35 Life Science Properties for Lease in New York, USA

New York Office for Lease - Columbus Circle

525 W 57th Street is a future-forward professional office and lab building on Manhattan's West Side. The 500,000-square-foot building rises 10 floors and boasts the substantial characteristics and infrastructure to support tenant growth and creativity. Property features include M1-5 zoning for office, life science, and light manufacturing use, floors with a live load capacity of 120 pounds per square foot, immersive 12-foot, 1-inch to 15-foot, 10-inch ceiling heights, natural light-filled interiors from large windows, and more. Tenants and guests have access to three lobbies (two on 57th Street and one on 58th Street). The two lobbies on 57th Street were recently renovated. One of the lobbies was designed by Dan Shannon and MdeAS and features a frieze art sculpture by Stephen Doyle. Open and efficient side-core floor plates allow flexibility for layout and design. Full and partial floors are immediately available for occupancy and can be customized to meet business needs. Situated within walking distance of Columbus Circle, 525 West 57th Street is surrounded by the city's finest dining and entertainment. 521 W 57th Street tenants enjoy zero initiation fees and reduced membership rates to the Mercedes Club, a luxury all-inclusive gym and health club conveniently located at 550 West 54th Street. Mass transit users benefit from convenient access to the 59th Street – Columbus Circle Subway station for hassle-free commuting to and from the property. Surrounding amenities like Hudson Market, Lincoln Center, Central Park, and the Shops at Columbus Circle are accessible within moments.

Date on Market:

2026-04-24

Pearl River Multiple Space Uses for Lease - Orangetown

Hudson Valley iCampus is a 207-acre mixed-use campus at 401 N Middletown Road in Pearl River, New York. Hudson Valley iCampus offers highly sought-after laboratory, office, and GMP (Good Manufacturing Practice) space in a campus setting built to support growth. Designed for both emerging companies and established industry leaders, the facility gives tenants access to specialized, move-in-ready space without the time and expense of ground-up development. A major advantage is the on-site 23-megawatt Central Utility Plant, which provides reliable, cost-effective electricity, steam, and chilled water, backed by redundant public systems. With a prestigious roster of tenants that includes Pfizer, Sanofi, Momentive Performance Materials, Olaplex, RK Pharma, and others, the campus delivers a strong business environment shaped by innovation, proven infrastructure, and long-term credibility. With a legacy of groundbreaking vaccine development and a reputation as one of the top destinations in the New York tri-state area for life sciences, biotech, and manufacturing and warehouse users, Hudson Valley iCampus stands out as a compelling choice for companies seeking room to operate and grow. Hudson Valley iCampus is strategically positioned in the Hudson Valley, offering businesses convenient access to dining, shopping, hotels, and entertainment, along with strong regional connectivity. Located within 24 miles of Manhattan, the campus provides easy access to train stations, the Mario M. Cuomo Bridge, and the New York State Thruway, making it highly accessible for employees, clients, and operations. Situated within the heart of a growing biotech megaregion, the property gives tenants direct access to a highly skilled labor pool and proximity to other major life science hubs. Its location near Downtown Pearl River and the retail, dining, and hospitality options in Nanuet further enhance the appeal for companies seeking both convenience and a well-connected business environment.

Date on Market:

2026-04-21

Troy Office for Lease - Downtown Troy

The Gurley Building, located at 514 Fulton Street, is a landmark property in Troy, New York. Formerly used for engineering, research, and development, the four-story professional building contains 57,900 square feet and is listed on the National Registry of Historic Places. A stunning interior atrium courtyard, high exposed ceilings, grand arched windows overlooking inspiring city views, and plank wood floors add unparalleled charm and nod to the property’s industrial past. Tenants also benefit from secure intercom front entry, reliable and on-site property management, and access to ample off-street parking in adjacent lots. The second, third, and fourth floors are available for lease and is sub-dividable with flexible options for complimentary custom space planning. Experience an open floor plan loft with over 12 private offices, conference rooms, and richly textured brick walls. This space is ideal for creative thinkers and professional businesses. Situated in the heart of Downtown Troy, the Gurley Building is within walking distance of restaurants, hotels, shops and trendy boutiques, and many other local amenities. Reach the campuses of Rensselaer Polytechnic Institute (RPI) and Russell Sage College within minutes and enjoy easy access to all major highways: I-87, I-90, and I-787. The Gurley Building is a perfect destination for all creative professionals!

