19 Life Science Properties for Lease in Durham, NC, USA

Durham Office/Medical for Lease - North Durham

Discover the Research Triangle’s generative life science, research, and healthcare ecosystem from a highly connected perspective at Independence Park. Located at 4233 Technology Drive, Independence Park is a 22,587-square-foot, single-tenant facility comprising second-generation lab, cleanroom manufacturing, and office space with robust infrastructure and a utility yard. Independence Park is equipped to handle even the most intensive operations, such as advanced manufacturing, biotech R&D, pharmaceuticals, and more. The facility is served by a drive-in loading door with an over 20-foot clearance height, an equipment mezzanine, and a 300-kilowatt generator. Additional medical infrastructure includes water filtration, benching with outlets, emergency showers, eyewash stations, chemical storage, and ISO 7 QC labs. 4233 Technology Drive is positioned at the gateway to the Research Triangle. Duke University and its surrounding medical systems are minutes away, while proximity to Interstate 85 and Highway 501 affords quick access to Chapel Hill, RDU Airport, and Raleigh. This power market provides exceptional talent as the region saw life sciences employment increase by 38% from 2020 through 2025. Beyond convenient commutability, the immediate area is replete with essential retailers, eclectic restaurants, grocery stores, hotels, and multifamily communities, an amenity-rich environment that enhances staff lifestyles. Remedy Medical Properties is a leading owner and operator of outpatient medical real estate, delivering integrated services across investments, development, leasing, management, and strategy. We own and operate medical office properties so healthcare providers can focus on patient care. Remedy Medical Properties specializes in the leasing of medical office space and outpatient medical buildings for physicians, health systems, and medical groups nationwide. Our team works directly with providers to deliver flexible space solutions that support clinical operations, patient access, and long-term growth. Learn more at remedymed.com

Property Type:

Flex

Date on Market:

2025-06-02

Morrisville Office, Flex for Lease - RTP/RDU

Discover a Premier Commercial Opportunity in the Heart of the Raleigh-Durham Triangle! Welcome to 3300 Gateway Center Blvd, a state-of-the-art flex building designed to cater to a wide range of business needs. Whether you're a small office user, a life sciences innovator, or a logistics powerhouse, this property offers unparalleled flexibility, prime location advantages, and top-tier amenities to elevate your operations. With REGUS as a major anchor tenant, this building is the perfect environment to grow and thrive. --- Property Highlights: - Fully Sprinkled Flex Building: Offering the flexibility to configure office and/or flex space combinations to suit your business needs. - Prime Location: Centrally located in the Raleigh-Durham Triangle area, right next to RDU International Airport and off Interstate I-40. - Unique Setup: Flex spaces with access to common dock-high dock doors and wide corridors allow tenants to easily take deliveries directly to their spaces. This feature makes it ideal for warehouse, distribution, manufacturing, and light industrial tenants. - Anchor Tenant: REGUS, a leader in flexible workspace solutions, providing shared office spaces, conference rooms, and break areas. This allows flex tenants to focus on their core operations without worrying about additional office space requirements. --- Available Spaces: Space A: - Small individual offices or multiple office combinations. - Options for conference rooms or small lab spaces. - Highly configurable to meet diverse tenant requirements. Space B: - Versatile flex spaces suitable for a variety of uses including: - Lab space - Research - Distribution - Warehouse - And more. - Customizable to match tenant needs. Space C: - Two smaller flex/office spaces ideal for satellite offices or smaller entities. --- Amenities: - Common dock-high dock door with wide-rated corridors for seamless logistics. - Two large restroom facilities and showers available for all tenants, reducing overhead costs. - REGUS coworking space offering additional office spaces, conference rooms, and a break room. - Proximity to a wide variety of amenities in the surrounding area. --- Strategic Advantages: - Proximity to Tier-1 Universities: - Duke University - University of North Carolina at Chapel Hill - North Carolina State University - Access to a continuous supply of highly skilled workforce. - Zoning: - Zoned ORD (Office/Research and Development): - Supports a wide range of uses including office, institutional, research and development, light manufacturing, and more. - Designed to mitigate adverse impacts when located near residential areas. --- Ideal For: - Small offices - Distribution centers - Warehouses - Research and development (R&D) - Life science users --- Don’t miss this opportunity to secure your space in one of the most sought-after business locations in the Raleigh-Durham area!

Date on Market:

2025-07-20

Morrisville Office for Lease - RTP/RDU

Nestled in a vibrant Raleigh neighborhood, RDU Center I is an exceptional, multi-tenant office building with modern upgrades and convenient accessibility at 3000 RDU Center Drive. This two-story, 60,083-square-foot building comprises renovated lobbies, refreshed restrooms, and a new roof. The property features a two-story atrium entrance with a granite lobby and monumental staircase, along with a 10% core factor. Originally constructed in 1999, the property is situated in the RDU Center and is conveniently located at the intersection of Interstate 40 and Aviation Parkway. Situated on 7.99 acres in the heart of the Triangle, the property is set within a beautiful park-like setting with ample on-site parking at a 5.6/1,000 parking ratio. RDU Center I boasts unparalleled access to the Raleigh-Durham International Airport and Interstate 40, providing easy commutes and travel in and out of town. Strategically positioned at the core of the region’s dynamic life science and technology cluster, the property is in a prime Raleigh locale. Raleigh is notably the #1 IT city in the US after Silicon Valley. It is also home to three research universities, making for a highly educated workforce.

