133 Storefront Properties for Lease in San Francisco, CA, USA

San Francisco Office/Retail for Lease - West of Van Ness

At the corner of Union and Buchanan, find 2001 Union Street, a trophy office building in San Francisco, California. This marvelous property spans over 84,236 square feet with six stories of office, retail, medical, and underground parking. The building was renovated in 2017, and each unit has refined modern features, including glassed rooms, updated flooring, exposed ceilings, and floor-to-ceiling windows with views of the Bay. Amenities at 2001 Union Street include an on-site property manager, underground fee parking, bike storage, air conditioning, and ground-floor storefront retail and dining. 2001 Union Street offers exceptional accessibility to the Golden Gate Bridge and the San Francisco Bay via Highway 101. Getting around town from the office without a car is easy as several bus lines stop nearby. This landmark building is in the heart of one of San Francisco's most well-known neighborhoods, Cow Hollow. Cow Hollow is a desirable area that showcases Victorian and Edwardian-style homes, world-class boutique shopping, and ample entertainment opportunities. This upscale residential neighborhood draws in a diverse mix of young professionals and delivers the perfect walkable urban location with something to do on every corner.

Property Type:

Office

Date on Market:

2026-05-22

San Francisco Office/Retail for Lease - West of Van Ness

4200 17th Street presents a rare opportunity to establish a business in one of San Francisco's most vibrant and high-traffic commercial corridors. This well-configured commercial space offers flexibility for a wide range of retail, professional service, or office uses, with ground-floor visibility and upper-level private workspace, all within walking distance of the Castro's core amenities and transit connections.

Property Type:

Retail

Date on Market:

2026-06-25

San Francisco Retail for Lease - Union Square

Date on Market:

2026-06-25

San Francisco Office for Lease - Mission/Potrero

Spacious and Clean 2Br/2Ba Unit on the second Floor, Elevator, Patio, located in the heart of the Vibrant Mission District

Property Type:

Retail

Date on Market:

2026-06-08

San Francisco Retail for Lease - Southern City

FOR LEASE | 3417 Mission Street, San Francisco, CA Prime Mission District Retail / Showroom / Creative Commercial Space Approx. 1,190 Sq. Ft. Position your business in the heart of San Francisco's vibrant Mission District. This highly visible street-front commercial space offers an open and flexible floor plan ideal for retail, gallery, showroom, creative office, wellness, beauty, design studio, specialty services, and a variety of other commercial uses. Recently refreshed with modern finishes, the space features soaring ceilings, expansive storefront windows, abundant natural light, and excellent street presence along one of San Francisco's most active commercial corridors. Property Highlights Approximately 1,190 square feet Large open retail/showroom area Private office or storage room Private restroom High ceilings with exposed beams Abundant natural light Attractive polished flooring Excellent storefront visibility Strong pedestrian and vehicle traffic Flexible layout suitable for numerous business types Prominent Mission Street location Surrounded by restaurants, cafés, retailers, and neighborhood services Easy access to public transportation and major commuter routes Location Situated on bustling Mission Street between Bernal Heights and the Excelsior District, this location benefits from consistent neighborhood traffic and excellent accessibility. The surrounding area is home to a diverse mix of established local businesses, national retailers, dining destinations, and residential neighborhoods, creating a strong customer base for a variety of commercial uses. Ideal Uses Boutique Retail Specialty Retail Showroom Art Gallery Design Studio Creative Office Wellness Studio Beauty Services Professional Services Specialty Food (subject to approvals)

Date on Market:

2026-06-04

San Francisco Office/Retail, Retail for Lease - Southern City

Date on Market:

2026-05-14

San Francisco Office for Lease - Southern City

Property Type:

Retail

Date on Market:

2026-05-11

San Francisco Industrial for Lease - Van Ness/Chinatown

Located in the heart of Nob Hill along a major corridor leading to Downtown San Francisco, 865 Post Street offers approximately 5,800 square feet of highly adaptable commercial space with an integrated residential/live-work component. This unique property is ideally suited for a wide range of users including creative office, showroom, boutique production, light industrial, or live-work operators seeking a central San Francisco location. The flexible layout allows for efficient operations while benefiting from a vibrant, amenity-rich urban setting. Positioned just minutes from Union Square and the Financial District, the property offers excellent accessibility, strong surrounding demographics, and immediate proximity to public transportation, dining, retail, and major employment centers.