Date on Market:

2026-04-03

Albany Office, Office/Medical for Lease - E Outer Albany County

Computer Park, located just off Wolf Road in Colonie, New York, offers executive and professional office space ranging from 258 to 3,305 square feet within a thoughtfully designed 11-building office campus. From sleek executive suites to expansive full-floor layouts, the property delivers flexible configurations that accommodate solo entrepreneurs, growing teams, and established businesses. All offices enjoy bright interiors with ample natural light, while select suites offer private mailboxes, storage options, shared or private conference rooms, kitchenettes, waiting areas, skylights, and French glass doors. All-inclusive leasing packages include parking, property maintenance, taxes, snow removal, common area maintenance, and basic janitorial services, with utilities also available for inclusion. Supported by on-site professional management and 24/7 secure access, Computer Park presents a turnkey solution that allows businesses to focus on productivity and growth in a prestigious, park-like setting. Professionally maintained year-round, Computer Park blends function and curb appeal through landscaped grounds that create a welcoming environment for employees and visitors. Furnished and unfurnished suites, customizable layouts, and a wide range of floor plans support diverse work styles, from client-facing professional services to collaborative office users. A 70-space parking lot, on-campus EV charging stations, immediate access to the Albany bus line, and responsive on-site management enhance daily convenience and operational efficiency. Situated minutes from Interstates 87 and 90, Computer Park delivers seamless regional connectivity via the Northway, providing quick drives to Downtown Albany, Troy, Schenectady, and Saratoga Springs, as well as a short commute to Albany International Airport. The Wolf Road corridor anchors one of the Capital Region’s strongest commercial districts, surrounded by prominent retailers and dining options, including Outback Steakhouse, LongHorn Steakhouse, Ruth’s Chris Steak House, Nothing Bundt Cakes, McDonald’s, Chipotle, and many more within a half-mile. Computer Park is a prime opportunity to lease flexible, professionally managed office space designed to support long-term business success in a thriving market.

Date on Market:

2026-05-13

Orangeburg Office, Industrial for Lease - Orangetown

Position your business in one of Orangeburg’s most versatile and strategically located commercial properties. 560 Route 303 offers modern, flexible office space ranging from 1,000 SF to 20,000 SF, ideal for professional offices, creative teams, technology firms, medical users, administrative headquarters, and growing businesses seeking a highly accessible Rockland County location. The property features an abundance of natural light throughout the office spaces, creating a bright and productive work environment for employees and clients alike. The building is home to several established corporate companies, providing tenants with a professional and business-oriented atmosphere. The property currently underwent upgrades and improvements, creating a refreshed and modern environment for tenants. Spaces can be customized to accommodate a variety of layouts, from private executive offices and collaborative open workspaces to conference rooms and client-facing operations. For companies that require both office and industrial functionality. In addition to the office availability, the property also offers industrial and warehouse space options. Conveniently located directly on Route 303 with immediate access to the Palisades Parkway, I-87, I-287, and the New Jersey border, the property offers excellent regional connectivity for employees, clients, and commuters.

Date on Market:

2026-05-18

Orangeburg Flex, Industrial for Lease - Orangetown

Date on Market:

2026-05-15

Buffalo Office/Medical for Lease - Buffalo CBD

Property Type:

Office

Date on Market:

2026-01-14

Buffalo Office, Flex for Lease - North

Date on Market:

2025-12-02

Chester Retail for Lease - Monroe

Discover this well-maintained 24/7 full-access Class B commercial building, perfectly blending functional lab space with modern executive offices. The main floor is primarily dedicated to lab space, including a critical clean room. Adjacent to the clean room, you'll find an unfinished/industrial-style area with open ceilings, ideal for specialized operations, complemented by a convenient small loading dock. Upstairs, the executive office space provides a professional environment. The full finished basement adds significant utility with a break room, multiple offices, and a hallway with lockers, offering ample support and storage. Traffic counts around the property are: 12,814 AADT on Brookside Ave. and 51,097 on NY-17 - Exit / Entrance ramps are around the corner - Very easy access to the highway Offered on a Triple Net lease basis, tenant pays rent and all operating expenses. Listing may not itemize all expenses.

