85 Life Science Properties for Lease in San Diego, CA, USA

San Diego Office for Lease - UTC

Discover what your teams could achieve in the heart of San Diego tech culture at Eastgate, the workplace for inventive minds. This 26-building campus redefines what's possible in La Jolla UTC, reimagining the workday with customizable spaces, sought-after amenities and unmatched location convenience. Recruit, retain and engage top talent with fitness, conferencing, sports courts and abundant outdoor enclaves for working and socializing in the open air. From move-in ready suites to full floors to full buildings, bring your company culture to life with personalized workspace, including the opportunity to develop a private, branded campus experience. Give your teams the convenience of 200+ elevated dining, shopping, wellness and entertainment options at Westfield UTC plus nearby beaches, luxury apartments, transportation and Torrey Pines Golf Course. Base your company in a fast-growing hub of life sciences and tech innovation among industry giants and access the local talent pipeline from UC San Diego and Scripps Research Institute. Lease with confidence from Irvine Company, San Diego’s locally trusted expert with 40+ years of homegrown expertise and exceptional customer care.

Date on Market:

2025-04-21

San Diego Flex for Lease - Scripps Ranch

Now available for lease, 10225 Willow Creek is a 75,119-square-foot multi-use building in Scripps Ranch. Ownership recently completed $4.75 million in building and site improvements, including a rooftop deck, hardscape and landscape, signage, and entrance facade improvements. 10225 Willow Creek has a slew of building specs to help with more efficient manufacturing productions. A new 4,000-amp electrical service was installed with all new transformers (480/277 volts) and switchgear. Plus, the site is permitted and ready for up to a 2-megawatt generator, pending tenant requirements. Along with the upcoming renovations, this project will be prepared to support mechanical units for lab and manufacturing use. The facility's clear height varies from 12- to 15-foot clearance, and may be able to accommodate some full building height (28-foot) uses. There are six dock-high positions served by two drive-in doors. Other site features include ample parking with 133 surface spots and 22 carport stalls, plus a hydraulic elevator installed in 2014. Located in the thriving Scripps Ranch submarket and surrounded by top talent, 10225 Willow Creek is neighbored by an array of corporate neighbors, including June Shine, Lockheed Martin, Iron Mountain, InnoTech Manufacturing, Apria, TechFlow, and Werfen. Drive times are desirable, as this modern building is just 14 minutes to Rancho Bernardo, 16 minutes to UTC (University Town Center), 20 minutes to Downtown and San Diego International Airport, and 25 minutes from Del Mar and La Jolla.

Date on Market:

2021-10-18

San Diego Flex for Lease - Sorrento Mesa

Capitalize on the opportunity to secure a move-in-ready suite comprising approximately 20,000 square feet of lab and office space, over 16 feet of clear height, one grade-level door, and a large parking lot. The divisible lab space features 110-foot-long chemical resistance lab benches, Clean/Dry Room and an additional newly installed 68-foot chemical resistance lab bench. Other property highlights include 480 volts, 1,000 amps of power, and bathroom janitor service. 10237 Flanders Court is a one-story, 39,388-square-foot flex property on a 2.57-acre lot. 10237 Flanders Court is in the heart of the Sorrento Valley, surrounded by an array of industrial companies, such as Scripps Laboratories, Geocon Incorporated, Qualcomm, Dexcom, Supply Pro, Inovio, Genalyte, and Apex Medical Technologies. Interstate 805 is reached within a five-minute drive of the property, which quickly connects to Interstate 5, providing connections throughout San Diego, Los Angeles, San Francisco, and Seattle. The San Diego International Airport is located 17 miles from the flex facility for delivering freight across the US and internationally. The advantageous University of California San Diego (UCSD) is only 5 miles away, where most students major in biology, computer science, anatomy, and global studies. Companies at the complex receive support from a well-trained and highly skilled labor force with over 55,914 residents living within a 10-mile radius employed in the warehousing sector.

Date on Market:

2024-09-13

San Diego Flex for Lease - Kearny Mesa

Exceptional opportunity to lease a highly improved freestanding building of 56,159 square feet in the most strategic location in all of San Diego, located in the heart of Kearny Mesa. Providing exceptional freeway and surface street access, this facility logistically from a business and quality of life perspective, is a home run. 4650 Overland Avenue is perfect for any flex, R&D, life science, lab, medical, and precision manufacturing applications. The interior has a mix of lab space, clean rooms, conference, private offices, open-plan bullpen areas, kitchen/lunchroom/lounge section, patios, and skylights. The warehouse space has numerous dock loading doors, great clear height, locker rooms, and showers. With a very distinctive architecture, this property creates an exceptional client and employee experience and energy that is unique and in a class of its own. All of this is supported by a robust HVAC and distribution system, multiple floor drains, waterlines, fully sprinklered areas, a backup diesel generator, a significant gas and air network, and a 4,000-amp, 277/480-volt power capacity, which can be cost-effectively expanded due to prior infrastructure preparation. The entire property can easily be enclosed, and a conduit is in place to install security gates. 4650 Overland Avenue is situated within the Spectrum Center, a very walkable and upscale neighborhood with a significant array of amenities within minutes. Multiple throughfares are proximate to the facility, including Interstates 15, 8, and 805, as well as the 163 and 52 freeways, which route into San Diego within a five-minute drive and extend into the Inland Empire and Los Angeles in under two hours. For easy connections to international and domestic markets, the San Diego International Airport is only 9.2 miles away. Don't miss out on a one-of-a-kind facility that can serve any manufacturing or distribution business long into the future, offering critical in-place infrastructure and flexible interior configurations that allow a business to scale and grow with its evolving operational requirements. This opportunity is perfect for an owner/user who is looking to expand their operation into a showstopping space.

