Commercial Real Estate in Massachusetts available for lease

189 Life Science Properties for Lease in Massachusetts, USA

Life Science Properties for Lease in Massachusetts, USA

More details for 74 Middlesex Ave, Somerville, MA - Office for Lease

74M | Purpose-Built Lab - 74 Middlesex Ave

Somerville, MA 02145

  • Life Science
  • Office for Lease
  • 10,000 - 469,000 SF
  • 1 Space Available Now
  • Bicycle Storage
  • Bio-Tech/ Lab Space
  • Controlled Access
  • Metro/Subway
  • Restaurant
  • Roof Terrace

Somerville Office for Lease - Somerville/Everett

74M is a breakthrough life science development in Somerville, Massachusetts. Currently, under construction, the 15-story purpose-built lab office building will contain 465,000 square feet of space. Through incorporating cutting-edge design, services, and amenities, 74M is the next life science development centered in the vibrant Somerville innovation community. Experience state-of-the-art labs that support mission-critical research and development. 74M is LEED Platinum, WELL Platinum, and WiredScore Platinum certified – meeting exceptional standards for infrastructure, energy efficiency, and tenant well-being. The building’s focus isn’t just on scientific advancements but also on the scientists who discover them. On-site amenities include an expansive rooftop lounge and event space featuring expansive skyline views, a well-being center featuring fitness and spa-style facilities, an expansive outdoor terrace, and more. 74M offers easy accessibility and unparalleled visibility directly adjacent to I-93 and a short walk to the MBTA Orange Line station. The development creates connectivity between the highly amenitized Assembly Square and the authentic cafes and restaurants of East Somerville. Enjoy unencumbered views of Boston, Cambridge, and the Mystic River throughout the workday and benefit from proximity to a highly educated and talented workforce. 74M is an ideal destination for today’s innovators within a 10-minute drive of Kendall Square and Logan International Airport.

Contact:

JLL

Date on Market:

2024-03-28

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More details for 1 Research Dr, Westborough, MA - Office for Lease
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One Research Drive - 1 Research Dr

Westborough, MA 01581

  • Life Science
  • Office for Lease
  • 15,199 - 99,643 SF
  • 5 Spaces Available Now
  • Energy Performance: A
  • Air Conditioning
  • Natural Light
  • Security System
  • Bio-Tech/ Lab Space
  • Drop Ceiling
  • 24 Hour Access
  • Fitness Center
  • Conferencing Facility
  • Reception

Westborough Office for Lease - The Boroughs

One Research Drive is a four-story, 283,797-square-foot Class A office building in the heart of the Westborough Business Park. It offers unmatched accessibility, modern amenities, and professional management. Visible from Route 9 and minutes from Interstate 495 and the Massachusetts Turnpike, the property's prime location ensures frictionless connectivity to Boston and surrounding areas. Designed to meet the evolving needs of today's workforce, One Research Drive has undergone significant capital improvements, including a fully renovated lobby, LED lighting upgrades, glass railing systems, modernized common areas, enhanced restrooms, and updated HVAC systems. The property features best-in-class amenities, such as a 140-seat auditorium, an executive boardroom with catering space, a full-service cafeteria with an outdoor patio, high-speed wireless internet in common areas, and a well-equipped fitness center with locker rooms and showers. Additional conveniences include an on-site ATM, abundant surface parking, and an elevated walkway that leads to the third-floor lobby entrance. One Research Drive tenants benefit from convenient public transit access, with the WRTA shuttle providing direct service from the MBTA Westborough Commuter Rail Station. As a recipient of the Energy Star label since 2007, One Research Drive remains committed to sustainability, with plans for EV chargers and expanded renewable energy initiatives. Professionally managed by Ferris Development Group, this premier office destination offers a dynamic, well-connected, and energy-efficient workplace designed for success.

