133 Storefront Properties for Lease in San Francisco County, USA

San Francisco Office/Medical, Office/Retail for Lease - West of Van Ness

At the corner of Union and Buchanan, find 2001 Union Street, a trophy office building in San Francisco, California. This marvelous property spans over 84,236 square feet with six stories of office, retail, medical, and underground parking. The building was renovated in 2017, and each unit has refined modern features, including glassed rooms, updated flooring, exposed ceilings, and floor-to-ceiling windows with views of the Bay. Amenities at 2001 Union Street include an on-site property manager, underground fee parking, bike storage, air conditioning, and ground-floor storefront retail and dining. 2001 Union Street offers exceptional accessibility to the Golden Gate Bridge and the San Francisco Bay via Highway 101. Getting around town from the office without a car is easy as several bus lines stop nearby. This landmark building is in the heart of one of San Francisco's most well-known neighborhoods, Cow Hollow. Cow Hollow is a desirable area that showcases Victorian and Edwardian-style homes, world-class boutique shopping, and ample entertainment opportunities. This upscale residential neighborhood draws in a diverse mix of young professionals and delivers the perfect walkable urban location with something to do on every corner.

Date on Market:

2026-03-24

San Francisco Retail for Lease - Mission/Potrero

Discover the vibrant energy of one of San Francisco's most sought-after neighborhoods around the property. Located in the trendy Mission District, this bustling area is home to a diverse mix of boutique shops, gourmet restaurants, SF General Hospital, and trendy cafes. The property benefits from prime foot traffic, thanks to its proximity to popular landmarks like Dolores Park, SF Public Library, City College of SF, Mission Cultural Center, and more. Public transportation (Muni, BART, buses) and US-101 and I-280 freeways nearby. With its unique blend of art, culture, and culinary delights, the area offers an exciting opportunity for a Retail/Street Retail tenant to immerse themselves in the dynamic fabric of San Francisco's eclectic community. This building features a warehouse and retail storefront on the ground level, with a 1 bedroom/1 bath unit conveniently built above the retail space. This versatile property offers a range of possibilities for investors, developers, and owner-users seeking a mixed-use investment opportunity in a prime San Francisco location. Available for in-person tour: Mon-Fri 8AM-3PM. Contact Broker to schedule.

Date on Market:

2026-04-14

San Francisco Office for Lease - South of Market

Rare SoMa Loft | 3rd Floor | 4,000 SF | Creative/Office/Flex An exceptional opportunity to lease a full 4,000 SF loft on the third floor of a character-rich SoMa building at 221 11th Street. This open-plan space delivers the quintessential San Francisco creative loft experience — soaring ceilings, raw architectural detail, and flexible layout potential suited for tech, creative, media, wellness, or professional office uses. Highlights: 4,000 SF of contiguous loft space Third floor with natural light exposure Open floor plan — adaptable to a wide range of uses Located in the heart of SoMa, steps from the Central Freeway, BART, and Caltrain corridors Surrounded by SF's most dynamic mix of tech companies, studios, and hospitality Lease Terms: $36.00/SF/Year NNN $12,000/Month Available immediately — contact listing agent for tour scheduling SoMa remains one of the most sought-after submarkets in San Francisco for companies seeking authentic loft character with urban accessibility. This space is move-in ready and priced competitively for the market.

Property Type:

Retail

Date on Market:

2026-04-06

San Francisco Retail for Lease - West of Van Ness

The property includes one restroom and offers delivery improvements to accommodate tenant needs. Located in a high-density area, the site benefits from strong pedestrian traffic and excellent connectivity to key city destinations. Tenants will appreciate the proximity to Haight Street Muni, Alamo Square Park, and The Panhandle, as well as quick access to major neighborhoods such as Civic Center, Mission District, and Union Square. Convenient freeway access to US-101, I-280, and I-80 ensures ease of transportation for customers and employees alike.