Property Type:

Retail

Date on Market:

2026-05-04

San Francisco Office for Lease - Mission/Potrero

Large, Glass Storefront Facade Great Visibility and Signage Opportunity Ideally Located on 14th Off Bustling Guerrero St Accessible via Public Transportation, Direct Freeway Access Four (4) Large Private Offices Kitchenette New Paint and Electrical Shared Backyard Garden with a Seating Area

Property Type:

Retail

Date on Market:

2026-04-30

San Francisco Retail for Lease - Waterfront/North Beach

Located in the North Beach neighborhood of San Francisco, the subject space is situated in a high density location.

Date on Market:

2026-04-24

San Francisco Retail for Lease - Southern City

Date on Market:

2026-04-15

San Francisco Retail for Lease - Mission/Potrero

Discover the vibrant energy of one of San Francisco's most sought-after neighborhoods around the property. Located in the trendy Mission District, this bustling area is home to a diverse mix of boutique shops, gourmet restaurants, SF General Hospital, and trendy cafes. The property benefits from prime foot traffic, thanks to its proximity to popular landmarks like Dolores Park, SF Public Library, City College of SF, Mission Cultural Center, and more. Public transportation (Muni, BART, buses) and US-101 and I-280 freeways nearby. With its unique blend of art, culture, and culinary delights, the area offers an exciting opportunity for a Retail/Street Retail tenant to immerse themselves in the dynamic fabric of San Francisco's eclectic community. This building features a warehouse and retail storefront on the ground level, with a 1 bedroom/1 bath unit conveniently built above the retail space. This versatile property offers a range of possibilities for investors, developers, and owner-users seeking a mixed-use investment opportunity in a prime San Francisco location. Available for in-person tour: Mon-Fri 8AM-3PM. Contact Broker to schedule.

Date on Market:

2026-04-14

San Francisco Office for Lease - South of Market

Rare SoMa Loft | 3rd Floor | 4,000 SF | Creative/Office/Flex An exceptional opportunity to lease a full 4,000 SF loft on the third floor of a character-rich SoMa building at 221 11th Street. This open-plan space delivers the quintessential San Francisco creative loft experience — soaring ceilings, raw architectural detail, and flexible layout potential suited for tech, creative, media, wellness, or professional office uses. Highlights: 4,000 SF of contiguous loft space Third floor with natural light exposure Open floor plan — adaptable to a wide range of uses Located in the heart of SoMa, steps from the Central Freeway, BART, and Caltrain corridors Surrounded by SF's most dynamic mix of tech companies, studios, and hospitality Lease Terms: $36.00/SF/Year NNN $12,000/Month Available immediately — contact listing agent for tour scheduling SoMa remains one of the most sought-after submarkets in San Francisco for companies seeking authentic loft character with urban accessibility. This space is move-in ready and priced competitively for the market.

Property Type:

Retail

Date on Market:

2026-04-06

San Francisco Office for Lease - Financial District

686 Sacramento presents a rare leasing opportunity in the heart of San Francisco’s historic Financial District. This well maintained second-floor office suite offers approximately 2,200 square feet of thoughtfully designed workspace that blends character with modern functionality. The space features soaring ceilings, expansive windows, and abundant natural light throughout, creating an open and energizing work environment. The layout includes a large collaborative open area, four private offices or conference rooms, a fully equipped kitchen and pantry, and two restrooms — one of which includes a shower for added convenience. Ideal for offices seeking a distinctive, move-in-ready space in a premier downtown location, 686 Sacramento delivers both presence and practicality in one exceptional offering. $7,500 Per Month + NNN • Approximately 2,200 Sq. Ft. • Large Open Concept. • 4 Private Offices. • 2 Restrooms (Including 1 Shower). • Pride of Ownership – Well Maintained Including Hardwood Floors, Air Conditioning, and High Ceilings. • Lots of Natural Light. • Ideally Located in SF’s Bustling Financial District. San Francisco’s Financial District is the city’s premier business address—where global commerce meets iconic architecture and a dynamic urban lifestyle. Anchored by landmarks such as the Transamerica Pyramid and Embarcadero Center, the district’s skyline is instantly recognizable and synonymous with innovation, influence, and opportunity. Home to major financial institutions, Fortune 500 companies, venture capital firms, and leading law practices, the Financial District offers unparalleled access to decision-makers and industry leaders. Its prime location provides immediate connectivity to BART, Muni, ferries, and regional highways—making it one of the most accessible commercial hubs in the Bay Area. The neighborhood also delivers an exceptional work-life environment. From Michelin-starred dining and upscale cafés to luxury hotels and waterfront views along the Embarcadero, the Financial District blends professional prestige with vibrant city energy. For companies seeking visibility, credibility, and connectivity, San Francisco’s Financial District remains the gold standard in Northern CA.

