1 Life Science for Lease in Brookline, MA, USA

74M | Purpose-Built Lab - 74 Middlesex Ave

Somerville, MA 02145

• Life Science
• Office for Lease
• 10,000 - 469,000 SF
• 1 Space Available Now

• Bicycle Storage
• Bio-Tech/ Lab Space
• Controlled Access
• Metro/Subway
• Restaurant
• Roof Terrace

Somerville Office for Lease - Somerville/Everett

74M is a breakthrough life science development in Somerville, Massachusetts. Currently, under construction, the 15-story purpose-built lab office building will contain 465,000 square feet of space. Through incorporating cutting-edge design, services, and amenities, 74M is the next life science development centered in the vibrant Somerville innovation community. Experience state-of-the-art labs that support mission-critical research and development. 74M is LEED Platinum, WELL Platinum, and WiredScore Platinum certified – meeting exceptional standards for infrastructure, energy efficiency, and tenant well-being. The building’s focus isn’t just on scientific advancements but also on the scientists who discover them. On-site amenities include an expansive rooftop lounge and event space featuring expansive skyline views, a well-being center featuring fitness and spa-style facilities, an expansive outdoor terrace, and more. 74M offers easy accessibility and unparalleled visibility directly adjacent to I-93 and a short walk to the MBTA Orange Line station. The development creates connectivity between the highly amenitized Assembly Square and the authentic cafes and restaurants of East Somerville. Enjoy unencumbered views of Boston, Cambridge, and the Mystic River throughout the workday and benefit from proximity to a highly educated and talented workforce. 74M is an ideal destination for today’s innovators within a 10-minute drive of Kendall Square and Logan International Airport.

Contact:

JLL

Date on Market:

2024-03-28

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• Matterport 3D Tour

705 Mount Auburn St

Watertown, MA 02472

• Life Science
• Office for Lease
• 10,000 - 488,081 SF
• 1 Space Available Now

• Air Conditioning
• Bio-Tech/ Lab Space
• Car Charging Station

Watertown Office, Flex for Lease

705 Mount Auburn Street is a fully repositioned professional campus totaling approximately 492,000 square feet across six stories in East Watertown. Originally constructed in 1930 and comprehensively redeveloped and modernized through 2025, the property has been transformed into a next-generation research and innovation hub designed to support office, research and development (R&D), lab, manufacturing, and GMP-level operations. The redevelopment includes significant infrastructure upgrades and an expansive amenity program, including a café, fitness center, conference facilities, food hall, collaborative outdoor spaces, and direct access to the Watertown Greenway. 705 Mount Auburn Street is strategically located with proximity to Cambridge, Downtown Boston, and major life-science clusters. The property combines urban accessibility with suburban convenience and offers abundant on-site parking for tenants and visitors. Major employers in the area significantly benefit from the robust workforce in the immediate area, fueled by some of the nation’s top research institutions, such as Harvard University, MIT, Boston University, and Northeastern University. As a world-class education hub, Boston ranks among the nation's highest, with over 52% of residents holding a bachelor's degree and an average household income exceeding $133,900. The Boston Market is home to world-class institutions in education, healthcare, biotechnology, and financial services. Major employers in the metro include Biogen, Deloitte, BAE Systems, Vertex Pharmaceuticals, Fidelity Investments, and General Electric.

Contact:

Newmark

Date on Market:

2025-10-02

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684 Massachusetts Ave

Cambridge, MA 02139

• Life Science
• Office/Retail for Lease
• $81.22 CAD SF/YR
• 3,000 SF
• 1 Space Available Now

• Air Conditioning
• Security System
• Bio-Tech/ Lab Space
• Day Care
• 24 Hour Access
• Fitness Center
• Display Window
• Wheelchair Accessible
• Smoke Detector