Property Type:

Multifamily

Date on Market:

2026-03-28

San Francisco Retail for Lease - West of Van Ness

Rare Clement Street Office Opportunity | 5 Private Offices • Private Balcony • Natural Light Bright and well-appointed second-floor office suite offering five private offices and a flexible layout ideal for professional or creative businesses. The space features large windows throughout, allowing for abundant natural light that creates a comfortable and productive work environment. A notable advantage of the space is that the windows are operable, allowing for fresh air and natural ventilation—an uncommon feature in many modern office buildings. The suite includes central heating, two bathrooms, an intercom entry system for convenient guest access, and access to a rare private balcony—an ideal outdoor space for staff breaks, informal meetings, or simply enjoying fresh air during the workday. The efficient floor plan allows for a variety of configurations including private offices, meeting rooms, or collaborative workspace. Located along the vibrant Clement Street corridor in San Francisco's Richmond District, the property is surrounded by a dynamic mix of restaurants, cafes, and neighborhood retail. The location offers convenient access to public transportation and major city routes, including bus lines 44, 38, and 1, and provides quick access toward the Golden Gate Bridge. A unique advantage of this section of Clement Street is parking availability. The block typically offers more metered parking availability than many other parts of the Clement Street corridor, with street parking directly in front of the building and additional non-metered neighborhood parking located nearby around the corner, providing added convenience for employees and visiting clients. Ideal for a range of professional uses including medical or wellness practitioners, therapy or counseling practices, law offices, design studios, consulting firms, or small creative teams seeking a bright and well-located workspace in one of San Francisco's most established neighborhood business districts. The space is offered on a gross lease structure, providing tenants with simple and predictable monthly occupancy costs. 3D tour https://view.ricoh360.com/98e26a26-e20a-4bf6-9180-911d7fead006?type=compact Key Features *5 private offices *Central heating *2 bathrooms *Intercom entry system *Flexible layout for offices, meetings, or team space

Date on Market:

2026-03-18

San Francisco Retail for Lease - Waterfront/North Beach

Property Type:

Multifamily

Date on Market:

2026-03-18

San Francisco Office for Lease - Mission/Potrero

Approximately 3,000 SF available on 2nd Floor. Open space features three private offices, kitchen/break area and two bathrooms. Previously occupied by a church, the space can be used for light industrial or office use. Landlord looking for a creative tenant. Landlord will work with tenant to make the space fit to tenant needs. Download OM/flyer. Make offer!

Property Type:

Retail

Date on Market:

2026-03-17

San Francisco Office, Retail for Lease - Union Square

The property at 253 Grant Avenue is situated in San Francisco’s Union Square retail district, positioned between Union Square and the Chinatown Gate. The surrounding area includes hotels, offices, and retail establishments, attracting tourists and local shoppers. The site is accessible by public transit and is located in a dense urban environment with nearby lodging and commercial activity.

Date on Market:

2026-03-19

San Francisco Retail for Lease - Southern City

Date on Market:

2026-03-06

San Francisco Office/Retail for Lease - Bayview/Hunters Point

Multi-use property with office/retail space on the first floor and a separate residential unit on the 2nd floor

Property Type:

Retail

Date on Market:

2026-03-02

San Francisco Retail for Lease - Waterfront/North Beach

Ground Matrix, as Exclusive Advisor, is pleased to present a ±1,000 SF corner retail opportunity at 800 Bay Street, located at the intersection of Hyde and Bay within San Francisco’s Russian Hill / Fisherman’s Wharf corridor. Positioned along the Hyde Street cable car line and directly across from Francisco Park, the property benefits from exceptional corner visibility, steady pedestrian activity, and immediate access to the city’s most visited waterfront destinations. With an efficient layout and flexible use potential, 800 Bay Street offers retailers a highly recognizable San Francisco address in a highly sought after area.