Property Type:

Retail

Date on Market:

2020-07-09

San Francisco Retail for Lease - West of Van Ness

Rare Clement Street Office Opportunity | 5 Private Offices • Private Balcony • Natural Light Bright and well-appointed second-floor office suite offering five private offices and a flexible layout ideal for professional or creative businesses. The space features large windows throughout, allowing for abundant natural light that creates a comfortable and productive work environment. A notable advantage of the space is that the windows are operable, allowing for fresh air and natural ventilation—an uncommon feature in many modern office buildings. The suite includes central heating, two bathrooms, an intercom entry system for convenient guest access, and access to a rare private balcony—an ideal outdoor space for staff breaks, informal meetings, or simply enjoying fresh air during the workday. The efficient floor plan allows for a variety of configurations including private offices, meeting rooms, or collaborative workspace. Located along the vibrant Clement Street corridor in San Francisco's Richmond District, the property is surrounded by a dynamic mix of restaurants, cafes, and neighborhood retail. The location offers convenient access to public transportation and major city routes, including bus lines 44, 38, and 1, and provides quick access toward the Golden Gate Bridge. A unique advantage of this section of Clement Street is parking availability. The block typically offers more metered parking availability than many other parts of the Clement Street corridor, with street parking directly in front of the building and additional non-metered neighborhood parking located nearby around the corner, providing added convenience for employees and visiting clients. Ideal for a range of professional uses including medical or wellness practitioners, therapy or counseling practices, law offices, design studios, consulting firms, or small creative teams seeking a bright and well-located workspace in one of San Francisco's most established neighborhood business districts. The space is offered on a gross lease structure, providing tenants with simple and predictable monthly occupancy costs. 3D tour https://view.ricoh360.com/98e26a26-e20a-4bf6-9180-911d7fead006?type=compact Key Features *5 private offices *Central heating *2 bathrooms *Intercom entry system *Flexible layout for offices, meetings, or team space

Date on Market:

2026-03-18

San Francisco Office, Retail for Lease - Union Square

The property at 253 Grant Avenue is situated in San Francisco’s Union Square retail district, positioned between Union Square and the Chinatown Gate. The surrounding area includes hotels, offices, and retail establishments, attracting tourists and local shoppers. The site is accessible by public transit and is located in a dense urban environment with nearby lodging and commercial activity.

Date on Market:

2026-06-10

San Francisco Retail for Lease - Southern City

Date on Market:

2026-03-06

San Francisco Retail for Lease - Southern City

Date on Market:

2026-03-06

San Francisco Retail for Lease - Waterfront/North Beach

Ground Matrix, as Exclusive Advisor, is pleased to present a ±1,000 SF corner retail opportunity at 800 Bay Street, located at the intersection of Hyde and Bay within San Francisco’s Russian Hill / Fisherman’s Wharf corridor. Positioned along the Hyde Street cable car line and directly across from Francisco Park, the property benefits from exceptional corner visibility, steady pedestrian activity, and immediate access to the city’s most visited waterfront destinations. With an efficient layout and flexible use potential, 800 Bay Street offers retailers a highly recognizable San Francisco address in a highly sought after area.

Date on Market:

2026-03-02

San Francisco Retail for Lease - South of Market

Located at Boardman Place and Bryant Street in San Francisco's South of Market (SoMa) district, this mixed-use property, features ground-floor commercial space with residential units above. The available ±400 SF suite offers direct street-front access and flexible Service/Arts/Light Industrial (SAL) zoning, supporting a variety of retail, service, creative, and light commercial uses (tenant to verify). The surrounding area includes a strong mix of residential density, neighborhood businesses, and commercial activity, with convenient access to Highways 80 & 280, MUNI, BART, and Caltrain. Street parking is available along Bryant Street and surrounding blocks, with nearby public parking lots for additional convenience. Ideal opportunity for retail, professional services, or creative users seeking a centrally located SoMa address.