Contact:

Ferris Development Group, LLC

Date on Market:

2026-05-19

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More details for 1 Research Dr, Westborough, MA - Office for Lease

One Research Drive - 1 Research Dr

Westborough, MA 01581

  • Life Science
  • Office for Lease
  • 33,105 SF
  • 1 Space Available Now
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More details for 27 Congress St, Salem, MA - Multiple Space Uses for Lease
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Shetland Park - 27 Congress St

Salem, MA 01970

  • Life Science
  • Multiple Space Uses for Lease
  • $18.13 - $26.49 CAD SF/YR
  • 241 - 383,339 SF
  • 35 Spaces Available Now
  • Air Conditioning
  • Natural Light
  • Drop Ceiling
  • Commuter Rail
  • Private Restrooms
  • 24 Hour Access
  • Kitchen
  • Reception
  • Waterfront
  • Wheelchair Accessible

Salem Multiple Space Uses for Lease - Peabody/Salem

Situated on a sprawling 30-acre oceanfront property across five distinct buildings, Shetland Park is a prestigious 1.5 million-square-foot business center. Versatile office, flex, and industrial space is currently available for lease in various ranges, from private suites to large blocks. Tenants have the exciting opportunity to craft modern, unique workspaces with mesmerizing views of the harbor in flexible configurations. Key property features include surface and covered parking, 24-hour access, high-speed internet, upgraded common areas, and on-site security. Flex users can access tailboard loading and 14- to 23-foot ceiling heights. This dynamic campus also features health and wellness professionals, a full-service salon, a caterer, a gym, a cross-fit facility, an event space, and a childcare center. For businesses seeking a prominent setting with picturesque views, Shetland Park presents the ideal opportunity. Its prime location near Salem's flourishing downtown amenities enhances the overall appeal. Space is immediately available for tenant occupancy and offered at competitive lease rates alongside attractive tenant improvement packages. Shetland Park's Salem Harbor location adds to the allure of the property, fostering a unique business/lifestyle atmosphere with easy access to restaurants and shops. Moreover, tenants enjoy swift connectivity to Route 128 and a mere 35-minute drive south to Downtown Boston. Mass transit users find that traveling to and from the property is a breeze as the Salem MBTA station, with commuter rail and bus access, is within convenient walking distance. The campus's prestige, attractive rates, and excellent accessibility make Shetland Park a highly desirable business center within vibrant surroundings. This property is a must-see, with showings available by appointment only.

Contacts:

Nordlund Associates, Inc.

Prime Group Shetland Park

Date on Market:

2026-02-19

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More details for 60 Fremont St, Worcester, MA - Multiple Space Uses for Lease
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The Landing at Worcester Mills - 60 Fremont St

Worcester, MA 01603

  • Life Science
  • Industrial for Lease
  • 3,000 - 37,757 SF
  • 3 Spaces Available Now
  • Air Conditioning
  • Security System
  • Controlled Access

Worcester Multiple Space Uses for Lease - Worcester Metro

The Landing at Worcester Mills, located at 60 Fremont Street, introduces a rare mixed-use leasing opportunity within a newly revitalized asset offering warehouse, storage, office, and creative loft studios designed for maximum flexibility. Under new ownership and management, the property benefits from a well-capitalized team prepared to retrofit and build space to meet a wide range of user needs, including office, lab, manufacturing, logistics, and last-mile distribution. The building features up to 18-foot warehouse ceiling heights, a substantial first-floor warehouse footprint ideal for an anchor tenant with loading access, a second floor suited for office, workshop, or light industrial use, and a third floor fully dedicated to flex space with high ceilings and oversized windows that deliver abundant natural light. Additional basement space, ample on-site parking, resurfaced lots, two freight elevators, and robust power support operational efficiency. The Landing at Worcester Mills offers functional, flexible spaces ranging from 3,000 to over 17,000 square feet, accommodating a wide variety of occupants. Ideally situated in central Massachusetts, 60 Fremont Street delivers exceptional connectivity and distribution access throughout New England. The site is minutes from Interstates 290, 90 (Mass Pike), and 495, and Routes 20, 12, and 9, placing regional markets within reach. Downtown Worcester, Polar Park, and Union Station are approximately a 10-minute drive, providing access to Amtrak, MBTA Commuter Rail, and regional bus lines. Freight and air logistics are supported by proximity to the CSX Worcester Rail Yard and Worcester Regional Airport, both within a short drive, with Boston Logan International Airport and the Port of Boston accessible within an hour. The surrounding area offers strong day-to-day conveniences, including national retailers such as Shaw’s, CVS, Marshalls, and Planet Fitness, while downtown continues to expand with new residential development and amenities. Located within a growing and business-friendly market, The Landing at Worcester Mills benefits from Worcester’s expanding population and a labor force exceeding 203,000 within a 10-mile radius. The city’s strong academic presence, anchored by institutions such as Worcester Polytechnic Institute, College of the Holy Cross, Worcester State University, and Quinsigamond Community College, supports a deep and educated talent pipeline for healthcare, biotech, technology, and advanced manufacturing users. Worcester’s position as a gateway city to the Northeast enables faster deliveries, broader reach, and lower freight and logistics costs, reinforced by significant transportation infrastructure. Local and state programs further enhance the opportunity through potential tax incentives for qualifying job-creating investments. The Landing at Worcester Mills is ideal for companies seeking space that can evolve.

