19 Life Science Properties for Lease in New York, NY, USA

New York Office for Lease - Columbus Circle

525 W 57th Street is a future-forward professional office and lab building on Manhattan's West Side. The 500,000-square-foot building rises 10 floors and boasts the substantial characteristics and infrastructure to support tenant growth and creativity. Property features include M1-5 zoning for office, life science, and light manufacturing use, floors with a live load capacity of 120 pounds per square foot, immersive 12-foot, 1-inch to 15-foot, 10-inch ceiling heights, natural light-filled interiors from large windows, and more. Tenants and guests have access to three lobbies (two on 57th Street and one on 58th Street). The two lobbies on 57th Street were recently renovated. One of the lobbies was designed by Dan Shannon and MdeAS and features a frieze art sculpture by Stephen Doyle. Open and efficient side-core floor plates allow flexibility for layout and design. Full and partial floors are immediately available for occupancy and can be customized to meet business needs. Situated within walking distance of Columbus Circle, 525 West 57th Street is surrounded by the city's finest dining and entertainment. 521 W 57th Street tenants enjoy zero initiation fees and reduced membership rates to the Mercedes Club, a luxury all-inclusive gym and health club conveniently located at 550 West 54th Street. Mass transit users benefit from convenient access to the 59th Street – Columbus Circle Subway station for hassle-free commuting to and from the property. Surrounding amenities like Hudson Market, Lincoln Center, Central Park, and the Shops at Columbus Circle are accessible within moments.

Date on Market:

2023-01-10

Jamaica Industrial for Lease - South Queens

The Ideal Industrial Building is located at 184-10 and 184-60 Jamaica Avenue in Jamaica, Queens. The property, totaling 618,222 square feet, consists of two interconnected 5- and 6-story industrial buildings situated on a 152,100-square-foot lot. The building has 490 feet of frontage along Jamaica Avenue and is flanked by a 30,000-square-foot parking lot with 127 spaces. The first floor is best suited for distribution/logistics with high ceilings and drive-in doors. With additional availabilities on the upper and lower levels for manufacturing and R&D, The Ideal Industrial Building offers a large contiguous block across these three floors. Queens Logistics Center is ideally situated along Jamaica Avenue, the area’s major thoroughfare, and is accessible to I-295, I-678, and I-495. In addition, John F. Kennedy International Airport, LaGuardia Airport, and Manhattan are all accessible within a 30-minute drive. For a convenient commute, employees enjoy proximity to Jamaica Station, serviced by the E, J, M, and Z subway lines and the Long Island Railroad.

Date on Market:

2025-10-28

New York Office for Lease - Hudson Square

96 Morton Street is a professional office building in the heart of Lower Manhattan’s Hudson Square neighborhood. Situated at the southeast corner of Morton and Washington Streets, the nine-story, 125,185-square-foot property is within steps of SoHo, Tribeca, the West Village Greenwich Village, and the Meatpacking District. Building features include 24-hour access, a high-end attended lobby with marble finishes, and a natural light-inviting expansive window line. Secure a place among a thriving creative community with a diverse tenant mix. The entire fourth floor is immediately available for lease in white-boxed condition. This build-to-suit space offers 12-foot exposed ceilings, three sides of windows, and an efficient floor plan with ample room for a reception area, conference rooms, individual workstations, and private offices. Permitted uses, strong performance standards, and strategic locations position M1-5 districts as a strong choice for modern manufacturing in New York. With multiple floors available, 96 Morton Street's M1-5 designation offers exceptional opportunities for light manufacturing, research and development, laboratories, creative production, and high-tech operations. Fully enclosed spaces comply with city performance standards, making the property ideal for businesses seeking a controlled, efficient, and adaptable environment for innovation and production. 96 Morton Street sits on a fantastic tree-lined street close to the West Side Promenade and the Hudson River Greenway, surrounded by numerous dining, fitness, and service businesses. Pier 40 at Hudson River Park and views of the Hudson River and New Jersey are only a short distance away. Plus, capitalize on efficient commutes via convenient PATH Train and 1, C, and E subway line access.