Date on Market:

2026-03-02

San Francisco Retail for Lease - South of Market

Located at Boardman Place and Bryant Street in San Francisco's South of Market (SoMa) district, this mixed-use property, features ground-floor commercial space with residential units above. The available ±400 SF suite offers direct street-front access and flexible Service/Arts/Light Industrial (SAL) zoning, supporting a variety of retail, service, creative, and light commercial uses (tenant to verify). The surrounding area includes a strong mix of residential density, neighborhood businesses, and commercial activity, with convenient access to Highways 80 & 280, MUNI, BART, and Caltrain. Street parking is available along Bryant Street and surrounding blocks, with nearby public parking lots for additional convenience. Ideal opportunity for retail, professional services, or creative users seeking a centrally located SoMa address.

Date on Market:

2026-02-26

San Francisco Office/Medical, Office/Retail for Lease - Southern City

Prime Professional Medical/Wellness Office Space for Lease!! Position your business for long-term success in this fully built-out, highly visible professional space located in a prime, high-traffic corridor. Formerly home to a thriving dental practice for over 27 years, this well-designed and versatile property offers an exceptional opportunity for dental, medical, wellness, or select retail users seeking a turnkey or easily adaptable environment. Whether you are launching, expanding, or relocating, this space provides the infrastructure, visibility, and flexibility to support your growth—without the time and expense of building from the ground up. Property Features: Generous Layout: Approximately 3,000 sq. ft. of thoughtfully designed, functional space suitable for clinical, professional, or boutique commercial use. Built-Out Clinical Infrastructure Eight fully equipped operatories with plumbing, cabinetry, and fixtures already in place—ideal for dental use and readily adaptable for medical, wellness, or treatment-based services. Welcoming Reception Area: Spacious and comfortable waiting environment designed to enhance client and patient experience. Private Offices & Staff Areas: Dedicated administrative and provider offices, plus staff workspace and full kitchen/breakroom to support daily operations efficiently. Specialized Equipment & Treatment Areas: Includes digital X-ray system, sterilization room, and darkroom—convertible for medical imaging, lab, or procedural use depending on tenant needs. Restrooms: Modern, clean, and well-maintained facilities for patients, clients, and staff. Ample On-Site Parking: Convenient parking for both staff and visitors—an essential feature for healthcare and customer-facing businesses. Move-In Ready: Existing improvements allow for immediate occupancy, with flexibility for customization. Location Advantages: High-Visibility Setting: Prominent location with strong vehicle and foot traffic, providing excellent exposure for healthcare or retail-oriented businesses. Excellent Accessibility: Conveniently located near major transportation routes, residential neighborhoods, and established commercial services. Strong Community Demographics: Situated in a well-established area with consistent demand for healthcare, wellness, and neighborhood-serving retail services. Lease Highlights: Flexible Lease Terms Structured to accommodate a range of professional, medical, or retail users. Tenant Improvement Opportunities: Ability to customize layout and finishes to suit dental, medical, wellness, or boutique retail concepts. Immediate Occupancy Available: Minimal downtime—ideal for businesses seeking a seamless transition. Ideal Uses: This versatile space is well-suited for: Dental Practice (General or Specialty) Medical or Healthcare Office Wellness / Aesthetic / MedSpa Physical Therapy or Rehabilitation Specialty Medical Services Professional Office Use Boutique Health-Focused or Service Retail (subject to approval) Building Highlights Prime high-visibility location with strong exposure Former long-standing dental practice (27+ years) Turnkey clinical infrastructure with existing plumbing and wiring Flexible layout adaptable for medical, dental, wellness, or retail use Professional reception, private offices, and staff facilities On-site parking for convenience and accessibility Close proximity to major transportation corridors Zoning supports medical, professional, and related commercial uses Located in an established, high-demand service area Opportunity: This is a rare opportunity to secure a well-located, fully improved professional space with exceptional flexibility. Whether continuing as a dental office or transforming into a medical, wellness, or specialty retail destination, the foundation is already in place for long-term success. Contact us today to schedule a private tour and explore how this space can support your next phase of growth.

