Commercial Real Estate in San Francisco available for sale
San Francisco Life Science Properties For Sale

Life Science Properties for Sale in San Francisco, CA, USA

More details for 299 Rhine St, Daly City, CA - Multifamily for Sale

299 Rhine St

Daly City, CA 94014

  • Life Science
  • Multifamily for Sale
  • $1,948,380 CAD
  • 2,250 SF
  • 24 Hour Access

Daly City Multifamily for Sale - Brisbane/Daly City

299 Rhine Street in Daly City presents a well-maintained and thoughtfully upgraded triplex situated atop a hill with sweeping neighborhood and city views. Daly City is recognized as a stable and consistently strong rental market, benefiting from its proximity to San Francisco, and steady tenant demand driven by regional employment centers such as Oyster Point, a hub for world-renowned biotech companies. The property consists of three fully renovated one-bedroom units, offering an attractive and efficient unit mix for investors and tenants alike. The building includes one standard one-bedroom unit, one one-bedroom unit with a private garage, and one oversized one-bedroom unit featuring a substantial bonus room ideal for a home office, guest space, or additional living area. All three units have been tastefully updated, enhancing tenant appeal while minimizing near-term capital improvement needs. Residents benefit from an on-site laundry room and a private rear yard that can be shared among tenants—an increasingly desirable amenity that enhances livability and fosters a sense of community. The property’s elevated position not only provides excellent views but also creates a sense of privacy while remaining conveniently close to everyday essentials. The location offers immediate access to shopping, dining, and retail services at Serramonte Center, as well as convenient connectivity to major transportation corridors and nearby BART stations. 299 Rhine Street is within minutes of San Francisco State University, making it attractive to students and faculty, and just a short drive from the scenic Pacific coastline at Thornton State Beach, a popular local recreation destination. Commuters enjoy straightforward access to downtown San Francisco and the broader Peninsula employment centers. The property is also conveniently located near major freeways including Interstate 280 and U.S. Route 101, providing efficient regional connectivity throughout the Bay Area. Outdoor enthusiasts benefit from proximity to San Bruno Mountain State & County Park, which offers extensive hiking trails and panoramic Bay Area views. Combining renovated interiors, desirable amenities, and a prime hilltop setting near major conveniences and employment hubs, 299 Rhine Street represents a compelling multifamily investment opportunity in a strong and established rental market.

Contact:

Compass Commercial

Property Subtype:

Apartment

Date on Market:

2026-02-19
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More details for 2761-2765 16th St, San Francisco, CA - Retail for Sale

DAVITA ANCHORED VALUE-ADD OPPORTUNITY SF BAY - 2761-2765 16th St

San Francisco, CA 94103

  • Life Science
  • Retail for Sale
  • $15,169,530 CAD
  • 17,170 SF

San Francisco Retail for Sale - Mission/Potrero

Cushman & Wakefield is pleased to present a rare value-add investment opportunity at 2761–2765 16th Street, a 17,170± square-foot mixed-use property located in the heart of San Francisco’s vibrant A.I. and technology corridor. Originally built in 1929, the building underwent a comprehensive renovation in 2022, including a full seismic and structural retrofit, upgraded building systems (HVAC, 800-amp power, utilities, sprinklers), ADA-compliant restrooms and entrances, and a new roof. The property is divided into two condominiums and features a gated loading and delivery area with rear access via Enterprise Street. 2765 16th Street (12,046± sq. ft.) is fully leased to DaVita (NYSE: DVA) with +/-12-year remaining lease term with 10% rent increases every 5 years. 2761 16th Street (5,124± sq. ft.) offers a compelling value-add opportunity, with a planned vacancy in March 2026 and the potential to achieve a stabilized return on cost of 10.50%. 2761–2765 16th Street is a centrally located mixed-use property in San Francisco’s Mission District, positioned along the high-traffic 16th Street corridor (25,400+ vehicles daily) between Folsom and Harrison Streets. The area is a rapidly growing hub for Generative A.I., Life Sciences, and Technology, with neighbors such as Sequoia, OpenAI, Euclid AI, DoorDash, Comcast, Thinking Machines and Ouster, to name a few. The property offers exceptional accessibility with immediate proximity to the 16th & Mission BART station, multiple Muni routes, and easy freeway access. Surrounded by popular retail, dining, and entertainment options—plus national brands like Target, Costco, and Whole Foods—the site is minutes from the Financial District, SoMa, Hayes Valley, and Chase Center. Nearby medical centers, including UCSF Mission Bay, Zuckerberg SF General, and Sutter CPMC, support DaVita’s strong tenancy. The area features outstanding demographics, with average household income over $212,300 within one mile and a population exceeding 577,000 within three miles.

