49 Life Science Properties for Lease in North Carolina, USA

Research Triangle Park Office/Medical for Lease - Research Triangle

Located at the intersection of Triangle Drive and NC-54 Highway in Research Triangle Park, North Carolina, this office and lab facility presents a premier opportunity to establish operations at the heart of one of the most innovation-driven corridors of the country. 2 Triangle Drive is a single-story, Class B building spanning approximately 31,000 square feet. Originally constructed in 1977 and extensively renovated in 2001 with a $4.1 million investment, the building features modernized biotech and lab infrastructure, 24-hour access, air conditioning, and prominent signage opportunities. It includes 135 surface parking spaces, making it ideal for tenants requiring both accessibility and specialized space. Adjacent to the property is Triangle 54, a master-planned, Class A office campus developed by The Keith Corporation and Jerico Development, designed to support innovative science and technology companies. This is just one of the numerous hubs in the Research Triangle that can help tenants develop vital professional partnerships. Central placement is another key locational advantage of 2 Triangle Drive, which aids in recruiting from the competitive workforces in Durham, Raleigh, and Chapel Hill. Employees will enjoy seamless commutes off Interstate 40 and proximity to great amenities such as Starbucks, Burn Boot Camp, Food Lion, Boxyard RTP, Brigs Restaurant, Chipotle, high-end multifamily communities, and much more.

Property Type:

Flex

Date on Market:

2025-08-29

Durham Office for Lease - Downtown Durham

The property’s prime location ensures exceptional accessibility, with proximity to major thoroughfares such as Interstates 85, 885, and 147, as well as convenient public transit options. Nearby landmarks include Duke University, North Carolina Central University, and the Museum of Life and Science, placing your business at the center of a thriving academic and innovation hub. Downtown Durham’s eclectic mix of dining, retail, and cultural attractions further enhances the appeal, making this an outstanding opportunity for companies looking to elevate their presence in a growing market.

Date on Market:

2025-08-21

Cary Flex for Lease

102 WOODWINDS INDUSTRIAL COURT has 12,000 SF for lease, featuring highly functional flex and R&D space. Industrial zoning accommodates a wide range of uses, including lab, light manufacturing, industrial services, outdoor storage, personal service businesses, office, and veterinary and kennel. Located on over an acre, the property has generous parking and prominent visibility.

Date on Market:

2025-08-05

Morrisville Industrial for Lease - RTP/RDU

74,163 square foot industrial building built in 1990 located off of Pleasant Groove Church Rd.

Date on Market:

2023-10-13

Durham Office/Medical for Lease - North Durham

Well located 2nd generation lab and clean room manufacturing facility with robust infrastructure.

Property Type:

Flex

Date on Market:

2025-06-02

Durham Flex for Lease - Research Triangle

Date on Market:

2025-01-30

Durham Office/Retail, Retail for Lease - Downtown Durham

Date on Market:

2025-11-04

Morrisville Coworking for Lease - RTP/RDU

Give Your Business a Boost in Morrisville Base your business in Morrisville, North Carolina, and enjoy flexible office space in an attractive location for offices, light industry, and hotels. Benefit from being located just north of Raleigh, North Carolina’s capital, in this suburb of the greater Raleigh MSA. Commute easily to your workspace using Interstate 40 which is on your doorstep. Welcome visiting clients at Raleigh-Durham International Airport which is under a 10-minute drive away. Whether you’re looking for a long-term home for your business or just a space to get your head down when you’re on the move, you’ll find what you need here. Spark innovation and find new opportunities to connect in this state-of-the-art office space. Bring your ideas to life in the designer workspaces and creative meeting rooms, fully equipped with superfast WiFi. Our friendly team is always on hand and happy to help should you need anything throughout the working day. Feel inspired by the hive of activity surrounding you and take a break after business meetings in our fully stocked kitchens. Relax after work by taking a stroll around one of the many beautiful lakes or parks that is near the office space. Entertain clients with some delicious food at a nearby restaurant.

Property Type:

Flex

Date on Market:

2024-09-20

Wake Forest Multiple Space Uses for Lease - Route 1

New 30-acre business community located along Star Road (US 1) near South Main Street (New Falls of Neuse Road) Conveniently located near a variety of business amenities, shopping, entertainment and restaurants, as well as a diverse residential area featuring both mature and new communities.

Date on Market:

2024-07-09

Raleigh Medical for Lease - West Raleigh

3-story, 42,331-square-foot medical office building located in the heart of West Raleigh. Part of a seven-building medical park located directly across from UNC Rex Hospital on Lake Boone Trail. This prime West Raleigh location is surrounded by retail and restaurant amenities and is minutes from I-440/I-40, the NC Museum of Art, Lenovo Center and Carter Finley Stadium.

