26 Life Science Properties for Lease in Orange County, USA

Irvine Office, Flex for Lease - Irvine Spectrum

HATCHlabs @Irvine Spectrum is a newly renovated, 40,739-square-foot creative office/flex building delivering turnkey wet lab space to emerging science-based companies. Strategically located at 3 Burroughs in Orange County, HATCHlabs @Irvine Spectrum can accommodate various-sized companies. It is particularly well suited for science-based companies eager to grow in place. The science-focused infrastructure and design-forward spaces are planned to optimize recruitment and retain top talent. HATCHlabs @Irvine Spectrum features newly renovated common areas, shared conference and meeting rooms, turnkey and customizable lab suites, and ample parking, with 148 spaces. With a full suite of industrial amenities, HATCHlabs @Irvine Spectrum boasts heavy, submetered power, backup power, rigid floor plates, floor drains, and robust air handling systems. Located in Irvine, California, HATCHlabs @Irvine Spectrum sits in a thriving and remarkably diverse business center. This flex building is close to the Spectrum Center, the Lake Forest Gateway Center, and surrounding retail, entertainment, hospitality, fitness, dining, and lifestyle amenity options. Highway connectivity is a breeze, with heavily trafficked interstates, including Interstates 5 and 405 and Freeway 133, less than a mile away. 3 Burroughs is the premium location to access Irvine's academic and medical anchors. Tenants at the HATCHlabs @Irvine Spectrum will be able to reach UCI Beall Applied Innovation and University Lab Partners at the University of California, Irvine, within a 20-minute drive. Medical facilities, such as the City of Hope Orange County, Hoag Hospital, Edwards Lifesciences, Allergan, and B. Braun Medical Inc., are within a nine-mile radius of HATCHlabs @Irvine Spectrum.

Date on Market:

2025-10-29

Garden Grove Flex for Lease

Property Type:

Industrial

Date on Market:

2026-03-10

La Habra Office/Retail for Lease - Brea/La Habra

Property Type:

Retail

Date on Market:

2026-01-23

Laguna Niguel Flex for Lease - Laguna Niguel/Laguna Beach

This ±12,090 SF industrial building is ideally suited for lab, R&D, or light industrial use. The space includes ±6,500 SF of office, ±4,943 SF of warehouse, and ±1,625 SF of dedicated lab space. Two Class 8 ISO clean rooms provide specialized environments for high-precision operations. The property is divisible and features two ground-level loading doors for flexible logistics. Built in 1984, the building offers a parking ratio of 2.48:1,000 and benefits from immediate access to the 73 and 5 Freeways. With a balanced mix of office, warehouse, and lab space, this facility is well-equipped to support a range of operational needs.

Date on Market:

2025-07-31

Irvine Flex for Lease - Irvine Spectrum

Buildings at TriQuest Business Center feature advanced architectural design that complement the image of established and growing companies. The TriQuest Business Center is centrally located in the heart of Orange County at the intersection of three major freeways. On-site leasing and management. On-site deli and cafe. Suites from approximately 450 - 10,000 square feet. Office, R&D, and Industrial suites available. Industrial suites have ground level roll-up doors. Ample parking available. Parking ratio is 3.75/1000. Pre-improved units available for immediate occupancy. Park-like settings. Master planned 13.7 acre business park. Located in the heart of Orange County' s high tech research and development center. Located at the intersection of 3 major freeways (5, 405, & 133). 1 mile from the Irvine Transportation Center and Rail Station. 1 mile from the Irvine Spectrum. 3 miles from the Irvine Medical Center. 10 minutes from John Wayne Airport.

Date on Market:

2026-02-26

Irvine Industrial for Lease - Irvine Spectrum

Bake Technology Park's prime location is minutes from Irvine Spectrum Center, an entertainment hub boasting Irvine’s best dining, retail, and entertainment options.