Date on Market:

2023-06-02

Research Triangle Park Office/Medical for Lease - Research Triangle

Located at the intersection of Triangle Drive and NC-54 Highway in Research Triangle Park, North Carolina, this office and lab facility presents a premier opportunity to establish operations at the heart of one of the most innovation-driven corridors of the country. 2 Triangle Drive is a single-story, Class B building spanning approximately 31,000 square feet. Originally constructed in 1977 and extensively renovated in 2001 with a $4.1 million investment, the building features modernized biotech and lab infrastructure, 24-hour access, air conditioning, and prominent signage opportunities. It includes 135 surface parking spaces, making it ideal for tenants requiring both accessibility and specialized space. Adjacent to the property is Triangle 54, a master-planned, Class A office campus developed by The Keith Corporation and Jerico Development, designed to support innovative science and technology companies. This is just one of the numerous hubs in the Research Triangle that can help tenants develop vital professional partnerships. Central placement is another key locational advantage of 2 Triangle Drive, which aids in recruiting from the competitive workforces in Durham, Raleigh, and Chapel Hill. Employees will enjoy seamless commutes off Interstate 40 and proximity to great amenities such as Starbucks, Burn Boot Camp, Food Lion, Boxyard RTP, Brigs Restaurant, Chipotle, high-end multifamily communities, and much more.

Property Type:

Flex

Date on Market:

2025-08-29

Durham Retail for Lease - Research Triangle

Located at 1612 Carpenter Fletcher Road in Durham, this 6,018 SF standalone flex building sits on a 0.904-acre lot in a prime location just 3.5 miles from Research Triangle Park. The property offers a strategic mix of 3,018 SF of finished office/retail space and 3,000 SF of conditioned warehouse space, providing versatility for a variety of business operations. Recently renovated in 2020, the building features modern finishes, efficient layouts, and a roll-up door for easy loading. With convenient access to I-40, Highway 55, and I-540, the site ensures excellent connectivity to the broader Triangle region, including Raleigh-Durham International Airport, Downtown Durham, and Chapel Hill. Zoned GC, the property supports a wide range of permitted uses, including medical, office, retail, and research and development.

Date on Market:

2026-02-04

Durham Flex for Lease - Research Triangle

Part of the TBC Life Sciences Campus located near the intersection of T.W. Alexander Dr. and S. Miami Blvd. • Includes access to the Symmetry Amenity Center, conveniently located across the street. The new facility features a fitness center, collaborative meeting space, coffee lounge, and outdoor gathering space • Convenient to Research Triangle Park, I-40, I-540, and I-885 • Parking ratio: 3.5/1,000

Date on Market:

2024-11-01

Raleigh Flex for Lease - Glenwood/Creedmoor

Brier Creek Location. Multitenant building. The building offers lots of natural light in the office areas and has easy access to RTP, Durham, Chapel Hill, and Raleigh It's located minutes from I-540, Hwy 70, and RDU International Airport, and is near Brier Creek Shopping Center with restaurants, Target, Walmart,

Date on Market:

2026-03-03

Durham Flex for Lease - Research Triangle

Close proximity to the Research Triangle Park and RDU International Airport.

Date on Market:

2025-09-11

Morrisville Coworking for Lease - RTP/RDU

Give Your Business a Boost in Morrisville Base your business in Morrisville, North Carolina, and enjoy flexible office space in an attractive location for offices, light industry, and hotels. Benefit from being located just north of Raleigh, North Carolina’s capital, in this suburb of the greater Raleigh MSA. Commute easily to your workspace using Interstate 40 which is on your doorstep. Welcome visiting clients at Raleigh-Durham International Airport which is under a 10-minute drive away. Whether you’re looking for a long-term home for your business or just a space to get your head down when you’re on the move, you’ll find what you need here. Spark innovation and find new opportunities to connect in this state-of-the-art office space. Bring your ideas to life in the designer workspaces and creative meeting rooms, fully equipped with superfast WiFi. Our friendly team is always on hand and happy to help should you need anything throughout the working day. Feel inspired by the hive of activity surrounding you and take a break after business meetings in our fully stocked kitchens. Relax after work by taking a stroll around one of the many beautiful lakes or parks that is near the office space. Entertain clients with some delicious food at a nearby restaurant.