Property Type:

Office

Date on Market:

2025-07-30

Research Triangle Park Flex for Lease - Research Triangle

Longfellow's Via Labs Purpose-Built Class A Lab Building is comprised of 266,480 rentable square feet and is located at the main-on-main RTP intersection of I-40 and Davis Drive with unparalleled visibility from I-40 with over 170,000 VPD. Via Labs at Hub RTP offers a highly walkable environment, offering many features within the campus including a high-end hotel, conference space, retail, 16-acres of green space, bicycle storage, and over 2,300 multifamily units, with full access to all HUB RTP has to offer including the existing Boxyard Retail.

Date on Market:

2023-03-17

Cary Office for Lease

Date on Market:

2023-01-27

Morrisville Flex for Lease - RTP/RDU

Date on Market:

2023-01-27

Raleigh Office/Medical for Lease - Six Forks/Falls of Neuse

• Space planning available • Tenant improvement allowance • Central to all Hospitals: - 4.5 Miles to WakeMed North Hospital - 6.8 Miles northwest of Duke Raleigh Hospital - 7.4 Miles from UNC REX Healthcare Hospital • Ideal for medical treatment suites, surgical practices & other healthcare-related businesses • Within 1 mile of numerous restaurants & retail shops • On-site cafe & state-of-the-art fitness facility with indoor pool, basketball courts & showers • On-site Pharmacy • Lakeside patio • 0.75 miles of walking trails • 4+ spaces per 1,000 SF • Attached covered parking garage • Easily accessible surface parking

Property Type:

Office

Date on Market:

2024-05-21

Durham Flex for Lease - Research Triangle

Date on Market:

2022-05-12

Winston-Salem Office for Lease - Winston-Salem CBD

Located in the South West Corner of the Innovation Quarter, this converted tobacco factory offers hard wood floors, high ceilings and exposed masonry finishes. This building was used for the manufacturing of “Prince Albert Pipe Tobacco” and has now been converted for office, lab, and residential use. The building is predominantly occupied by biotech companies, and features a freight elevator and loading docks. There are a variety of office sizes and layouts available.

Date on Market:

2025-08-25

Durham Office, Flex for Lease - Downtown Durham

203,249 SF Class A mixed use with office and lab space. 200 luxury apartments under construction.

Date on Market:

2025-10-15

Raleigh Office for Lease - West Raleigh

1791 Varsity Drive is located in North Carolina State University’s world-class Centennial Campus, one of Raleigh-Durham’s premier office and research parks. Situated just south of NC State’s main campus and two miles west of Downtown Raleigh, the property benefits from an amenity-rich location just south of NC State’s main campus. Centennial Campus is a 1,314-acre research park owned and operated by NC State. The campus is home to more than 70 corporate, governmental and non-profit “partners,” along with 75 N.C. State research centers, institutes and departmental units and numerous colleges. In addition to the buildings and research centers, Centennial Campus also contains public walkways, a fishing pier and lake, game fields and an 18-hole golf course.

Date on Market:

2024-09-26

Morrisville Flex for Lease - RTP/RDU

This Class A life science campus will offer four 160,000 SF mid-rise buildings and combine state-of-the-art lab space with unmatched amenities provided by Elevate, Longfellow’s proprietary tenant experience and hospitality program. Strategically situated in Research Triangle Park with proximity to surrounding lab and office campuses and offers easy access to major thoroughfares, nearby restaurant and retail amenities, and RDU International Airport.

Date on Market:

2021-03-11

Durham Office for Lease - Research Triangle

Patriot Science Center is a life science facility with second generation lab, vivarium and office space previously occupied by Pfizer, Laird, and Argos. Building systems are separated by suite.

Property Type:

Flex

Date on Market:

2020-06-15

Durham Flex for Lease - Research Triangle

Longfellow’s proprietary tenant experience and hospitality program, Elevate, curates events, programming and services exclusively for our tenant partners.

Date on Market:

2021-07-15

Holly Springs Land for Lease - Southwest Wake County

Raw, level land located in the heart of Holly Springs, NC. Property is at a signalized intersection and boasts over 1,000 feet of frontage on Avent Ferry Road.

Property Subtype:

Commercial

Date on Market:

2025-09-04

Durham Office for Lease - Downtown Durham

Located in Downtown Durham in walking proximity to lots of restaurants and retail options such as Bull McCabe’s, Dram and Draught, Mateo Bar de Tapas, and more.

Property Type:

Flex

Date on Market:

2025-07-11

Durham Flex for Lease - Research Triangle

Date on Market:

2025-06-02