Date on Market:

2022-10-20

New York Office for Lease - Plaza District

Situated along a prestigious stretch in the heart of the Plaza District, 345 Park Avenue provides a world-class identity for tenants. The 44-story building occupies an entire city block between Park and Lexington Avenues and East 51st and 52nd Streets, with exceptional views of Central Park and the East River. The recently completed lobby, designed by Skidmore, Owings & Merrill in 2021, features new escalators connecting the Park and Lexington levels, sleek touchless entry turnstiles, destination dispatch elevators, and enhanced lighting. As a WiredScore Certified Platinum building, 345 Park Avenue offers state-of-the-art internet infrastructure, ensuring top-tier digital connectivity and technological readiness. There's also a 22,000-square-foot plaza at the base of the building. Large, center-core floor plates ranging from 36,000 to over 70,000 square feet are available for occupancy. Tenants benefit from a portfolio of thoughtfully curated amenities designed to provide an exceptional employee experience. The Lexington and Park Avenue levels feature collaborative spaces, diverse culinary options from fine dining to a food hall, a health and wellness facility, and a modern fitness center. Additional amenities include a parking garage, bike storage, and a newsstand. An all-day dining and meeting space is also planned, which is ideal for breakfast or lunch meetings, after-work entertainment, and large corporate events. 345 Park Avenue is surrounded by many celebrated points of interest, such as the Racquet & Tennis Club, Jean-Georges Restaurant, and the Waldorf-Astoria New York, along with dozens of other key amenities. Multiple transit hubs are less than a 10-minute walk away, including Grand Central Terminal, which connects to the Metro-North Railroad, the Long Island Rail Road, and several subway lines. 345 Park Avenue delivers an extraordinary leasing opportunity for tenants seeking a prestigious, well-connected Midtown Manhattan address.

Date on Market:

2024-07-29

New York Office/Medical for Lease - Gramercy Park

Centrally located in the Midtown Southeast Submarket of New York City, 380 Second Avenue has become a highly desired address for departments of leading medical and educational institutions in the surrounding area. Tenants include New York University’s Department of Physical Therapy and College of Dentistry, NYU Langone Hospital’s Diagnostic Imaging Center and Hospital for Joint Diseases, Mt. Sinai’s New York Eye & Ear Infirmary, and the School of Visual Arts, to name a few. The building was recently branded The Gramercy Medical Arts Building due to its mix of world-renowned tenants in the fields of healthcare, the arts, and education. 380 Second Avenue stands 10 stories tall, consisting of 20,000 rentable square feet for a total of 182,258 square feet. The property features 300-pound floor loads, two handicapped accessible lobbies, and a private loading dock on 22nd Street. Each floor benefits from natural light, with the top three floors showcasing excellent views of the NYC skyline. The available medical suites at Gramercy Medical Arts Building provides flexible options, both on the building’s top floor. Suite 1002 spans a total of 1,334 square feet of move-in-ready space, complete with a consultation room, three exam rooms with sinks and built-in cabinetry, a lab room, a reception/waiting area, and private restrooms. Suite 1003 comprises 2,432 square feet and has a flexible build-out that includes a reception area, two consultation rooms, four exam rooms with built-in exam tables and cabinetry, a wet pantry, and a storage room. Both suites are equipped with premium finishes such as hardwood flooring, attractive lighting fixtures, quality built-ins, and sweeping views of the city skyline through oversized, operable windows. The spaces permit use as outpatient surgery or ambulatory surgery centers, facilitated by access to a sit-up gurney-sized elevator. Its prime, central location in Medical/Education Alley provides a premier environment for medical tenants. The building is situated in a convenient proximity to leading Midtown Southeast hospitals, providing frequent opportunities for partnership and synergy. A large number of nearby higher education institutions also deliver tenants access to a valuable, skilled workforce. More than 105,000 daytime employees work in Education and Health Services fields within 1 mile of the property, providing an endless supply of highly qualified new talent to promote continued growth and expansion for local medical tenants. Don’t miss this chance to claim a top spot at the heart of New York City’s Medical and Higher Education systems with the best-in-class, move-in-ready spaces at Gramercy Medical Arts Building. Reach out to the ABS Partners Real Estate team today to schedule a tour and learn more about this rare opportunity.

Property Type:

Office

Date on Market:

2025-06-13

New York Office for Lease - Times Square

Built in 2020, 603 W 44TH ST (also known as 589 11th ave) offers two boutique full-floor office suites (2,630 RSF each) with modern systems and on-site fine dining and rooftop amenities. Ideal for executives or creative firms seeking a private HQ near Hudson Yards and Javits. ONLY TWO FULL FLOORS AVAILABLE – BRAND-NEW CONSTRUCTION (2020) – PRIVATE (24HR) ENTRY & ROOFTOP ACCESS Experience Manhattan’s West Side from a newly constructed boutique office property totaling 17,000 SF. Each 2,630 RSF floor is delivered in white-box condition with modern mechanicals, private restroom, and flexible layouts for custom build-outs. Landlord is open to turnkey delivery for qualified tenants. 589 Eleventh Avenue combines executive-level workspace and hospitality in one address – featuring a ground-floor Michelin-quality restaurant (Era New York) and a rooftop restaurant & lounge with panoramic views of Hudson Yards and the Midtown skyline. Highlights • New construction (2020) – energy-efficient systems & modern infrastructure • Two 2,630 RSF full floors available – each with private identity and 24/7 access • Smart access control (Brivo) and elevator serviced • On-site fine dining & rooftop lounge amenities • Landlord build-out / TI packages available • Ideal for executive offices, creative firms, agencies, or family offices • Walking distance to Hudson Yards, Javits Center, and residential towers (Sky & Silver Towers) 5-minute walk to Port Authority / subway lines Keyworkds: Hudson Yards office space, Hell’s Kitchen office for lease, Midtown West executive office, boutique Class B office, new construction 2020 office, private full-floor lease, rooftop office space NYC, Hudson Yards creative space, 589 Eleventh Avenue office, 603 w 44th st for lease, Hudson Yards office space for lease, Midtown West creative office, Javits Center proximity office, Boutique full-floor office Manhattan, Flexible size 500-7,890 SF,

