44 Life Science Properties for Lease in Boston, MA, USA

Somerville Office for Lease - Somerville/Everett

74M is a breakthrough life science development in Somerville, Massachusetts. Currently, under construction, the 15-story purpose-built lab office building will contain 465,000 square feet of space. Through incorporating cutting-edge design, services, and amenities, 74M is the next life science development centered in the vibrant Somerville innovation community. Experience state-of-the-art labs that support mission-critical research and development. 74M is LEED Platinum, WELL Platinum, and WiredScore Platinum certified – meeting exceptional standards for infrastructure, energy efficiency, and tenant well-being. The building’s focus isn’t just on scientific advancements but also on the scientists who discover them. On-site amenities include an expansive rooftop lounge and event space featuring expansive skyline views, a well-being center featuring fitness and spa-style facilities, an expansive outdoor terrace, and more. 74M offers easy accessibility and unparalleled visibility directly adjacent to I-93 and a short walk to the MBTA Orange Line station. The development creates connectivity between the highly amenitized Assembly Square and the authentic cafes and restaurants of East Somerville. Enjoy unencumbered views of Boston, Cambridge, and the Mystic River throughout the workday and benefit from proximity to a highly educated and talented workforce. 74M is an ideal destination for today’s innovators within a 10-minute drive of Kendall Square and Logan International Airport.

Date on Market:

2024-03-28

Charlestown Office, Industrial for Lease - Charlestown/East Boston

500 Rutherford Avenue, situated within the Hood Park 20-acre mixed-use urban campus, is a beautifully renovated three-story facility in Charlestown, Massachusetts. Presenting approximately 125,000 square feet of new construction, the 300,000-square-foot building has been re-adapted to serve a diverse user base. Tenants experience a dynamic setting with abundant on-site parking, efficient floor plans, a private lounge area, and high-visibility signage potential. Current availability includes first-generation research and development (R&D), lab, and manufacturing space. Tenants benefit from ample 1,200-amp, 480-volt power and a fully furnished leasing opportunity with office and lab equipment included. There’s also an additional 6,000 square feet of open warehouse/industrial space with a 16-foot clear height that can easily be brought up to code for a variety of uses. Plus, the potential to tie into RODI (Reverse Osmosis Deionization) and pH neutralization systems are available. 500 Rutherford Avenue offers a vibrant and well-connected setting for modern businesses. Tenants enjoy convenient Hood Park amenities like Tradesman Coffee Shop & Pizza Bar, Urban Wild live music venue, Element Salon and Spa, and Hotbox by The Handle Bar fitness studio. The property offers direct Interstate 93 connectivity for swift travel to Downtown Boston and is close to the North Station and Assembly Row commercial hubs. For added convenience, tenants benefit from electric vehicle charging stations and shuttle service to nearby MBTA stations. Combining cutting-edge facilities with desirable amenities, 500 Rutherford Avenue offers an ideal location for businesses seeking a seamless work-life balance.

Date on Market:

2024-11-12

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Choose a prime location in the heart of Cambridge, Massachusetts, with the contemporary office spaces available for lease at 1035 Cambridge Street. This versatile office building offers a unique blend of modern amenities and historic charm, making it an ideal location for businesses of all types. New tenants will be able to join a performing roster of technology, biotech, healthcare, real estate, architecture, coworking, and not-for-profit companies. The available suites at 1035 Cambridge Street come in a wide variety of sizes between 1,518 and 7,136 square feet, with flexible layouts and contemporary features. Most of the units are equipped with private offices, conference rooms, break areas, and open workspaces. Suites come in a variety of finishes, with carpeted or wood flooring, large windows, and attractive built-ins. Tenants at the property enjoy access to a shared conference center facility, common area bathrooms with showers, and abundant on-site parking for 150 vehicles. 1035 Cambridge Street was originally built in 1930 and extensively renovated over the years, spanning a total of 99,500 square feet across three floors. The building’s spacious lobby enters a dramatic two-story atrium with an impressive, oversized skylight and brick and beam finishes, creating a welcoming atmosphere for clients and employees. Tenants have 24/7 access to the property, with card readers and video cameras for security. Centrally located at the heart of Cambridge, 1035 Cambridge Street situates tenants within an established hub near a wealth of quality urban amenities. The location is just a third of a mile from Union Square and Inman Square, both major commercial centers of the region with excellent restaurants and specialty stores. Offering convenient accessibility for commuters, the property sits just a short distance from major highways, including Highway 28 and Interstate 93. Providing additional access options, the site is a short walk from the Union Station Green Line stop, as well as several bus stops, and there are Zipcars and Hubway bikes on-site. Situated approximately 1 mile from both Harvard University and the Massachusetts Institute of Technology, businesses at 1035 Cambridge Street have access to one of the nation’s strongest talent pipelines, which can fuel future growth and expansion. When looking within just 1 mile of the property, tenants can tap into a sizable workforce of more than 68,000, with over 70% of locals carrying a bachelor’s degree or higher. Unlock premier office space at 1035 Cambridge Street, combining modern amenities, flexible layouts, and an unbeatable Cambridge location, with access to top talent, transportation, and vibrant commercial centers. Reach out to the Lee & Associates team today to schedule a tour and find the perfect space.

