4201 N Main St - Lutheran Theological Southern Seminary 130,000 SF Specialty Building Offered at $24,170,999 CAD in Columbia, SC 29203

CBRE presents a rare opportunity to acquire a legacy campus in Columbia’s vibrant North Main Street (NOMA) district. Formerly home to the Lutheran Theological Southern Seminary and most recently operated by Lenoir-Rhyne University, this ±17.65-acre property offers a rich blend of historic architecture and modern educational infrastructure. The campus includes ±130,000 square feet of core facilities, five single-family residences, and two multifamily buildings, all situated in a walkable, amenity-rich corridor just minutes from downtown Columbia.
Anchored by Beam Hall, constructed in 1911, the campus features a chapel, auditorium, library, student union, and a recently built Occupational Therapy Education Facility. On-campus housing accommodates over 116 residents, with additional multifamily units offering 51 apartments across Smith Family Village and Hillcrest Village. The property’s layout supports a wide range of adaptive reuse possibilities, from educational and healthcare to residential or mixed-use redevelopment.
Columbia’s central location between major Southeastern cities, including Charlotte, Charleston, and Atlanta, enhances its appeal. The city boasts a population of over 861,000 in the MSA, a robust labor force, and proximity to major employers such as Prisma Health, BlueCross BlueShield, and the University of South Carolina. With affordable housing, strong educational infrastructure, and a thriving cultural scene, Columbia offers a compelling environment for institutional investment or redevelopment.