Date on Market:

2026-02-26

San Francisco Office/Medical, Office/Retail for Lease - Southern City

Prime Professional Medical/Wellness Office Space for Lease!! Position your business for long-term success in this fully built-out, highly visible professional space located in a prime, high-traffic corridor. Formerly home to a thriving dental practice for over 27 years, this well-designed and versatile property offers an exceptional opportunity for dental, medical, wellness, or select retail users seeking a turnkey or easily adaptable environment. Whether you are launching, expanding, or relocating, this space provides the infrastructure, visibility, and flexibility to support your growth—without the time and expense of building from the ground up. Property Features: Generous Layout: Approximately 3,000 sq. ft. of thoughtfully designed, functional space suitable for clinical, professional, or boutique commercial use. Built-Out Clinical Infrastructure Eight fully equipped operatories with plumbing, cabinetry, and fixtures already in place—ideal for dental use and readily adaptable for medical, wellness, or treatment-based services. Welcoming Reception Area: Spacious and comfortable waiting environment designed to enhance client and patient experience. Private Offices & Staff Areas: Dedicated administrative and provider offices, plus staff workspace and full kitchen/breakroom to support daily operations efficiently. Specialized Equipment & Treatment Areas: Includes digital X-ray system, sterilization room, and darkroom—convertible for medical imaging, lab, or procedural use depending on tenant needs. Restrooms: Modern, clean, and well-maintained facilities for patients, clients, and staff. Ample On-Site Parking: Convenient parking for both staff and visitors—an essential feature for healthcare and customer-facing businesses. Move-In Ready: Existing improvements allow for immediate occupancy, with flexibility for customization. Location Advantages: High-Visibility Setting: Prominent location with strong vehicle and foot traffic, providing excellent exposure for healthcare or retail-oriented businesses. Excellent Accessibility: Conveniently located near major transportation routes, residential neighborhoods, and established commercial services. Strong Community Demographics: Situated in a well-established area with consistent demand for healthcare, wellness, and neighborhood-serving retail services. Lease Highlights: Flexible Lease Terms Structured to accommodate a range of professional, medical, or retail users. Tenant Improvement Opportunities: Ability to customize layout and finishes to suit dental, medical, wellness, or boutique retail concepts. Immediate Occupancy Available: Minimal downtime—ideal for businesses seeking a seamless transition. Ideal Uses: This versatile space is well-suited for: Dental Practice (General or Specialty) Medical or Healthcare Office Wellness / Aesthetic / MedSpa Physical Therapy or Rehabilitation Specialty Medical Services Professional Office Use Boutique Health-Focused or Service Retail (subject to approval) Building Highlights Prime high-visibility location with strong exposure Former long-standing dental practice (27+ years) Turnkey clinical infrastructure with existing plumbing and wiring Flexible layout adaptable for medical, dental, wellness, or retail use Professional reception, private offices, and staff facilities On-site parking for convenience and accessibility Close proximity to major transportation corridors Zoning supports medical, professional, and related commercial uses Located in an established, high-demand service area Opportunity: This is a rare opportunity to secure a well-located, fully improved professional space with exceptional flexibility. Whether continuing as a dental office or transforming into a medical, wellness, or specialty retail destination, the foundation is already in place for long-term success. Contact us today to schedule a private tour and explore how this space can support your next phase of growth.

Date on Market:

2026-02-23

San Francisco Retail for Lease - Southern City

Ideally situated near San Bruno Avenue’s restaurants and retail amenities, with convenient access to public transportation and Highway 101. Open floor plan with a large garage in the rear of the building. Formally an Art Studio. Square footage is an approximation including the garage space. Lease Rate: $5,000/Month plus NNN

Date on Market:

2026-03-04

San Francisco Retail for Lease - West of Van Ness

Prime Union Street Retail Opportunity Rare chance to secure a highly desirable retail space in the heart of Cow Hollow. • Approx. 1,125 sq. ft. • Large storefront with two expansive window displays — true brand-defining frontage, nearly impossible to find in Cow Hollow • Excellent visibility and foot traffic • Flexible Lease Option: 2-5 years • Rent starting at $6,750/month + NNN Do not disturb tenant. Call Vic at 323-422-9093

Date on Market:

2026-01-28

San Francisco Retail for Lease - West of Van Ness

Located in the heart of the Central Richmond District in San Francisco

Date on Market:

2026-01-28