Date on Market:

2025-07-15

Victor Office, Flex for Lease - Southeast

Premier Office, Flex & Development Opportunities at Omnitech Business Park Located within the highly regarded Omnitech Business Park, Omnitech Place offers exceptional leasing opportunities for office, flex, and light industrial users seeking a professional business environment with outstanding regional accessibility. Positioned with convenient access from Phillips Road, the park provides easy access for employees, clients, and deliveries while benefiting from Victor's continued commercial growth. The business park features attractive curb appeal, mature landscaping, abundant parking, and flexible floor plans designed to accommodate a wide variety of business operations. Whether you're seeking move-in-ready office space, office/flex configurations, warehouse space with loading, or a future build-to-suit opportunity, Omnitech Business Park offers scalable solutions for companies of all sizes. Located just minutes from Route 96, Interstate 490, and the New York State Thruway (I-90), the park provides exceptional connectivity throughout the Rochester region while placing tenants in one of Victor's premier commercial campuses. Available Space 7620 Omnitech Drive 12,188 SF Office Suite Move-in-ready office suite featuring private offices, conference rooms, open work areas, break room, and support spaces. Ideal for corporate headquarters, technology, engineering, healthcare, or professional service firms. 17,426 SF Office/Flex Suite Functional office and warehouse space featuring a loading dock, making it ideal for light manufacturing, distribution, contractors, service companies, laboratory, or flex users. 29,614 SF Contiguous Opportunity The 12,188 SF and 17,426 SF suites are adjacent and may be combined to create up to 29,614 SF of contiguous office/flex space for larger users. 7615 Omnitech Place 9,216 SF End Suite Highly functional end-cap office/flex suite featuring its own loading dock, excellent natural light, and a flexible layout well suited for office, showroom, warehouse, or light industrial operations. 7675 Omnitech Place 2,432 SF Move-In Ready Office/Flex Suite Efficient office/flex suite featuring a modern office build-out with immediate access to a loading dock located directly behind the suite. A double-door entrance is situated just steps (approximately 10 feet) from the dock, providing exceptional convenience for receiving, shipping, product storage, or light industrial operations. Property Highlights Multiple office, flex, and light industrial suite options ranging from 2,432 SF to 29,614 SF Contiguous space available up to 29,614 SF Multiple suites with loading docks Move-in-ready office and office/flex opportunities Flexible floor plans for office, medical, technology, engineering, manufacturing, distribution, contractors, and service users Professional business park environment with established corporate and industrial tenants Attractive landscaping and excellent curb appeal Ample on-site parking Excellent access to Route 96, Interstate 490, and the New York State Thruway (I-90) Located in Victor, one of the Rochester area's fastest-growing commercial markets Future Development Opportunity Omnitech Business Park also offers more than 22 acres of development land with significant expansion potential. The site can accommodate up to four additional buildings or a custom build-to-suit facility ranging from approximately 30,000 SF to 150,000 SF, subject to Town approvals. This provides businesses with the opportunity to establish an immediate presence while maintaining the flexibility to expand within one of the Rochester region's premier office, flex, and industrial business parks.

Date on Market:

2026-07-17

Islandia Industrial for Lease - Western Suffolk

3100-3124 Express Drive South is a 36,000 SF commercial multi-tenant building located directly on the LIE Southern Service Road and Exit 57 and Veterans Memorial Highway. The location has direct frontage from the Service road and partial LIE visibility. The building is fully landscaped and well maintained with a sister building sitting just South on the site. 3100 Express drive South is located on the edge of the village of Islandia - the intersection of Veterans Memorial Highway and the Long Island Expressway. This location allows for simplified trucking and commuting with proximity to Long Island's major highways (East-West) and Vets highway running Northwest- Southeast.