Date on Market:

2024-04-04

Maspeth Industrial for Lease - Central Queens

Now available for lease at $30 PSF NNN, 48-23 55th Avenue delivers a ready-to-occupy flex warehouse solution in one of NYC’s most connected industrial zones. This single-story facility offers ±18,800 SF of warehouse space, ±11,600 SF of lab space, and ±4,500 SF of office space, ideal for logistics, light manufacturing, or specialized medical operations. The property’s previous use as a sterile IV infusion lab means it includes unique infrastructure that can be retained or retrofitted for general industrial use. Tenants benefit from two oversized interior loading docks, 16’ clear height, and 18 dedicated parking spaces. The site’s proximity to the BQE and LIE interchange ensures efficient distribution across the Tri-State area, while nearby access to JFK, LaGuardia, and Newark airports supports regional and national logistics. Surrounded by high-credit tenants such as FedEx, UPS, and Tesla, this location offers both prestige and performance. Recent renovations, including a new roof and upgraded systems, make this a plug-and-play solution for industrial users seeking speed-to-market.

Date on Market:

2025-10-09

Maspeth Office for Lease - Central Queens

Citizens Bank currently operating on ground floor level. Lower level/Basement. Spacious, high ceilings, private entrance with elevator. Open BIG SPACE

Date on Market:

2025-06-25

Jamaica Industrial for Lease - South Queens

ReadySpaces Queens Jamaica at 184-10 Jamaica Avenue is a community of businesses with individual warehouse, storage, and office spaces under one roof. Join a vibrant collection of small businesses with all-inclusive pricing and no hidden fees. ReadySpaces Queens Jamaica offers flexible lease terms, including short-term, and the ability to grow or reduce your space. Brokers, there's no fuss involved—just make a call and receive a market commission if your client signs a lease. You don't have to show up—we'll handle the tour. Immediately available, secure warehouse/storage spaces range from 250 to 5,000 square feet, with power (120V, 240V, 208V—varies), free Wi-Fi, and access to loading docks and drive-in doors for every unit. Office spaces range from 110 to 300 square feet. There is 24/7 building access, CCTV monitoring, and a security system. Tenants also have free access to conference rooms, kitchens, common spaces, pallet jacks, and other equipment. Ideally situated along Jamaica Avenue, the area's major thoroughfare, and is accessible to Interstates 295, 678, and 495. In addition, John F. Kennedy International Airport, LaGuardia Airport, and Manhattan are all accessible within a 30-minute drive. For a convenient commute, employees enjoy proximity to Jamaica Station, which is serviced by the E, J, M, and Z subway lines and the Long Island Railroad.

Date on Market:

2024-05-15

Brooklyn Office/Medical for Lease - South Brooklyn

Easy access to major roadways and metro lines.

Property Type:

Office

Date on Market:

2024-03-21

Forest Hills Office/Medical for Lease - Central Queens

Prime Offices space for lease in the most busiest hub of Austin Street located next to Major national stores and Restaurants such as Target, Eddie Baur, GAP, Starbucks, TGIF and more... This store is located just two blocks off Continental Ave and Queens Blvd with only two blocks to subways, and LIRR. This space is ideal for and is currently used as a long time established MD office however, other office use is possible as well. Austin street is known for its strip of many popular retail businesses, restaurants, gyms and more..