Contact:

Cushman & Wakefield

Property Subtype:

Storefront

Date on Market:

2025-09-10
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More details for 424 Brannan St, San Francisco, CA - Land for Sale

Irreplaceable Central SOMA Development - 424 Brannan St

San Francisco, CA 94107

  • Life Science
  • Land for Sale
  • Price Upon Request
  • 0.49 AC Lot

San Francisco Land for Sale - South of Market

424 Brannan (the “Project”), a +/- 21,400 square foot irreplaceable development opportunity located in San Francisco’s Central SOMA district. The Offering provides incredible optionality to leverage the Central SOMA Mixed-Use Office (CMUO) zoning which permits a wide variety of uses including residential, office, life sciences / lab, PDR, and hotel. Located on Brannan between 3rd and 4th Streets, the Project offers the development community an incredible ground-zero SOMA location within walking distance to the Central Subway rail line, the 4th & King Caltrain station, and the San Francisco Giant’s Oracle Park, as well as some of San Francisco’s most desirable urban amenities and attractions. 424 Brannan’s location is further enhanced by its immediate proximity to several prominent existing technology and VC users as well as several large-scale mixed-use office development projects which will continue to re-shape the immediate area.

Contact:

Colliers

Property Subtype:

Commercial

Date on Market:

2023-09-06
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Life Science Properties for Sale within 10 kilometers of San Francisco, CA, USA

More details for 141 S Maple Ave, South San Francisco, CA - Industrial for Sale
  • Matterport 3D Tour

141 S Maple Ave

South San Francisco, CA 94080

  • Life Science
  • Industrial for Sale
  • $17,396,250 CAD
  • 28,564 SF

South San Francisco Industrial for Sale

141 S Maple Avenue offers a versatile warehouse or yard space for sale, spanning two lots with a total area of 140,350 square feet. The first lot, APN: 014-092-180, covers 73,616 square feet, while the second lot, APN: 014-092-250, encompasses 66,734 square feet. The warehouse itself is 24,794 square feet, including a two-story office space of 3,815 square feet. The site offers 50,000 square feet of fenced-in yard space, making it ideal for construction storage, a bus yard, or redevelopment. Zoned T5L, for Lindenville mixed-use high-density, this site accommodates various commercial uses and valuable dense future residential development. South San Francisco is a prime industrial hub strategically located on the San Francisco Peninsula, offering immediate access to US Highway 101, Interstate 280, and San Francisco International Airport. Known for its strong logistics infrastructure and central Bay Area location, the city is ideal for warehousing, distribution, and light manufacturing. Businesses benefit from seamless regional connectivity and a well-established industrial market, supported by demand from biotech, transportation, and e-commerce sectors.

Contact:

Poletti Realty

Property Subtype:

Warehouse

Date on Market:

2025-10-29
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More details for 231 Lux Ave, South San Francisco, CA - Retail for Sale

Los Metates Taqueria - 231 Lux Ave

South San Francisco, CA 94080

  • Life Science
  • Retail for Sale
  • $1,530,870 CAD
  • 1,584 SF

South San Francisco Retail for Sale

Unlock the potential at 231 Lux Avenue, a rare mixed-use property in South San Francisco. This two-story building features a rented 3-bedroom, 1-bath residential unit and a long-standing commercial space with beer & wine license, offering a turnkey opportunity for income or owner-use. Imagine the endless possibilities: transform the space into a vibrant daycare, boutique retail, or modern professional office, split the lot to develop an additional parcel, or add an ADU for a separate multifamily unit. The property also accommodates outdoor seating, events, or specialized business uses, making it a flexible canvas for investors or entrepreneurs to maximize both income and lifestyle benefits. Broker's Tour: February 18, Wednesday from 1-2pm. With dual street access, a rear yard seating 40+ guests, and excellent exposure near Grand Avenue, Oyster Point, biotech campuses, and major freeways, this property offers unmatched convenience and visibility. Don’t miss this opportunity to own a South San Francisco property with income potential, live-work versatility, and endless development possibilities.

Contact:

Kinetic Real Estate

Property Subtype:

Storefront Retail/Residential

Date on Market:

2026-02-03
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More details for 435 Grand Ave, South San Francisco, CA - Office for Sale

435 Grand Ave

South San Francisco, CA 94080

  • Life Science
  • Office for Sale
  • $6,958,500 CAD
  • 7,995 SF
  • Air Conditioning
  • Security System
  • Reception
  • Wheelchair Accessible

South San Francisco Office for Sale

Prime Medical Office Opportunity Exceptional opportunity to acquire a well-located medical office building in the heart of South San Francisco’s established commercial corridor. Positioned on high-visibility Grand Avenue, this property benefits from strong pedestrian traffic, nearby retail amenities, and convenient access to Highway 101, I-280, BART, and SFO. The building offers a functional medical layout with reception area, private exam rooms, administrative offices, and support space. Ideal for owner-users seeking to control occupancy costs or investors looking to reposition or lease in a high-demand medical market. Surrounded by established businesses, residential neighborhoods, and biotech campuses, this location provides strong patient accessibility and long-term upside. A rare opportunity to secure medical office space in one of the Peninsula’s most supply-constrained submarkets.