Date on Market:

2026-06-22

Great Neck Office/Medical for Lease - Western Nassau

Private suites available in a three story, ideal commercial property. It has recently undergone remodeling and renovation, such as New Boiler, Roof, hallways with New paint, Carpet and LED Lighting. Ensuring a comfortable and efficient space for tenants. For additional tenants’ convenience, it also features private bathrooms for all suite, parking spot and elevator. Situated in the heart of Great Neck Plaza,it is highly desirable due to its close proximity to town shopping, banks, post offices, restaurants, parks and LIRR (20 min. Ride to Manhattan) making it an popular spot for any kind of business.

Property Type:

Office

Date on Market:

2025-12-02

Forest Hills Office/Medical for Lease - Central Queens

Prime Offices space for lease in the most busiest hub of Austin Street located next to Major national stores and Restaurants such as Target, Eddie Baur, GAP, Starbucks, TGIF and more... This store is located just two blocks off Continental Ave and Queens Blvd with only two blocks to subways, and LIRR. This space is ideal for and is currently used as a long time established MD office however, other office use is possible as well. Austin street is known for its strip of many popular retail businesses, restaurants, gyms and more..

Property Type:

Retail

Date on Market:

2025-05-19

Port Chester Flex for Lease - East I-287 Corridor

3rd Floor Loft Space - Open Floor Plan Multi use flex space - ideal for R & D, office, assembly, studio and/or production, light storage, wellness space, low impact recreational use, small scale fabrication, . No residential or food. Metro North RR across the street from the building. Bus service directly in front of the building Located in the heart of the Central Business District. Dining and entertainment center. Available immediately Light freight elevator to the premises space.

Property Type:

Office

Date on Market:

2026-04-21

Woodbury Office for Lease - Eastern Nassau

All utilities are separately metered. This office is located in a park-like setting. There is no Loss Factor. The LIE, RTE 135, Northern State Parkway, & Jericho Turnpike are close by. The space is in move in condition, and furniture is available.

Date on Market:

2021-07-14

Menands Office for Lease - E Outer Albany County

Riverview Innovation Center is a 977,780 SF property that has undergone significant renovations to offer a dynamic blend of office and industrial space. Featuring modern finishes, thoughtfully designed common areas, and premium amenities, the building delivers a workplace environment that enhances productivity and collaboration. With flexible spaces available across eight floors, suites of varying sizes can accommodate a range of business needs and are supported by competitive tenant improvement packages, allowing for customized, build-to-suit solutions. Ideally located with excellent accessibility to Downtown Albany, this property is the perfect setting for businesses seeking a modern, versatile, and strategically positioned workplace.

Date on Market:

2024-12-13

Brewster Village Office, Office/Medical for Lease - Brewster

Date on Market:

2026-01-13

Jamestown Office for Lease

The West Gate Building is centrally located in Jamestown’s business district. Condé Nast Traveler has called “one of the best museums in the country” and which attracts 100,000 people a year, and a five minute walk to the Northwest Ice Arena which draws 250,000 people a year. The West Gate Building is the only office building in the downtown business district with ample onsite parking (all of which is unmetered), and is an ideal location for doing business in Jamestown.

Date on Market:

2026-02-01

New York Office/Medical for Lease - Upper East Side

Positioned in the heart of Manhattan’s Upper East Side, 210 East 86th Street is a premier medical and professional office building offering an exceptional leasing opportunity for healthcare providers, institutional medical groups, non-profit organizations, and other qualified tenants. The building features a variety of contiguous and divisible spaces, accommodating practices from approximately 2,000 –44,000 rentable square feet, with the ability to accommodate full-floor users. Designed to support the evolving needs of today’s healthcare professionals, the property offers a combination of move-in-ready medical suites, second-generation laboratory space, professional office installations, and raw space for fully customized build-outs. Efficient floor plates allow tenants to establish new practices, expand existing operations, or consolidate multiple locations within a single, highly accessible building. Current availabilities include a former LabCorp facility, multiple general medical suites, full-floor opportunities, and raw space suitable for custom medical installations. 210 East 86th Street provides the flexibility, infrastructure, and prestigious Upper East Side location to support a wide range of medical and professional uses. The building is situated just one block from the 86th Street Station, providing access to the Q, N, and R subway lines, with direct connections to Midtown Manhattan, Times Square, Herald Square, Lower Manhattan, and Brooklyn. The 4, 5, and 6 subway lines at 86th Street and Lexington Avenue are just over one block from the property, offering convenient north-south service throughout Manhattan and connections to the Bronx. The property is additionally served by numerous MTA bus routes, including the M86 Select Bus Service (crosstown), M15 Select Bus Service along Second Avenue, and the M101, M102, and M103 routes along Third and Lexington Avenues, providing outstanding public transportation options from all areas of Manhattan.

