full creative control to design a project that maximizes value. The T5C Form-Based Code offers clear, predictable standards that streamline the entitlement process, while California’s Density Bonus Law provides significant additional upside — up to 50% above base density — for projects that include affordable housing components.
ADJACENT TO THE BIOTECH CAPITAL OF THE WORLD
South San Francisco hosts 250+ biotech companies across 12+ million SF of dedicated lab & office space. Genentech alone employs ±13,000 workers at its campus, which serves as U.S. headquarters for Roche. Other major employers include Amgen, AbbVie, Calico Life Sciences (Alphabet), Exelixis ($2.3B revenue), & Veracyte. Average biotech salaries exceed $150,000, creating an unmatched pool of high-income renters who drive premium housing demand.
EXCEPTIONAL TRANSIT CONNECTIVITY
The site benefits from proximity to South San Francisco BART (~20 min to downtown SF), San Bruno Caltrain (full Peninsula corridor to San Jose), & SamTrans bus routes directly on El Camino Real. Highway 101 (~20-30 miles south to Silicon Valley), I-280, & the immediately adjacent I-380 interchange provide seamless regional access. San Francisco International Airport is approximately 2 miles away. This transit-rich profile supports reduced parking ratios under the Form-Based Code, directly improving project economics.
FASTEST RENT GROWTH IN THE NATION
As of Q4 2025, SF metro multifamily vacancy has fallen to 4.6% — the lowest since 2014 — while annual rent growth of 5.7–5.9% leads all major U.S. metros. Only ~2,800 units are under construction metro-wide, representing just 1.5% of inventory. San Mateo County average rents are approximately $3,600/month & rising nearly 5% annually. This severe supply-demand imbalance creates a powerful backdrop for new development.
SUPPLY-CONSTRAINED INFILL MARKET
Developable land on the Peninsula is extraordinarily limited. Built-out conditions, lengthy entitlement timelines, & construction cost escalation make new development increasingly challenging. Sites of 4+ acres with by-right high density zoning along El Camino Real are virtually nonexistent, giving this property a significant scarcity premium in a market where demand for new housing far outpaces supply.
AFFLUENT, HIGHLY EDUCATED DEMOGRAPHICS
Within a 3-mile radius: 139,000+ population, average household income of $185,898, & median home values exceeding $1.3 million. The workforce is 66% white collar with 46% of adults holding a bachelor’s degree or higher & unemployment at just 3.4%. Annual consumer spending exceeds $2.1 billion within 3 miles.
EXCELLENT CORRIDOR VISIBILITY
The property commands significant frontage along El Camino Real with average daily traffic exceeding 45,000 vehicles. The adjacent I-380 carries over 143,000 cars per day. This visibility enhances project branding, ground-floor retail activation, & leasing velocity from day one.