Property Type:

Flex

Date on Market:

2024-06-13

Aliso Viejo Office for Lease - Laguna Hills/Aliso Viejo

Located on the corner of Aliso Viejo Parkway and Pacific Park Drive, this four-building campus office environment offers 159,660 square feet of premier space suitable for a wide variety of users. Its contemporary design expertly mixes natural stone elements with glass and stainless steel accents. The dramatic, cantilevered front awnings and warm lobbies provide a welcoming environment for tenants and visitors alike. Large, efficient floor plates lay out well for smaller, multi-tenant users or larger single-occupancy users. Town Center Corporate Park offers ample and convenient surface parking at 4 cars per 1,000 square feet, and is richly landscaped with quiet outdoor seating areas. It is served by the Aliso Viejo Town Center offering a wide variety of shops and restaurants including Opah’s, Chili’s, Macaroni Grill, Wahoo’s, Staples, Barnes & Noble and more. In addition, Marriott Renaissance ClubSport hotel and fitness facility sits just up the street, and access to the 73 Toll Road or the 5 and 405 Freeways is easy and convenient.

Date on Market:

2024-01-23

Santa Ana Industrial for Lease

3,000 SF remaining. Private tenant patio. Natural Gas Service. Fully refurbished building (2023). New roof, windows, doors, restroom fixtures, flooring, etc. "Clean" auto uses acceptable (Upholstery, stereo/electronic, window tint, polishing, detailing, storage). No outside storage of vehicles, however. Other uses: Retail/Service uses, church/religious, veterinary, gym/fitness, child care, general and auto storage, reprographics/printing, painting, laboratory, banquet or venue facility (CUP)

Property Type:

Flex

Date on Market:

2025-12-15

Anaheim Industrial for Lease - North/East Anaheim

This spacious unit offers 4,800 square feet of industrial space along with a fenced yard. This is a corner unit and has access in the front, the side, and back of the unit. With two ground-level doors, loading and unloading are convenient for your business operations. Inside, you’ll find recently refurbished office space and a restroom, providing a modern work environment. Leasing terms are flexible, allowing customization to suit your business needs. Ample parking is available for both employees and clients. Don’t miss out—schedule a viewing today!

Date on Market:

2025-12-03

Garden Grove Office/Medical, Medical for Lease

- 7-Story Medical Office Building - Adjacent to Garden Grove Hospital - Abundant Above Standard Surface Parking - Under New Ownership - Building and Common Area Renovations Planned - Excellent Proximity to 22 & 57 Freeways

Date on Market:

2024-04-02

Irvine Flex for Lease - Irvine/Tustin Legacy

Multi-tenant office building. Centrally located in heart of Irvine IBC. Access to 5, 55 and 405 Freeways. Close proximity to Orange County John Wayne Airport. Retail and dining amenities nearby.

Property Type:

Office

Date on Market:

2024-01-22

Irvine Office for Lease - Irvine/Tustin Legacy

Build to Spec to tenant needs. Can be open concept or have multiple private offices. Landlord is easy to work with to help build your Spec Suite to your needs. EASY TO TOUR! On-Site Property Manager available to TOUR M-F 9AM-5PM by Apt Call/Text 209.480-7802

Date on Market:

2025-11-04

Irvine Office for Lease - Irvine Spectrum

You are the revolutionary working to discover the next breakthrough, wanting to change the present and better the future. Cultivate your next big idea in your exclusive workspace and access the benefits of the larger ecosystem within Discovery Park. Discover your company's next gen.

Date on Market:

2026-02-19

Santa Ana Retail for Lease - Civic Center Area

515 N Sycamore Street offers a prime leasing opportunity in the heart of Santa Ana, just steps from the vibrant Downtown district and across from the historic Old Orange County Courthouse. This six-story office building spans approximately 41,864 square feet and provides a mix of office and retail spaces designed for professional services and boutique businesses. The property’s central location ensures excellent walkability, with easy access to local eateries, retail shops, and cultural attractions, making it an ideal setting for businesses seeking visibility and convenience. The building features controlled access, 24-hour availability, fiber optic internet, and on-site property management, ensuring a secure and efficient work environment. Tenants benefit from both surface and covered parking options, supporting accessibility for employees and clients. With its proximity to Santa Ana Boulevard and major transportation routes, including nearby Metrolink stations, this property offers outstanding connectivity throughout Orange County. Positioned in a dynamic urban setting with strong demographics and a thriving business community, 515 N Sycamore Street is an excellent choice for companies looking to establish or expand their presence in Santa Ana.