Property Type:

Retail

Date on Market:

2025-05-19

Long Island City Office for Lease - Northwest Queens

Prime Commercial Property in Long Island City – Fully Built-Out & Move-In Ready Seize this rare opportunity to secure a fully built-out commercial property in the heart of Long Island City. This recently renovated office and industrial building offers a turnkey solution for businesses seeking a modern, dynamic, and move-in-ready space. With over $1.5 million invested in upgrades, the property features state-of-the-art amenities, security systems, and minimal capital investment requirements—allowing businesses to operate from day one. Key Highlights: • Exceptional Location: Just minutes from the waterfront and one block from the Queensboro Bridge onramp, offering direct access to Manhattan. • Unmatched Accessibility: A short 5-minute walk to Court Square and Queensboro Plaza subway stations, ensuring seamless commutes for employees and clients. • High Visibility: Dual street frontage totaling 150+ feet, maximizing exposure and accessibility. • Turnkey & Secure: The office space is fully built-out and includes an advanced security and access control system, providing a seamless transition for new occupants. Property Details: • Total Building Size: 10,000 sq. ft. across three floors. • Additional Parking Space: 6,000 sq. ft. dedicated lot. • Freight Elevator: Services all three floors for convenient loading and transport. • Dedicated Loading Area: Ensures efficient operations for businesses with logistical needs. Interior Layout: • Lower Level (Cellar): 2,500 sq. ft. of well-designed office space. • First Floor: 2,750 sq. ft. featuring a conference room and separate vestibule. • Second Floor: 2,250 sq. ft. of private offices, ready for immediate use. • Warehouse Space: 2,500 sq. ft. of flexible industrial, office, or retail space featuring a private driveway, central HVAC, and abundant natural light. Adjacent to the Cellar, offering a total of 5,000 sq. ft. of contiguous single-floor space. Parking & Outdoor Features: • Corner Parking Lot: A rare asset in the area, offering 106 ft of frontage on 43rd Ave and 49 ft on the adjacent street—ideal for employees, clients, or fleet vehicles. This high-profile property blends prime location, modern renovations, advanced security, and immediate usability, making it a cost-effective, move-in-ready option for businesses looking to establish a presence in one of NYC’s fastest-growing districts. Schedule a tour today to experience the potential of this exceptional space!

Date on Market:

2025-02-27

Long Island City Office for Lease - Northwest Queens

Date on Market:

2025-06-17

Long Island City Flex for Lease - Northwest Queens

This property was built in 1931 and is zoned M1.

Property Type:

Office

Date on Market:

2025-04-29

New York Office, Office/Medical for Lease - Columbus Circle

The Hudson Research Center is a hub for life sciences and medical office space on the west side of Manhattan. The building has some of the only pre-built life science wet lab spaces available for immediate occupancy in the city and is located within a dense cluster of research institutions.

Date on Market:

2025-02-13

Ridgewood Flex for Lease - Central Queens

NEW, STATE-OF-THE-ART, GROUND-UP CONSTRUCTION DESIGNED TO SUPPORT YOUR BUSINESS. FROM OPERATIONAL AGILITY TO TRANSPORTATION LOGISTICS, THE FILM FACTORY HAS YOU COVERED. - Mixed use Community with 200 + Car Parking - Office/Flex, Retail, industrial and production studio opportunities - Fourth floor outdoor terrace, outdoor decks and Roof-top Dining along with roof-top vehicle storage. - Freight load-in, vehichle elevators

Date on Market:

2025-08-26

Far Rockaway Office for Lease - South Queens

Wavecrest Gardens is a beautifully landscaped, gated community adjacent to Rockaway Beach. The multibuilding complex features blossoming greenery and waterfront breezes. Fully built-out medical office suites are available for immediate occupancy. These units include efficient layouts with reception and waiting areas, office and exam rooms, lab space, rooms for filing and storage, and more. Lease terms are negotiable. Linking the borough of Queens to Long Island, Far Rockaway is an oceanfront community with a unique blend of boardwalk-lined properties, historic Art Deco bungalows, and larger apartment buildings. People can access the neighborhood with a quick 45-minute commute from Manhattan on the A train.

Property Type:

Multifamily

Date on Market:

2024-07-22

New York Office, Retail for Lease - Hudson Square

180 Varick Street offers a stunning Class-B office tower with a prime location at the gateway between Manhattans West Village and SoHo neighborhoods. Spanning 329,11 square feet across 17 stories, 180 Varick Street was built in 1929 and completed a full renovation in 2005. The building’s attractive art deco façade and entryway makes a notable statement that brings robust attention to the historic property. Tenants of the building enjoy access to quality amenities, including 24-hour secure access, on-site property management, five high-speed passenger elevators, and more. Capping the block where King and Charlon Streets meet Varick Street, the building is strategically placed near many of the area’s top amenities and recreation opportunities. Tenants can easily walk to several nearby national retailers, including Chipotle, Chopt, CAVA, Dunkin’, McDonald’s, and Shake Shack, as well as many popular local restaurants. The surrounding area also offers some of the city’s best outdoor spaces, with the Hudson River Park and James J Walker Park reachable in walking distance. The desirability of the area has made it a hot spot for corporate activity, including the nearby NYC HQ for Google with over 14,000 employees.

Date on Market:

2025-11-03

Jamaica Industrial for Lease - South Queens

Date on Market:

2025-10-17