Contact:

Christies International Real Estate

Property Subtype:

Medical

Date on Market:

2026-01-21
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More details for 514 Baden Ave, South San Francisco, CA - Multifamily for Sale

514 Baden Ave

South San Francisco, CA 94080

  • Life Science
  • Multifamily for Sale
  • $4,523,025 CAD
  • 12,825 SF

South San Francisco Multifamily for Sale

Over $219,000 in Gross Income per year... Wonderful opportunity to own 7 two bedroom units in the Downtown South San Francisco area. Each unit is 2 Bedrooms, 1 Bathroom with a GARAGE for parking. The downtown area is described as higher density living with shops, schools, parks, public transportation, restaurants and other desired services. There are also several major employment centers such as Genentech, Second Genome, Sutro Biopharma and Kaiser Permanente. South San Francisco is known as, "The Biotech Capital of the World." This could be the investment property you are looking for.

Contact:

Signature Realty DRE#01381122

Property Subtype:

Apartment

Date on Market:

2025-08-14
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More details for 20-24 Linden Ave, South San Francisco, CA - Office for Sale

20-24 Linden Ave

South San Francisco, CA 94080

  • Life Science
  • Office for Sale
  • $2,503,668 CAD
  • 2,760 SF

South San Francisco Office for Sale

Tenant has a Right of First Refusal to purchase. Please contact listing broker for more information. 20-24 Linden Ave offers a fantastic investment opportunity in thriving Downtown South San Francisco’s booming real estate market. The property offers ±2760 square feet of customizable space with 4 separate entrances, 4 separate electric meters, a large parking lot with and substantial ±7,650 lot parcel. High visibility corner location at Linden Avenue and Village Way. An impressive 92 WalkScore, walking distance to Grand Avenue and surrounding downtown area, walking distance to quaint boutiques, trendy cafes, and lively restaurants offering an a blend of culture, cuisine, and community, Downtown South SF has something for everyone. Convenient access to public transportation, both BART (Bay Area Rapid Transit) and Caltrain, ensuring that commuters and visitors can easily navigate the Bay Area and even the San Francisco International Airport (SFO), all within minutes of Downtown South SF. Located in the heart of the Bay Area, South San Francisco is in a strategic location and currently undergoing an exciting transformation with new opportunities. A recent development boom is reshaping the skyline and redefining urban living. Recent development of 1000+ residential units and another 800+ recently completed, under construction, or anticipated to be under construction soon and growing. Benefit from South San Francisco's strategic location and robust economy driven by biotech, technology, and healthcare industries. South San Francisco is the biotechnology capital of the world and home to one of the largest biotech clusters in the world. Over 250 biotech companies space form the anchor of South San Francisco's economy. It is home to world-renowned biotech companies and research institutions including Genentech, Amgen, 3T Bioscience, Vistagen, Calico Life Sciences, GRAIL, Sutro Biopharma and so many more. South San Francisco is being chosen by a growing number of businesses as their home, opportunities for career growth and networking are plentiful Zoning information: T3 Corridor Zoning District (T3C). The T3C zoning district is a low-and medium-intensity mixed-use district that supports community-serving uses adjacent to established residential neighborhoods. Located on corridors and nodes near existing residential areas, the district supports active, walkable streets and a range of neighborhood and community services. Buildings face the street and provide a transition in scale to surrounding lower-density areas. Diverse frontages engage private development with the public realm. All information deemed accurate but not guaranteed, subject to change at any time, Broker/Agent does not assume legal responsibility for omissions or errors.

Contact:

Quest Real Estate

Date on Market:

2024-07-06
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More details for 486 Cabot Rd, South San Francisco, CA - Flex for Sale

486 Cabot Rd

South San Francisco, CA 94080

  • Life Science
  • Flex for Sale
  • Price Upon Request
  • 16,008 SF
  • Bio-Tech/ Lab Space

South San Francisco Flex for Sale

Kidder Mathews is proud to be the exclusive marketing advisor for this single-tenant investment opportunity, strategically situated in California's biotech hub. 486 Cabot is a single-building property spanning 16,008 SF on 1-acre of land in South San Francisco, CA. The building is currently fully leased to Gordian Biotechnology through November 2027. This single-story property offers convenient access to Highways 101, 280, 80, and 380, with a Caltrain station just five blocks away, ensuring excellent connectivity.

Contact:

Kidder Mathews

Property Subtype:

Flex Research & Development

Date on Market:

2025-07-14
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United States Life Science Properties California San Francisco

Life Science Properties For Sale

Life Science Properties

Life Science Buildings for Sale or Lease

Life science properties are a type of commercial property that is commonly used by biotech companies to house lab equipment and research. They are also seen in medical facilities, universities, and manufacturing. There are different types of life science buildings for sale or lease available so you can decide if this would be a good investment for your business.

Life Science Buildings For Sale Or Lease: What Are The Different Types?

Life science buildings are a major investment for any company, and they can be categorized into three different categories: office space, laboratory space, or manufacturing spaces.

  • Office spaces offer the most flexibility to companies who work on many different types of tasks because it has more room for expansion in the future.
  • Lab facilities provide hands-on experience with equipment that is often difficult to get outside of an academic setting, including clean rooms.
  • Manufacturing spaces hold machinery such as autoclaves, centrifuges and other lab equipment required for scientific research and drug or medical manufacturing.

Looking to lease a Life Science? View Life Science Properties for lease