Date on Market:

2025-11-28

Watertown Office for Lease

Conveniently located in prime Watertown, MA, 66 Galen St is a newly built lab building offering 224,106 RSF with an expansion opportunity of up to 224,000 RSF in Phase II of the campus. Situated on a 5-acre campus plan, including 1 acre of lush green space, this building boasts LEED Gold Certification and approximately 25,000 SF of solar panels, aligning with your sustainability goals. Amenities abound, with a fitness center featuring locker rooms, an outdoor roof deck, and close proximity to biking and running trails.

Date on Market:

2024-03-21

Cambridge Flex for Lease - E Cambridge/Kendall Sq

Brokers Welcome! A clean and well-maintained, privately owned building in the vibrant East Cambridge neighborhood with close proximity to public transportation, Kendall Square and Route 93. Lechmere station is just 7 minutes away on foot, or take the on-site #69 MBTA bus toward Lechmere or Harvard Squares. Great restaurants, coffee shops, markets and grocery stores all within walking distance. Currently 1 Unit Available on November 1, 2025 which includes 4033 Suite B1 and 689 SF Suite 102 ($22.50 NNN + $7.50): Cambridge is finally affordable again! A rare, flexible, low-cost, grandfathered distribution/tech/light manufacturing/contractor/storage/R&D/repair/lab space with plenty of office/desk & conference space in the heart of a dynamic East Cambridge neighborhood. 800 amp, 3-phase 208V electrical service. A dedicated, 6500 lb material lift with 4’ x 8’ car, features a straight shot from the parking/loading area through the 689 sf first floor office space, and down to the lower level’s 4033 sf flex space. Includes 2 lab sinks, kitchen/break room, 3 different HVAC systems with app control. Private restroom with private shower included. First floor features a dedicated office and open conference room space with giant, south-facing windows. Lower level features new, epoxy flooring throughout. Wired networking capable of 10GB and rack space available. Up to 6 parking spaces are available for an additional fee. 24 hour, swipe/prox card secure access. Starter workstations and tables shown in photos may be included as desired. The combined 4722 sf space comes as a single, indivisible unit.

Property Type:

Office

Date on Market:

2025-07-10

Watertown Office for Lease

One of a kind warehouse/office hybrid space. Newton/Watertown line. Garden level. Needs cosmetics but well worth it at this price. Heat and hot water included. Perfect for light industrial, kinder garden, after school, office, etc. 7 parking can be included in rent. Don't miss this! Right off the mass pike highway. In the zone of major biotech development in Watertown Sq. Hard to find a better location or price in this prime area.

Date on Market:

2023-12-28

Cambridge Flex for Lease - E Cambridge/Kendall Sq

Property Type:

Industrial

Date on Market:

2022-07-18

Boston Office, Retail for Lease - Seaport

Positioned in the heart of Boston’s Seaport Innovation District, 7 Channel Center presents a premier opportunity within the established Channel Center Planned Development Area. Surrounded by world-class companies, cultural amenities, and new development, the property is strategically located in one of Boston’s fastest-growing submarkets, driven by strong demand across office, life science, and residential sector

Date on Market:

2025-08-12

Boston Flex for Lease - Seaport

Date on Market:

2025-08-08

Watertown Flex for Lease

Located just off Arsenal Street, 200 Dexter Ave is a two-story Class B office building offering 2,240 square feet of flexible office and lab space. Built in 1977, the property features newly renovated interiors, lab equipment, and 54 parking spots. It provides convenient access to major routes including Soldiers Field Road, the Mass Pike (RT 90), and Route 128, and is minutes from downtown Boston, Logan Airport, and Cambridge. Public transit is easily accessible via the nearby #70 bus. The site is also close to shops and restaurants at Arsenal Yards, making it a well-connected and amenity-rich location for businesses.

Property Type:

Office

Date on Market:

2025-09-03

Charlestown Flex for Lease - Charlestown/East Boston

Brand New Lab, Heavy R&D, and Clean Room space with ability to modify as needed. Heavy Power, Loading, and other infrastructure available. Perfect space for Light Manufacturing, Electronics, Clean Room, and Advanced Manufacturing Groups.

Date on Market:

2025-05-12

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Date on Market:

2024-10-31

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

The Abbot at 18-24 Brattle Street presents a once-in-a-generation opportunity to occupy the most iconic building in the heart of Harvard Square, the epicenter of Cambridge, Massachusetts. Future tenants are invited to discover the tremendous redevelopment potential of this iconic property through a blend of historic preservation with modern amenities. World-class academic institutions, top tech and life science companies, vibrant neighborhoods, and rich cultural diversity surround this dynamic property. Completely renovated from the inside out, suites on the second and fourth floors are immediately available for lease. The building's diverse tenant mix includes creative and professional businesses and national tenants, such as Starbucks, Cava, and F45 Training. Occupancy terms are negotiable, with lease rates available upon request. Building tenants enjoy state-of-the-art HVAC, private outdoor space, operable windows, and more. Historical and cultural offerings, cobblestone streets, and a unique blend of over 350 dining, retail, and entertainment options within a quarter-mile encompass The Abbot. This section of Cambridge is one of the most iconic locations in the market and one of the most accessible. Situated directly across the street from Harvard Square Red Line Station, the third-most active station in the area, tenants have access to over 23,000 daily riders. The Abbot boasts unparalleled traffic and amenities, making it a draw for customers, businesses, and retailers alike.