Cambridge Office/Retail for Lease - Mid-Cambridge/Harvard Sq

684 Massachusetts Avenue presents a highly visible commercial leasing opportunity in the heart of Central Square, offering 3,000 square feet on the ground floor and an additional 2,000 square feet of lower-level space. Formerly occupied by Daily Table Grocery and, prior to that, a long-standing Au Bon Pain, the space has a full build-out with infrastructure, including a freight elevator, large freezer, break room, and extensive storage, supporting a wide range of uses. The building accommodates retail, restaurant, medical, wellness, office, lab, or service concepts, making it an adaptable platform for operators seeking both functionality and exposure. 684 Massachusetts Avenue is a standout opportunity for tenants seeking a successful, public-facing location in Cambridge. Situated directly on Massachusetts Avenue, Cambridge’s primary retail and pedestrian spine, 684 Massachusetts Avenue sits immediately adjacent to the Central Square MBTA Red Line Station and is served by multiple bus routes. The intersection of Massachusetts Avenue with nearby Magazine Street, River Street, and Western Avenue reinforces its connectivity. National retailers such as Starbucks, Amazon, Citizens Bank, and Bank of America are nearby and drive daily traffic. Within minutes are MIT, Kendall Square, and Harvard Square, along with major employers such as Novartis, Pfizer, Takeda, Microsoft, Amgen, and numerous startups, driving consumer demand. Central Square stands as one of Cambridge’s most vibrant and resilient commercial districts, supported by dense residential neighborhoods, academic institutions, and a globally recognized innovation economy. The property serves a population of over 250,000 residents within a 2-mile radius, backed by $3.7 billion in annual consumer spending and a median household income of $109,000, creating a powerful foundation for sustained business performance. This rare opportunity combines proven retail success, multi-use flexibility, and unmatched transit access in one of Greater Boston’s most dynamic markets. 684 Massachusetts Avenue offers tenants the chance to anchor their operations at the crossroads of innovation, community, and commerce.

Contact:

Central Property Management LLC

Property Type:

Office

Date on Market:

2026-02-26

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1035 Cambridge Street Offices - 1035 Cambridge St

Cambridge, MA 02141

• Life Science
• Office for Lease
• 1,343 - 25,371 SF
• 8 Spaces Available Now

• Air Conditioning
• Natural Light
• Bio-Tech/ Lab Space
• 24 Hour Access
• Conferencing Facility
• Controlled Access

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Choose a prime location in the heart of Cambridge, Massachusetts, with the contemporary office spaces available for lease at 1035 Cambridge Street. This versatile office building offers a unique blend of modern amenities and historic charm, making it an ideal location for businesses of all types. New tenants will be able to join a performing roster of technology, biotech, healthcare, real estate, architecture, coworking, and not-for-profit companies. The available suites at 1035 Cambridge Street come in a wide variety of sizes between 1,343 and 7,136 square feet, with flexible layouts and contemporary features. Most of the units are equipped with private offices, conference rooms, break areas, and open workspaces. Suites come in a variety of finishes, with carpeted or wood flooring, large windows, and attractive built-ins. Tenants at the property enjoy access to a shared conference center facility, common area bathrooms with showers, and abundant on-site parking for 150 vehicles. 1035 Cambridge Street was originally built in 1930 and extensively renovated over the years, spanning a total of 99,500 square feet across three floors. The building’s spacious lobby enters a dramatic two-story atrium with an impressive, oversized skylight and brick and beam finishes, creating a welcoming atmosphere for clients and employees. Tenants have 24/7 access to the property, with card readers and video cameras for security. Centrally located at the heart of Cambridge, 1035 Cambridge Street situates tenants within an established hub near a wealth of quality urban amenities. The location is just a third of a mile from Union Square and Inman Square, both major commercial centers of the region with excellent restaurants and specialty stores. Offering convenient accessibility for commuters, the property sits just a short distance from major highways, including Highway 28 and Interstate 93. Providing additional access options, the site is a short walk from the Union Station Green Line stop, as well as several bus stops, and there are Zipcars and Hubway bikes on-site. Situated approximately 1 mile from both Harvard University and the Massachusetts Institute of Technology, businesses at 1035 Cambridge Street have access to one of the nation’s strongest talent pipelines, which can fuel future growth and expansion. When looking within just 1 mile of the property, tenants can tap into a sizable workforce of more than 68,000, with over 70% of locals carrying a bachelor’s degree or higher. Unlock premier office space at 1035 Cambridge Street, combining modern amenities, flexible layouts, and an unbeatable Cambridge location, with access to top talent, transportation, and vibrant commercial centers. Reach out to the Lee & Associates team today to schedule a tour and find the perfect space.

Contact:

Lee & Associates Boston

Date on Market:

2026-02-02

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66 Galen St

Watertown, MA 02472

• Life Science
• Office for Lease
• 12,490 SF
• 1 Space Available Now

• Air Conditioning
• Bicycle Storage
• Bio-Tech/ Lab Space
• Private Restrooms
• Fitness Center
• LEED Certified - Gold
• Wheelchair Accessible

Watertown Office for Lease

Conveniently located in prime Watertown, MA, 66 Galen St is a newly built lab building offering 224,106 RSF with an expansion opportunity of up to 224,000 RSF in Phase II of the campus. Situated on a 5-acre campus plan, including 1 acre of lush green space, this building boasts LEED Gold Certification and approximately 25,000 SF of solar panels, aligning with your sustainability goals. Amenities abound, with a fitness center featuring locker rooms, an outdoor roof deck, and close proximity to biking and running trails.

