15 Life Science Properties for Lease in South Carolina, USA

Mount Pleasant Office/Medical for Lease - East Islands/Mt Pleasant

Mount Pleasant Medical Office Longpoint is a professionally managed healthcare facility offering a modern and efficient environment for today’s medical providers. Located at 570 Long Point Road near Interstate 526, the two-story building provides strong visibility and convenient access in one of the Charleston area’s fastest-growing communities. The property is designed to accommodate a wide range of practices. Flexible floor plans, private exterior suite entrances, and a clean, contemporary layout make it well-suited for specialties such as primary care, outpatient procedures, wellness services, and specialty clinics. A total of 155 surface parking spaces and nearby bus routes ensure smooth access for patients and staff. Tenants benefit from competitive lease packages and generous tenant improvement allowances, creating opportunities for custom build-outs or turnkey solutions. Current occupants include a dermatology practice, a family medicine clinic, and a functional medicine provider, offering natural referral opportunities and a collaborative medical environment. The building is Energy Star certified, delivering cost efficiency and sustainable operations. Surrounded by retail, dining, pharmacies, and banking, the property combines patient convenience with professional exposure. Mount Pleasant Medical Office Longpoint establishes itself as an exceptional place of care, providing healthcare professionals with a setting that supports both.

Property Type:

Office

Date on Market:

2025-08-21

Spartanburg Office, Flex for Lease - North Side/Rt 9 Corridor

Corporate Center, Spartanburg's premier business park, offers a notable opportunity for flex users seeking flexible office, manufacturing, and warehouse space. Currently comprising 400,000 square feet with plans to expand to 1.5 million square feet, Corporate Center ensures that tenants' immediate and long-term needs will be fulfilled. The available suites currently offer various amenities, including loading docks, drive-in doors, utilities available, 24-foot clear heights, ample surface parking, and fully built-out offices. Tenants are provided a unique experience with an on-site designer and architect ready to customize the space to fit their immediate and long-term occupancy and expansion needs. The property is near other major industrial users in upstate South Carolina, including Omnicare, Magna, and PECTEC, and is 20 miles from Greenville-Spartanburg International Airport. One-day truck service from Spartanburg County can reach 44% of the US population. Corporate Center is close to major thoroughfares, including Interstates 85 and 585.

Date on Market:

2026-02-27

Spartanburg Office for Lease - North Side/Rt 9 Corridor

Enter the innovation-driven economic landscape of Spartanburg, South Carolina, by leasing one of Corporate Center’s multifaceted spaces designed for office users, distributors, medical lab users, advanced manufacturing, R&D, and more. 111 Corporate Drive is a 48,300-square-foot industrial flex building located within Corporate Center, a premier business park in Spartanburg, South Carolina. Strategically positioned on 193 acres directly off Interstate 85, this Class A industrial property offers exceptional access to the Interstate 85 business corridor, connecting major Southeastern markets such as Charlotte, North Carolina, and Atlanta, Georgia. Corporate Center currently features 400,000 square feet of flexible office, warehouse, and manufacturing space, with plans to expand to 1.5 million square feet to accommodate immediate and long-term tenant growth. A 10,000-square-foot turnkey suite is currently available and has a full build-out ideal for office, lab, R&D, or light industrial use due to its high-spec infrastructure. It offers four external loading docks and two drive-in bays, wide column spacing, exterior walls with a high insulation rating, and high ceilings to create a mezzanine. The offices are fully furnished and ready for quick move-ins, plus an on-site generator ensures an uninterrupted power supply. Tenants benefit from being part of a synergistic business environment designed to support a wide range of commercial and industrial operations. The location offers significant logistical advantages, including proximity to the South Carolina Inland Port (SCIP), just 19 miles away, and Greenville-Spartanburg International Airport, located 21 miles from the site. SCIP alone handled nearly 2.8 million TEUs as of 2022, underscoring the region’s strength in freight and cargo movement. Corporate Center is also conveniently located near major employers such as Milliken (2.9 miles), Amazon Fulfillment (9.5 miles), and BMW Manufacturing (20 miles), making it an ideal location for companies seeking to integrate into a thriving industrial ecosystem. Spartanburg’s economy is powered by over 350 companies in the automotive, aerospace, biotech, energy, and advanced materials sectors, which together account for more than 30% of the local economic base. The area offers a robust and growing labor pool, with a population of 221,178 within a 10-mile radius and a projected annual growth rate of 2.7%, outpacing the national average. With its prime location, scalable infrastructure, and access to a skilled workforce, 111 Corporate Drive at Corporate Center presents a compelling opportunity for businesses seeking high-quality industrial space for lease in Spartanburg, South Carolina.

Property Type:

Flex

Date on Market:

2025-09-08

Beaufort Medical for Lease

This 60,440 square foot medical office building is located at 300 Midtown Drive in Beaufort, South Carolina. The property has a robust tenant roster including Select Physical Therapy Beaufort and Beaufort Memorial Lowcountry Medical Group Primary Care. The office is located 10 miles from Beaufort Memorial Hospital.