Contact:

Manzo Freeman Development, LLC.

Date on Market:

2026-04-03

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More details for 705 Mount Auburn St, Watertown, MA - Office, Flex for Lease
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705 Mount Auburn St

Watertown, MA 02472

  • Life Science
  • Office for Lease
  • 10,000 - 488,081 SF
  • 1 Space Available Now
  • Air Conditioning
  • Bio-Tech/ Lab Space
  • Car Charging Station

Watertown Office, Flex for Lease

705 Mount Auburn Street is a fully repositioned professional campus totaling approximately 492,000 square feet across six stories in East Watertown. Originally constructed in 1930 and comprehensively redeveloped and modernized through 2025, the property has been transformed into a next-generation research and innovation hub designed to support office, research and development (R&D), lab, manufacturing, and GMP-level operations. The redevelopment includes significant infrastructure upgrades and an expansive amenity program, including a café, fitness center, conference facilities, food hall, collaborative outdoor spaces, and direct access to the Watertown Greenway. 705 Mount Auburn Street is strategically located with proximity to Cambridge, Downtown Boston, and major life-science clusters. The property combines urban accessibility with suburban convenience and offers abundant on-site parking for tenants and visitors. Major employers in the area significantly benefit from the robust workforce in the immediate area, fueled by some of the nation’s top research institutions, such as Harvard University, MIT, Boston University, and Northeastern University. As a world-class education hub, Boston ranks among the nation's highest, with over 52% of residents holding a bachelor's degree and an average household income exceeding $133,900. The Boston Market is home to world-class institutions in education, healthcare, biotechnology, and financial services. Major employers in the metro include Biogen, Deloitte, BAE Systems, Vertex Pharmaceuticals, Fidelity Investments, and General Electric.

Contact:

Newmark

Date on Market:

2025-10-02

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More details for 15-45 Dan Rd, Canton, MA - Office for Lease
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Canton Corporate Place - 15-45 Dan Rd

Canton, MA 02021

  • Life Science
  • Office for Lease
  • $22.83 CAD SF/YR
  • 1,997 - 69,682 SF
  • 8 Spaces Available Now
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More details for 50 Thomas Patten Dr, Randolph, MA - Office/Medical for Lease
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50 Thomas Patten Dr

Randolph, MA 02368

  • Life Science
  • Office/Medical for Lease
  • $32.07 CAD SF/YR
  • 6,000 - 8,000 SF
  • 1 Space Available Now
  • Air Conditioning
  • Security System
  • Private Restrooms
  • 24 Hour Access
  • Controlled Access
  • Kitchen
  • Reception
  • Wheelchair Accessible

Randolph Office/Medical for Lease - Route 24

50 Thomas Patten Drive is a professional office and lab building in Randolph, Massachusetts. The two-story building contains nearly 30,000 square feet and was completely renovated in 2019. Recent upgrades to the landscaping, façade, and bathrooms, along with ample surface parking, impress both employees and clients visiting this exceptionally maintained property. Up to 15,000 square feet of first-floor, mixed-use office and lab space is immediately available for occupancy. This space is in move-in-ready condition or can be customized to exact specifications. Benefit from 36 large cubicles that are pre-wired for networking and professionally cleaned, 13 spacious perimeter offices, and a generous conference room. The first floor also boasts lab space with a fire suppression system and access to a loading dock. The all-inclusive rent includes heat, hot water, electricity, taxes, and no surprises. 50 Thomas Patten Drive sits 20 miles south of Boston. Commuters can reach Route 24 within a three-minute drive and benefit from convenient access to Route 3 and Interstates 95 and 93. Surrounding amenities, like Dunkin', Outback Steakhouse, a United States Postal Service office, Holiday Inn Express, Showcase Cinema de Lux, and the Randolph Dog Park are only a short drive away.