Property Type:

Flex

Date on Market:

2024-09-20

Morrisville Office/Medical for Lease - RTP/RDU

Explore the epitome of healthcare real estate situated in the heart of the Cary-Morrisville Area, directly on Davis Dr. Our state-of-the-art, 20,020 sqft Class A medical-grade building is a testament to unparalleled sophistication, featuring hospital-grade elevators and HVAC systems that guarantee a premier medical environment. Strategically located along the bustling 6-lane Davis Dr corridor and within a mile of the new upcoming Apple campus, this facility offers unparalleled visibility and accessibility, making it a cornerstone for healthcare excellence in one of Cary's most sought-after regions, adjacent to RTP. Surrounded by a high-density residential area, this building beckons healthcare professionals with its diverse tenant mix, encompassing Urgent Care, Primary Care, Orthopedics, Physical Therapy and other specialized medical services. Embrace the opportunity to join a thriving community of healthcare practitioners in a facility meticulously designed for success. Elevate your practice in a space that not only meets the current standards but also aligns seamlessly with the future of healthcare.

Property Type:

Office

Date on Market:

2025-02-01

Research Triangle Park Flex for Lease - Research Triangle

Longfellow's Via Labs Purpose-Built Class A Lab Building is comprised of 266,480 rentable square feet and is located at the main-on-main RTP intersection of I-40 and Davis Drive with unparalleled visibility from I-40 with over 170,000 VPD. Via Labs at Hub RTP offers a highly walkable environment, offering many features within the campus including a high-end hotel, conference space, retail, 16-acres of green space, bicycle storage, and over 2,300 multifamily units, with full access to all HUB RTP has to offer including the existing Boxyard Retail.

Date on Market:

2023-03-17

Morrisville Flex for Lease - RTP/RDU

Date on Market:

2023-01-27

Durham Flex for Lease - Research Triangle

Date on Market:

2026-01-22

Morrisville Office, Flex for Lease - Research Triangle

Triangle LIFE is a major hub for science companies in North Carolina’s Research Triangle, connecting people, place and purpose in an amenity-rich atmosphere. Triangle LIFE centers around the life sciences and the people devoted to them. It’s a community of scientists in a shared ecosystem of energy and synergy where proximity is key. Everything works together to make working here remarkable. This is North Carolina’s legendary Research Triangle, the intellectual and creative intersection of three top universities. Raleigh Durham International Airport is just minutes away. Centrally located within this dynamic area, Triangle LIFE is a 100-acre oasis for life science companies on the pulse of what’s happening now and with the ability to anticipate what’s next.

Date on Market:

2026-01-21

Morrisville Flex for Lease - RTP/RDU

This Class A life science campus will offer four 160,000 SF mid-rise buildings and combine state-of-the-art lab space with unmatched amenities provided by Elevate, Longfellow’s proprietary tenant experience and hospitality program. Strategically situated in Research Triangle Park with proximity to surrounding lab and office campuses and offers easy access to major thoroughfares, nearby restaurant and retail amenities, and RDU International Airport.

Date on Market:

2021-03-11

Durham Flex for Lease - Research Triangle

Longfellow’s proprietary tenant experience and hospitality program, Elevate, curates events, programming and services exclusively for our tenant partners.

Date on Market:

2021-07-15

Research Triangle Park Flex for Lease - Research Triangle

WORLD-CLASS AGTECH CAMPUS The Alexandria Center®? for AgTech is the country's first and only multi-tenant and amenity-rich greenhouse campus. Positioned in the heart of Research Triangle Park (RTP)—one of the most prominent research and technology hubs in the United States—5 Laboratory Drive and 9 Laboratory Drive offers a prime leasing opportunity for tenants seeking proximity to innovation, talent, and connectivity. Surrounded by leading biotech, pharmaceutical, and tech firms, this address places your business at the center of a dynamic ecosystem that includes over 300 companies and tens of thousands of professionals. The property benefits from immediate access to major thoroughfares, including I-40 and NC-147, providing seamless connectivity to Raleigh, Durham, and Chapel Hill. Raleigh-Durham International Airport is just minutes away, offering convenient national and international travel options. The surrounding area features a mix of corporate campuses, research institutions, and green spaces, creating a balanced environment for productivity and wellness. Ideal for life sciences, R&D, or professional office users, the building is situated in a master-planned park known for its infrastructure, fiber connectivity, and business-friendly environment. Tenants may benefit from state and local incentives, including workforce development programs and tax credits, depending on use and employment impact. Whether you're expanding operations or relocating to a strategic location, 9 Laboratory Drive delivers the visibility, access, and prestige that forward-thinking companies demand.

Date on Market:

2026-01-30

Durham Office for Lease - Downtown Durham

Located in Downtown Durham in walking proximity to lots of restaurants and retail options such as Bull McCabe’s, Dram and Draught, Mateo Bar de Tapas, and more.

Property Type:

Flex

Date on Market:

2025-07-11

Morrisville Office for Lease - Research Triangle

Lab and Office for Sublease. Available lab space includes BSL2 lab with dedicated exhaust and fume hood, adjacent tissue culture suite, gas lines for CO2 and compressed air. Access to freezer farm, autoclave and glasswash. Separate clean room space (unrated). Potential for shared common and office areas; including break room, conference room, restrooms, lab storage, and shipping/receiving. Some furniture available. Fully furnished main laboratories with BSCs available.

Property Type:

Flex

Date on Market:

2024-06-05