Date on Market:

2024-06-24

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Available immediately. Premier office/flex space in Cambridge on Sidney St in the heart of MIT. An entire campus for your company composed of two buildings, and featuring dedicated parking spaces. Free-standing buildings ensures that you have not just a private space for your company, but that you also make a strong statement by not having to share your building with any other group and it allows you extraordinary signage opportunities on your own campus; a true rarity in Cambridge. Perfect for life science and technology companies. SD-8 Zoning allows office, lab, R&D, light industry (including manufacturing), educational purposes (including dormitory), medical and health care use, local government use. The building features two floors, and is composed of a mix of closed offices, open spaces, multiple conference rooms, large kitchen area, and multiple bathrooms featuring showers, a dedicated mother’s room, and ample natural light. The space was completely renovated two years ago and has been 100% transformed at that time with the building brought back to the shell, and transformed into an exceptional 1st class setting which was formerly the corporate headquarters for a public life science company. Modern, bright, and functional with careful attention paid to even the smallest details. Architecture designed by Margolis & Fishman; construction performed by Siena. Easily accessible by public transportation, and it has multiple public parking spaces on the street, and there are fifteen dedicated parking spaces as well. A rare opportunity to lease premier space in stand-alone buildings by Central Square, and MIT. Multiple public life science companies are located on Sidney St, and it remains a highly desired area with numerous public companies surrounding it. Open to short and long term leases. Furniture can be left in place for plug and play. All brokers are protected.

Date on Market:

2024-08-16

Boston Industrial for Lease - Seaport

310-312 North Avenue is a class B industrial building that offers refrigerated industrial condominiums in Boston, MA. The 48,882 square foot building has 26,000 square feet, split between 2 condos, available for sale or lease. The building is conveniently located near two bus lines and eight-minutes away from the Boston Logan International Airport, providing easy access for commuting. Additional to the commuter options, the building Is also within a one to eight-minute drive to eight hotels in the area. Tenants can enjoy industrial spaces with cross docks, refrigeration, and redevelopment opportunities. Employees will find themselves within driving distance of restaurants and banks.

Date on Market:

2024-06-20

Watertown Office for Lease

Date on Market:

2024-03-26

Medford Office/Medical for Lease - Medford/Malden

One Cabot Road is a four story, ±316,233 SF class A office building located in the thriving community of Medford, Massachusetts. The property recently underwent a $16.9 million amenity upgrade and now features a new lobby lounge, coffee lounge, new fitness center and locker rooms, expansive outdoor patio and a full-service cafe.

Property Type:

Office

Date on Market:

2024-02-23

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Date on Market:

2023-11-29

Cambridge Office, Flex for Lease - Mid-Cambridge/Harvard Sq

Date on Market:

2025-09-29

Boston Office for Lease - Financial District

Office building located in prime Boston location. Close to many public transportation options.

Date on Market:

2025-08-06

Cambridge Retail for Lease - E Cambridge/Kendall Sq

Immediately north of the site is Cambridge Crossing, a new 43-acre development located at Lechmere Station home to Philips, Bristol Meyers Squibb, REI, Tatte, and Lamplighter Brewing

Property Type:

Office

Date on Market:

2025-11-17

Chelsea Office for Lease - Chelsea/Revere

Tons of area amenities within walking distance from the property. Highly attentive property management. Cost effective office space that Landlord is willing to build out for potential tenants to their required specs. Immediately accessible to the commuter train station, just one stop to North Station. Bus service to Wellington (orange), Haymarket (green) and Wonderland (blue) immediately accessible. Boston Logan International Airport just minutes away. Easy on/off Routes 1, 93 and 16.

Date on Market:

2025-09-02

Boston Office for Lease - Seaport

Seaport Circle is a mixed-use development featuring 650,000 square feet of life science research and office space in Boston's most prominent life science cluster. The project is pursuing LEED Platinum designation, with a 90% reduction in natural gas use. The two-tower design will provide flexible floor plates ranging from 25,000-75,000 square feet. In addition to state-of-the-art Class A lab and office space, the building will include best-in-class tenant amenity spaces and approximately 5,000 square feet of retail space. Seaport Circle will also include a 15,000 SF stand-alone South Boston Waterfront Job Training Pavilion (the Pavilion) with an ambitious mission focused on training for skilled jobs in life sciences and adding talent to the pipeline of opportunity in the Boston area’s exploding life science sector.

Date on Market:

2023-02-06

Newton Office for Lease - Newton/Brookline

Date on Market:

2022-12-12