Contact:

Whitridge Associates

Property Type:

Office

Date on Market:

2019-01-09

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More details for 300 Jubilee Dr, Peabody, MA - Industrial for Lease
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Warehouse Sublease - 300 Jubilee Dr

Peabody, MA 01960

  • Life Science
  • Industrial for Lease
  • 51,795 SF
  • 1 Space Available Now
  • Air Conditioning
  • Natural Light
  • Private Restrooms

Peabody Industrial for Lease - Peabody/Salem

300 Jubilee Drive presents a 51,795-square-foot warehouse sublease opportunity within a high-quality industrial/flex asset in Peabody, Massachusetts. The space offers a flexible platform suited for distribution, light manufacturing, research and development (R&D), assembly, product staging, and hybrid office-industrial users. The facility is equipped with a practical, clear-height mix that provides operational flexibility with a 30-foot section supporting higher-bay warehouse, production, and distribution functions, while the 16-foot section accommodates complementary flex, production, staging, technical, or support uses. The building delivers a strong parking ratio, high-end curb appeal with a full glass curtain wall, and a landscaped, tree-lined patio with outdoor seating. This sublease is a rare opportunity to secure a functional, design-forward industrial space in Centennial Park. Located within one of New England’s most critical logistics corridors, 300 Jubilee Drive sits within a quarter-mile of Route 1 and the Interstate 95/Route 128 interchange, providing immediate highway connectivity and seamless regional access. This infrastructure enables efficient truck circulation, reduced transit times, and lower logistics costs while supporting last-mile distribution to Greater Boston and surrounding markets. The site is within a 30-minute drive of Boston, Cambridge, and southern New Hampshire, and 15 miles from Boston Logan International Airport. The surrounding area offers immediate access to a wide range of amenities, including Northshore Mall, Santarpio’s Pizza, Sonic, Wendy’s, Hampton Inn, and Holiday Inn & Suites, all within 3 miles. A dense population of more than 800,000 within a 10-mile radius supports labor availability. Centennial Park stands as one of the North Shore’s premier business hubs, home to a diverse mix of manufacturing, biotech, logistics, and R&D users, including Cardinal Health, Analogic, and Thermo Fisher Scientific. This established industrial cluster enhances access to a skilled labor pool. The surrounding market benefits from strong fundamentals driven by proximity to Boston and sustained demand for last-mile industrial space. This sublease opportunity combines scale, flexibility, and a premier location within a high-performing industrial ecosystem.

Contact:

Wronka, Ltd. Commercial Real Estate Advisors

Date on Market:

2026-04-30

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More details for 12 Gill St, Woburn, MA - Office, Flex for Lease

Lab, R&D, and Office - 12 Gill St

Woburn, MA 01801

  • Life Science
  • Office for Lease
  • 1,443 - 61,034 SF
  • 5 Spaces Available Now
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More details for 200 Exchange St, Malden, MA - Office for Lease
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Exchange 200 - 200 Exchange St

Malden, MA 02148

  • Life Science
  • Office for Lease
  • 11,000 - 174,440 SF
  • 4 Spaces Available Now
  • Bio-Tech/ Lab Space

Malden Office for Lease - Medford/Malden

Discover Exchange 200, offering state-of-the-art lab, GMPc, R&D, and creative office space with robust infrastructure, steps from transit. Exchange 200 is complete and ready to accommodate the requirements of today’s growing life sciences and technology tenants. The development site is situated at an outstanding transit-oriented location directly across from the Malden Center T-Station, with direct access to the MBTA Orange Line, Commuter Rail, bus connections, and bike paths. Travel to Downtown Boston in just 12 minutes, only one stop from North Station on the Commuter Rail or five stops on the Orange Line. Exchange 200 has undergone a transformative redevelopment that firmly establishes the 300,000 SF building as the next destination for Greater Boston’s cutting edge companies. Featuring state-of-the-art new building systems, a two-story lobby, fitness center, bike storage and a host of other, first-class amenities that appeal to today’s life sciences and creative office workforce, the reimagined space offers a vibrant work environment, bolstered by activated ground-floor retail with outdoor seating. Anchored by the renowned coffee house, Starbucks, tenants can enjoy this well-known laid-back atmosphere as a place to meet up with colleagues, grab a bite to eat, or relax without ever having to leave the building. Two full-service restaurants, Evviva Trattoria and 110 Grill, offer an extensive variety of food options along with vibrant outdoor patio spaces. Malden is a diverse community, emerging as a new residential and commercial hotspot with over 1,000 new luxury residential units. Just five miles from Boston, enjoy the charm of a small town and the amenities of one of America's largest cities.