Date on Market:

2025-05-14

San Diego Flex for Lease - Sorrento Mesa

Property Type:

Office

Date on Market:

2025-12-15

San Diego Office, Office/Medical for Lease - Sorrento Mesa

Rare owner-user or investment opportunity — a free-standing building in Sorrento Mesa offering the flexibility to occupy all or a portion of the building Abundance of on-site parking and adjacent street parking Exceptional visibility and signage, expansive window line, and elevator-served Zoning allows for a mix of uses Ease of commute with central location, short distance to freeway, and nearby transit options Synergy with adjacent tenants - situated in San Diego’s technology, life science and pharmaceutical hub

Date on Market:

2025-12-03

La Jolla Office/Medical for Lease

-Lease Rate: $3.25/SF + NNN -Building Size: 3,219 SF -Full Dental Buildout -4-5 Reserved Parking Spaces -Opportunity to divide the property into two or three private suites On-Site Amenities: Three (3) Office Spaces, One (1) Waiting Room, Seven (7) Clinical Rooms, One (1) Lab Space & Three (3) Restrooms Additional: Break Room, Storage Space, Loading Doors/Ramps, Water Access in Each Room, HVAC, a Kitchenette & a Server/Data Room

Property Type:

Office

Date on Market:

2025-10-23

San Diego Flex for Lease - Mira Mesa/Miramar

Date on Market:

2025-09-23

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-08-01

San Diego Flex for Lease - Mira Mesa/Miramar

• 22,930 SF Freestanding Building within an Association • Suite 100: 14,369 SF Available for Immediate Occupancy • Suite 150: 8,561 SF Leased Through February 2030 • Interior Renovation Work Underway! • Sale Price: $9,750,000 ($425.21/SF) • Association Fees: $19,500 annually ($0.07/SF monthly) • Lease Rate: $2.25/SF NNN • Operating Expenses: $0.58/SF • Parking: 7.8/1,000 (113 Stalls – 4.9/1,000 Non-Reserved, Onsite | 66 Stalls – 2.9/1,000 Non-Reserved, Common Area) • Electrical Service: Building Total: 1,000 Amp 277/480 Volt 3 Phase • Fire Sprinklered • Suite 100 Features: 2/3 Modern Office; 1/3 Production/Lab/Warehouse – Skylights in Production Area – Two Glass Panel Roll-Up Doors – 14’ Clear Height – Outstanding Window Line/Natural Light – Plumbing/Soil Lines in place for Wet Lab or other uses – Private Offices have Sidelight Windows – LED Lighting Throughout – Nicely Appointed Ground Floor Breakroom – Second Floor Coffee Bar • Parcel Size: 3.14 Acres; San Diego County • APN: 343-350-28-00 • Zoning: IL-2-1 • Highly Desirable Sorrento Mesa Submarket

Date on Market:

2025-07-17

San Diego Flex for Lease - Mira Mesa/Miramar

Property Type:

Industrial

Date on Market:

2025-06-10

San Diego Flex for Lease - Mira Mesa/Miramar

Date on Market:

2025-12-17

San Diego Flex for Lease - Mira Mesa/Miramar

This standalone 9,200 SF two-story flex/lab building offers a unique mix of lab, office, and warehouse space with building top signage available.

Date on Market:

2025-04-17

San Diego Flex for Lease - Mira Mesa/Miramar

Date on Market:

2025-04-07

San Diego Industrial for Lease - Mira Mesa/Miramar

• ± 51,296 SF Industrial Building • Private offices, open work space and assembly areas • 24’-30’ clear height warehouse • Dock high, grade level and step van loading • Large secure fenced yard • Concrete driveways and yard • Heavy power 4,000a/277-480v • High speed fiber to building • Ten-ton crane available • Natural Gas Service • Building can be 100% climate controlled • Building has 4,258 SF bonus storage mezzanine

Date on Market:

2025-03-18

San Diego Office for Lease - Sorrento Mesa

Former biotech facility, excellent parking, new landscaping, building signage opportunities.

Date on Market:

2025-02-20

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-02-12

San Diego Office for Lease - Mission Valley

Date on Market:

2025-11-06

La Mesa Office/Medical for Lease - East County

- 111 Onsite Parking Spaces - Medical office plaza with a diverse group of medical tenants - Located on the west side of La Mesa only minutes from Highway 8 and the village of La Mesa. - Multiple spaces built out for medical office use features water access and abundant treatment rooms. - TIs available for qualified tenants.

Property Type:

Office

Date on Market:

2025-03-06

San Diego Industrial for Lease - Sorrento Mesa

Sorrento Mesa Business Park is a 150,000 SF multi-tenant business park located just off Mira Mesa Blvd in the highly-desirable Sorrento Mesa submarket. Suites feature grade-level loading doors, warehouse skylights for natural lighting, on-site property management, easy access to freeways and an abundance of retail and restaurant amenities.

Date on Market:

2024-09-26

San Diego Office for Lease - Sorrento Mesa

Date on Market:

2025-11-19

San Diego Flex for Lease - Torrey Pines

Office and lab suites available with up to ~8,500 SF of contiguous space. Office suites range from ~100-300 SF each, while lab suites range from ~300-6,000 SF each.  Campus is abundant with amenities which include a conferencing center, cafeteria, gym, basketball court, tennis/pickleball courts, sand volleyball court, and lap pool. Secure campus perfect for incubator life science companies. • $100 broker touring bonus for qualified tours • Existing lab and office suites available for sublease • Campus setting with amenities • Abundant free parking available

Date on Market:

2025-04-09

San Diego Office for Lease - Sorrento Valley

Date on Market:

2024-06-05

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-06-16