Property Type:

Office

Date on Market:

2023-04-10

Columbia Office for Lease - St Andrews

Professional second-floor office suite available for lease at 540 St. Andrews Road. The suite features two private offices and a dedicated lobby/reception area, ideal for a variety of professional uses including legal, consulting, therapy, real estate, financial services, or administrative operations. Suite Features: Two (2) private offices Reception/lobby area Second-floor location Professional setting Utilities & Amenities: Water included Shared restroom access Shared electricity Location Highlights: Conveniently located on St. Andrews Road with easy access to surrounding retail, dining, and major thoroughfares. Lease Information: Modified Gross (Water Included) Tenant responsible for agreed-upon shared utilities

Date on Market:

2026-03-02

Greenville Office/Retail for Lease - West Side Greenville

Crescent Startup Community, is a large-scale mixed-use Innovation District that provides a dedicated space for startups, entrepreneurs, and the development of innovative ideas and research. Join the largest and most diverse group of businesses and entrepreneurs in the Upstate!

Property Type:

Office

Date on Market:

2026-03-02

Greenville Office, Flex for Lease - Pelham Road

30 Pointe Circle offers a versatile floor plan with multiple offices, conference rooms and open meeting rooms. Ample parking available. The lower level includes four offices, restrooms, a separate entrance and two large garage bays with 18+ ceilings, partially conditioned.

Date on Market:

2026-01-29

Spartanburg Office/Medical for Lease - Spartanburg CBD

Excellent opportunity to lease a newly remodeled semi turn-key dental office ready for immediate use. The space currently includes two restorative operatories, with room to add an additional operatory, plus a large hygiene bay capable of accommodating up to eight dental chairs—ideal for a start up and future growth. A substantial amount of dental equipment is already on site and available to purchase or lease at a discounted rate, significantly reducing startup costs and allowing a new tenant to open quickly. Highlights Newly remodeled dental suite 2 existing restorative operatories Space to add additional operatory Hygiene bay with capacity for up to 8 chairs Dental equipment available at discounted purchase or lease terms Perfect for a startup dentist, expanding practice, or specialty provider seeking a fast and cost-effective launch.

Property Type:

Office

Date on Market:

2025-12-23

Charleston Flex for Lease - North Charleston

Date on Market:

2025-07-18

Columbia Office/Medical for Lease - Forest Acres

Three building ±126,002 RSF medical office building complex located in Columbia SC's Central Business District. Site is adjacent to the Providence/LifePoint Health campus. Customized suites are available and all three buildings have completed extensive common area renovations on all floors. Great location. Easily accessible with ample parking. Please contact listing brokers for further details or to schedule a site tour.

Property Type:

Office

Date on Market:

2025-12-05

Union Industrial for Lease - Union County

This premier industrial facility in Union, SC is now available for lease, offering exception flexibility for advanced manufacturing operations. The 122,256 square-foot building features high-clear ceilings (33'-36'6"), expansive production and warehouse areas, and Class A office accommodations. A 100,000 square-foot expansion pad provides scalability for future needs, while the building's modern design ensures operational efficiency. The property is fully climate-controlled with advanced HVAC systems, supported by redundant heavy power infrastructure and fiber optic connectivity. Dock-high loading doors, drive-in access, and a robust sprinkler system enhance functionality and safety. Formerly configured for biotech production, the facility includes mezzanine lab space and conference-ready offices, catering to diverse industrial requirements. Located just 18 miles from I-26 and 30 miles from I-85, tenants benefit from seamless regional access to Greenville, Charlotte, and Columbia, as well as proximity to the SC Inland Port and GSP International Airport. Union County offers a favorable business climate and workforce advantages, making this site an ideal choice for companies seeking a strategic Southeast location. With modern construction, expansion potential, and superior logistics connectivity, this property delivers unmatched value for forward-thinking operators.

Date on Market:

2026-01-21

Summerville Coworking for Lease - Outlying Berkeley County

Property Type:

Office

Date on Market:

2025-07-14

Rock Hill Office, Office/Medical for Lease - York County

Affluent Retail/Restaurant/Office Corridor In Rock Hill , SC (Charlotte MSA) with over 50,000 cars per day and just minutes to I-77. 14,837 rsf  first floor space available - with expansion up to 23,230 + rsf., located in highly sought after mixed-use market center First Floor can be demised into min 2500 sf suites Executive Suites Options starting at 150 sf 115 parking spaces with additional on street parking with room for expansion Potential owner-user opportunity for lease with option to purchase

Date on Market:

2025-07-24

North Charleston Office, Office/Medical for Lease - Dorchester County

Executive office suites for lease. Availabilities include: Suite 1: ±220 sf for $1,100/month Suite 11: ±187 sf for $750/month Suite 14: ±202 sf for $1,000/month

Date on Market:

2025-08-18

Columbia Office/Medical for Lease - Forest Acres

Located next to the MUSC Health Columbia Medical Center Campus at the corner of Two Notch Road and Laurel Street.

Property Type:

Office

Date on Market:

2023-05-08