Contact:

JLL

Date on Market:

2024-06-11

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More details for 200 Boston Ave, Medford, MA - Office, Flex for Lease

Existing and Build-to-Suit Lab - 200 Boston Ave

Medford, MA 02155

  • Life Science
  • Flex for Lease
  • 517 - 48,374 SF
  • 9 Spaces Available Now
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More details for 66 Galen St, Watertown, MA - Office for Lease

66 Galen St

Watertown, MA 02472

  • Life Science
  • Office for Lease
  • 12,490 SF
  • 1 Space Available Now
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More details for 411 Waverley Oaks Rd, Waltham, MA - Flex for Lease

Building 1 - 411 Waverley Oaks Rd

Waltham, MA 02452

  • Life Science
  • Flex for Lease
  • 3,000 - 30,096 SF
  • 4 Spaces Available Now
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More details for 10 Cordage Park, Plymouth, MA - Office for Lease

Cordage Commerce Center - 10 Cordage Park

Plymouth, MA 02360

  • Life Science
  • Office for Lease
  • 1,793 - 23,525 SF
  • 7 Spaces Available Now
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More details for 378 Page St, Stoughton, MA - Industrial for Lease
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378 Page St

Stoughton, MA 02072

  • Life Science
  • Industrial for Lease
  • $16.73 CAD SF/YR
  • 5,000 - 10,000 SF
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More details for 500 Rutherford Ave, Charlestown, MA - Office, Industrial for Lease

500 Rutherford Ave

Charlestown, MA 02129

  • Life Science
  • Office for Lease
  • 6,500 - 21,500 SF
  • 2 Spaces Available Now
  • Air Conditioning
  • Bio-Tech/ Lab Space
  • Fitness Center
  • Restaurant
  • Wheelchair Accessible

Charlestown Office, Industrial for Lease - Charlestown/East Boston

500 Rutherford Avenue, situated within the Hood Park 20-acre mixed-use urban campus, is a beautifully renovated three-story facility in Charlestown, Massachusetts. Presenting approximately 125,000 square feet of new construction, the 300,000-square-foot building has been re-adapted to serve a diverse user base. Tenants experience a dynamic setting with abundant on-site parking, efficient floor plans, a private lounge area, and high-visibility signage potential. Current availability includes first-generation research and development (R&D), lab, and manufacturing space. Tenants benefit from ample 1,200-amp, 480-volt power and a fully furnished leasing opportunity with office and lab equipment included. There’s also an additional 6,000 square feet of open warehouse/industrial space with a 16-foot clear height that can easily be brought up to code for a variety of uses. Plus, the potential to tie into RODI (Reverse Osmosis Deionization) and pH neutralization systems are available. 500 Rutherford Avenue offers a vibrant and well-connected setting for modern businesses. Tenants enjoy convenient Hood Park amenities like Tradesman Coffee Shop & Pizza Bar, Urban Wild live music venue, Element Salon and Spa, and Hotbox by The Handle Bar fitness studio. The property offers direct Interstate 93 connectivity for swift travel to Downtown Boston and is close to the North Station and Assembly Row commercial hubs. For added convenience, tenants benefit from electric vehicle charging stations and shuttle service to nearby MBTA stations. Combining cutting-edge facilities with desirable amenities, 500 Rutherford Avenue offers an ideal location for businesses seeking a seamless work-life balance.