Property Type:

Office

Date on Market:

2026-07-14

Port Washington Office/Medical for Lease - Western Nassau

Turnkey flex offie space ideal for a variety of uses

Property Type:

Flex

Date on Market:

2026-05-21

New York Office/Retail for Lease - Gramercy Park

Ivy 30 at 312-316 East 30th Street offers prime residential living and commercial leasing opportunities within Manhattan’s vibrant Kips Bay neighborhood. This 18-story building blends residential apartments with flexible lower-level space ideal for office or boutique retail use. The available commercial suite offers 2,529 square feet on the lower level, featuring direct elevator access, two restrooms (one ADA-compliant), and an additional lobby area, making it suitable for medical offices, wellness studios, or professional service providers. The property benefits from excellent connectivity, located steps from the 28th Street subway station and within easy reach of multiple transit options. Surrounding amenities include major healthcare networks such as NYU Langone and Bellevue Hospital, educational institutions like NYU College of Dentistry, and a robust roster of retail including Trader Joe’s, Target, and popular dining spots. Kips Bay’s energetic environment, proximity to Stuytown and Peter Cooper Village, and consistent foot traffic support diverse business types. For residents, Ivy 30 provides spacious layouts, modern appliances, hardwood floors, in-unit laundry options, and abundant closet space. Building amenities include a part-time doorman, elevator service, laundry facilities, package room, and live-in superintendent, creating a comfortable living experience in a well-connected location.

Property Type:

Multifamily

Date on Market:

2026-05-07

New York Office, Office/Medical for Lease - Columbus Circle

The Hudson Research Center is a hub for life sciences and medical office space on the west side of Manhattan. The building has some of the only pre-built life science wet lab spaces available for immediate occupancy in the city and is located within a dense cluster of research institutions.

Date on Market:

2026-01-27

Long Island City Office for Lease - Northwest Queens

30-02 48th Avenue, also called the Bindery, is a 165,000-square-foot Class A life science and industrial property located in Long Island City’s Sunnyside neighborhood. Built in 1926 and renovated in 2020, the building provides upgraded infrastructure and flexible design suited to laboratory and R&D uses. It includes four loading docks, on-site security measures, and advanced systems tailored for technical operations. The location offers immediate access to the Long Island Expressway, Queens Boulevard, and multiple subway connections, including the 33rd Street Station on the No.7 line, approximately five stops from Grand Central Terminal.

Date on Market:

2025-06-17

Orangeburg Coworking for Lease - Orangetown

Discover fresh business opportunities in Orangeburg, New York Squeeze every drop out of your business at Orangeburg. Set your business up in Rockland County, a thriving town where job growth over the next six years is predicted to be 27.8%. Choose your favourite way to commute with Western Hwy & Convent Rd Bus Stop just 1.8km away, and Pearl River Train Station just 7.7km away. Looking to increase your business stature on a global scale? Welcome guests from across the United States and overseas at Westchester County Airport, just 34km by car. Use our flexible office space in a way that suits you and your business best. Get all the business support you need to succeed at Orangeburg. Whether you’re collaborating in our fully furnished coworking areas, pitching in our quiet meeting rooms or working solo in our private spaces, our luxurious office building with superfast WiFi gives you the perfect platform to thrive. Visiting clients can’t help but be impressed by the striking modern exterior. They’ll soon feel right at home when given a warm welcome from our reception team and a hot barista-style coffee. Once business is done, let off steam at the local sports complex or chill out in the nearby parks, museum, theatre and cinema.

Property Type:

Office

Date on Market:

2026-06-11