Date on Market:

2026-02-23

San Francisco Office for Lease - Yerba Buena

Prime second-floor suite located along the Folsom corridor near 4th & 5th Street. Features a spacious layout with two large open work areas, abundant natural light, private showers, an open kitchen with large countertops, phone rooms, and ample storage — fully furnished and move-in ready.

Property Type:

Retail

Date on Market:

2026-02-18

San Francisco Retail for Lease - Van Ness/Chinatown

Introducing 2020 Polk Street – The Final Retail Space at Maison Pacific in Russian Hill Positioned at the heart of Russian Hill’s bustling retail corridor, offering a rare and refined shopping experience. At the intersection of Pacific and Polk Street, your business will enjoy an eye-catching Polk Street storefront that draws customers in with its charm. High ceilings set a dramatic tone upon entry, creating an unforgettable first impression. A brand-new construction retail space that is fully built out, you have a completely blank canvas to define. You can design the space to fit your brand's aesthetic and create a unique shopping experience for your customers. The robust 200-amp electric service caters to your power needs seamlessly. Envision your brand amidst a league of sophisticated co-tenants surrounded by elegance and style. Neighbors. Saint Frank Coffee, Nisei, No. 3 Fine Jewelry, SSAL, Blue Barn, Fiorella, Philz Coffee, Bi-Rite Market, Molte Cose, Russian Hill Bookstore, Niche & Nook, Lord Stanley, Gary Hutton Design, Jug Shop, Cheese Plus, Café Reveille

Property Type:

Multifamily

Date on Market:

2026-02-11

San Francisco Office/Retail for Lease - Southern City

Property Type:

Multifamily

Date on Market:

2026-02-09

San Francisco Retail for Lease - Southern City

Date on Market:

2026-01-29

San Francisco Retail for Lease - West of Van Ness

Prime Union Street Retail Opportunity Rare chance to secure a highly desirable retail space in the heart of Cow Hollow. • Approx. 1,100 sq. ft. • Large storefront with two expansive window displays — true brand-defining frontage, nearly impossible to find in Cow Hollow • Excellent visibility and foot traffic • 18-month Sublease opportunity • First 6 months: $8,000/month • Following 12 months: $8,500/month • All taxes and NNN charges included • Longer lease possible. Do not disturb tenant. Call Vic at 323-422-9093

Date on Market:

2026-01-28

San Francisco Retail for Lease - West of Van Ness

Located in the heart of the Central Richmond District in San Francisco

Date on Market:

2026-01-28

San Francisco Office for Lease - Union Square

Date on Market:

2026-01-08

San Francisco Retail for Lease - Van Ness/Chinatown

Desirable Lower Nob Hill location, walkable to nearby amenities and to surrounding neighborhoods.

Property Type:

Multifamily

Date on Market:

2025-12-18

San Francisco Office, Retail for Lease - West of Van Ness

High identity mixed-use 3 story commercial building with easy access and onsite parking in the rear. Steps from Fillmore Street. Amenity rich location.

Date on Market:

2025-11-26

San Francisco Office/Retail for Lease - Southern City

Discover a premier leasing opportunity located at 2143-2145 Taraval St, San Francisco, CA, 94112. This exceptional property offers modern amenities and versatile spaces designed to elevate your business operations. Boasting expansive, light-filled interiors and sophisticated architecture, the property provides a premier environment for productivity and collaboration. With flexible floor plans, state-of-the-art technology infrastructure, and professional concierge services, this space is perfectly suited to meet the evolving needs of your business. Whether you're seeking a flagship office space or a dynamic business headquarters, this property provides the ideal foundation for success in the vibrant San Francisco market.

Property Type:

Retail

Date on Market:

2025-11-11

San Francisco Retail for Lease - Mission/Potrero

3618 17th Street is a Highly visible Retail Storefront in the Prime Mission Dolores District near Dolores Park. The property has good foot traffic and neighborhood exposure. The spacious interior features high ceilings, abundant natural light throughout large display windows, track lighting, newer flooring, and a convenient pantry or storage area. Open floor plan allows for flexible retail or service-oriented uses.

Date on Market:

2025-11-07