Contact:

Rise 73

Date on Market:

2024-11-12

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More details for 1035 Cambridge St, Cambridge, MA - Office for Lease

1035 Cambridge Street Offices - 1035 Cambridge St

Cambridge, MA 02141

  • Life Science
  • Office for Lease
  • 1,343 - 25,371 SF
  • 8 Spaces Available Now
  • Air Conditioning
  • Natural Light
  • Bio-Tech/ Lab Space
  • 24 Hour Access
  • Conferencing Facility
  • Controlled Access

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Choose a prime location in the heart of Cambridge, Massachusetts, with the contemporary office spaces available for lease at 1035 Cambridge Street. This versatile office building offers a unique blend of modern amenities and historic charm, making it an ideal location for businesses of all types. New tenants will be able to join a performing roster of technology, biotech, healthcare, real estate, architecture, coworking, and not-for-profit companies. The available suites at 1035 Cambridge Street come in a wide variety of sizes between 1,343 and 7,136 square feet, with flexible layouts and contemporary features. Most of the units are equipped with private offices, conference rooms, break areas, and open workspaces. Suites come in a variety of finishes, with carpeted or wood flooring, large windows, and attractive built-ins. Tenants at the property enjoy access to a shared conference center facility, common area bathrooms with showers, and abundant on-site parking for 150 vehicles. 1035 Cambridge Street was originally built in 1930 and extensively renovated over the years, spanning a total of 99,500 square feet across three floors. The building’s spacious lobby enters a dramatic two-story atrium with an impressive, oversized skylight and brick and beam finishes, creating a welcoming atmosphere for clients and employees. Tenants have 24/7 access to the property, with card readers and video cameras for security. Centrally located at the heart of Cambridge, 1035 Cambridge Street situates tenants within an established hub near a wealth of quality urban amenities. The location is just a third of a mile from Union Square and Inman Square, both major commercial centers of the region with excellent restaurants and specialty stores. Offering convenient accessibility for commuters, the property sits just a short distance from major highways, including Highway 28 and Interstate 93. Providing additional access options, the site is a short walk from the Union Station Green Line stop, as well as several bus stops, and there are Zipcars and Hubway bikes on-site. Situated approximately 1 mile from both Harvard University and the Massachusetts Institute of Technology, businesses at 1035 Cambridge Street have access to one of the nation’s strongest talent pipelines, which can fuel future growth and expansion. When looking within just 1 mile of the property, tenants can tap into a sizable workforce of more than 68,000, with over 70% of locals carrying a bachelor’s degree or higher. Unlock premier office space at 1035 Cambridge Street, combining modern amenities, flexible layouts, and an unbeatable Cambridge location, with access to top talent, transportation, and vibrant commercial centers. Reach out to the Lee & Associates team today to schedule a tour and find the perfect space.

Contact:

Lee & Associates Boston

Date on Market:

2026-02-02

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More details for 300-400 Tradecenter, Woburn, MA - Office, Flex for Lease

Office and Lab - 300-400 Tradecenter

Woburn, MA 01801

  • Life Science
  • Office for Lease
  • 851 - 34,510 SF
  • 8 Spaces Available Now
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More details for 100 Cummings Ctr, Beverly, MA - Office, Flex for Lease

100 Cummings Center - 100 Cummings Ctr

Beverly, MA 01915

  • Life Science
  • Office for Lease
  • 157 - 50,351 SF
  • 20 Spaces Available Now
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More details for 100 Cummings Ctr, Beverly, MA - Coworking for Lease

Fully Furnished Offices - 100 Cummings Ctr

Beverly, MA 01915

  • Life Science
  • Coworking for Lease
  • 220 - 940 SF
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More details for 100 Crowley Dr, Marlborough, MA - Office for Lease

100 Crowley Dr

Marlborough, MA 01752

  • Life Science
  • Office for Lease
  • $27.54 CAD SF/YR
  • 1,251 - 80,273 SF
  • 5 Spaces Available Now
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More details for 13-15 DeAngelo Dr, Bedford, MA - Flex for Lease

13-15 DeAngelo Dr

Bedford, MA 01730

  • Life Science
  • Flex for Lease
  • $30.68 CAD SF/YR
  • 31,000 SF
  • 1 Space Available Now
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More details for 100 Corporate Pl, Peabody, MA - Office/Medical, Flex for Lease

Peabody Corporate Center - 100 Corporate Pl

Peabody, MA 01960

  • Life Science
  • Office/Medical and Flex for Lease
  • $30.68 CAD SF/YR
  • 1,459 - 15,089 SF
  • 6 Spaces Available Now
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