Contact:

JLL

Date on Market:

2024-03-21

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Building 1 - 411 Waverley Oaks Rd

Waltham, MA 02452

• Life Science
• Flex for Lease
• 3,000 - 33,239 SF
• 5 Spaces Available Now

• Air Conditioning
• Bio-Tech/ Lab Space
• Commuter Rail
• Metro/Subway
• Wheelchair Accessible

Waltham Flex for Lease

This impressive flex property offers a versatile space ideal for a wide range of business needs. Built in 1975, the building encompasses 207,600 square feet and is situated on a generous 7.28-acre lot. With a clear height of 20 feet and 25-foot by 25-foot column spacing, the space is well-suited for both office and industrial applications. The property includes six drive-in bays, providing easy access for loading and unloading, and features ample parking with 345 standard spaces, ensuring convenience for employees and visitors alike. Explore the potential of this flexible space to elevate your business operations!

Contact:

Cushman & Wakefield

Date on Market:

2025-08-13

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500 Rutherford Ave

Charlestown, MA 02129

• Life Science
• Office for Lease
• 6,500 - 21,500 SF
• 2 Spaces Available Now

• Air Conditioning
• Bio-Tech/ Lab Space
• Fitness Center
• Restaurant
• Wheelchair Accessible

Charlestown Office, Industrial for Lease - Charlestown/East Boston

500 Rutherford Avenue, situated within the Hood Park 20-acre mixed-use urban campus, is a beautifully renovated three-story facility in Charlestown, Massachusetts. Presenting approximately 125,000 square feet of new construction, the 300,000-square-foot building has been re-adapted to serve a diverse user base. Tenants experience a dynamic setting with abundant on-site parking, efficient floor plans, a private lounge area, and high-visibility signage potential. Current availability includes first-generation research and development (R&D), lab, and manufacturing space. Tenants benefit from ample 1,200-amp, 480-volt power and a fully furnished leasing opportunity with office and lab equipment included. There’s also an additional 6,000 square feet of open warehouse/industrial space with a 16-foot clear height that can easily be brought up to code for a variety of uses. Plus, the potential to tie into RODI (Reverse Osmosis Deionization) and pH neutralization systems are available. 500 Rutherford Avenue offers a vibrant and well-connected setting for modern businesses. Tenants enjoy convenient Hood Park amenities like Tradesman Coffee Shop & Pizza Bar, Urban Wild live music venue, Element Salon and Spa, and Hotbox by The Handle Bar fitness studio. The property offers direct Interstate 93 connectivity for swift travel to Downtown Boston and is close to the North Station and Assembly Row commercial hubs. For added convenience, tenants benefit from electric vehicle charging stations and shuttle service to nearby MBTA stations. Combining cutting-edge facilities with desirable amenities, 500 Rutherford Avenue offers an ideal location for businesses seeking a seamless work-life balance.

Contact:

Rise 73

Date on Market:

2024-11-12

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Turn-Key Restaurant - Inman Square - 1248-1260 Cambridge St

Cambridge, MA 02139

• Life Science
• Retail for Lease
• $82.59 CAD SF/YR
• 2,372 SF
• 1 Space Available Now

• Air Conditioning
• Wheelchair Accessible

Cambridge Retail for Lease - Mid-Cambridge/Harvard Sq

This fully equipped restaurant and bar includes 40 beer taps, a beer cooler with storage for 40 kegs, high-speed kiddie exhaust system,and a grease trap. A complete list of equipment is available upon request Storage:The facility has a walk-in refrigerator and freezer located in the basement. *Liquor License: Full liquor license issued by the City of Cambridge. Seating Capacity: The establishment can accommodate 99 diners plus bar seating Location: The restaurant is located in the Restaurant Hub of Cambridge, specifically in Inman Square, which is in close proximity to MIT and Harvard University. Nearby Amenities and Restaurants: - Christina’s Homemade Ice Cream - All Star Sandwich Bar - All Star Pizza Bar - Inman Square Wine & Spirits - Casa Portugal Restaurant - Puritan Oyster Bar - Oak Bistro - Christina’s Spice & Specialty Foods - East Cambridge Savings Bank - The Druid - CHA Cambridge Hospital - And many more. **Operational History:** The property has been grandfathered as a restaurant since 1986. Parking: There are 4 on-site parking spaces available, with additional parking options nearby after 5:00 PM. Loading Area: The loading area is located in the parking lot. Traffic Count: Approximately 22,358 vehicles pass through the intersection of Cambridge and Prospect Streets daily. **Utilities: The property has separately metered utilities for electricity, water, and gas. Water & Sewer Services: These services are provided by the City of Cambridge.

Contact:

Godino & Company, Inc.

Date on Market:

2025-01-24

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