Property Type:

Office

Date on Market:

2022-02-02

Huntington Beach Office/Medical for Lease

Renovated Medical and dental office building in downtown Medical District in Huntington Beach. It is a two-story beautiful garden style building which has total 23,271sf on one acre land which provides abundant free parking that is rare in downtown Huntington Beach. Next Building also has a huge parking lot on 2-acre land. All office suites are in an excellent move in condition. Available spaces are from 1187 sf to 1187 sf. All office suites have one or two in-suite bathrooms. Additional disability accessible bathroom is also available in the building. All suites have its own HVAC. Tenants can adjust the temperature to their comfort. All suites have windows which can be opened to get fresh ocean breeze. There are seating areas in courtyard and Hallways for tenants and patients to enjoy fresh ocean breeze which is very good for human health. Newly re-modernized elevator for second story tenants and patients to use. Beautiful water fountain in the courtyard. Current Tenants including Diabetes Clinic, Periodontics Clinic, General Dental Clinic, Foot and Ankle Surgeon Clinic, Dermatologist Clinic, Medical Sports rehabilitation, Medical Laser and Aesthetics, Acupuncture Clinics, Chiropractic Clinics, Women's Health and Wellbeing. The building has Newer low E double pane windows, many of them can be opened to have fresh ocean breeze enter into offices for a healthy working environment. It is in a few minutes walking distance to 5 Point senior living, 5-point plaza and many other shopping centers, Trader' Joe's, restaurants in Downtown area. 2 miles to Huntington Beach Pier, 1.3 Miles to Huntington Beach hospital, 3 miles to Orange Coast Memorial Hospital. The building renovation was done in 2020 to 2021, including new roof, new windows, new colored paint, beautification of the landscape, Re-modernized elevator, signage tower, plumbing and electricals. Please call or text Gexin Tang at 949 836 1888 or email : Tanggexin@yahoo.com for any questions or showing appointment.

Property Type:

Office

Date on Market:

2026-03-05

Irvine Flex for Lease - Irvine Spectrum

This 96,000-square-foot freestanding flex/R&D building is divisible between 24,000 to 96,000 square feet. It is elevator served and has 5,000 square feet of climate-controlled warehouse space with 1 ground-level loading door. Furniture, fixtures, and equipment are available. The building features a dramatic lobby with 48,000 square feet of 2nd floor executive office space including a fitness center and large training room. 3,000 amps 277/480V power with on-site generator and battery backup system for uninterrupted power. Excellent for advanced manufacturing uses. Turn-key R&D lab space is on the first floor with C-arm, chem, and bio-hazard lab. 100% climate controlled facility with freezer and cooler space capabilities. The site features 384 parking stalls for a 4:1,000 parking ratio. Parking is expandable to accommodate larger companies. Property is institutionally owned. Longer lease term possible.

Date on Market:

2026-02-05

Irvine Flex for Lease - Irvine Spectrum

3 Glen Bell Way is a highly efficient Class A building located in the heart of the Irvine Spectrum — one of Southern California’s most desirable corporate submarkets. Offering direct freeway visibility along the I-5 and immediate access to the 405 Freeway, the property provides exceptional convenience for workforce, executive, and client access. Constructed as a premier corporate headquarters, the building delivers a balanced mix of office, open workspace, and high-clear volume areas with robust power, infrastructure, and abundant parking. Its versatile configuration makes it ideally suited for R&D/Tech, Showroom/Design Center, Life Science, and Industrial/Office occupiers.

Date on Market:

2025-12-03

Huntington Beach Industrial for Lease

Date on Market:

2025-10-06

Irvine Flex for Lease - Irvine Spectrum

9233 Research Drive | Irvine, CA Upscale Office Sublease | 100 – 6,515 SF Available Located in the heart of Irvine’s thriving business district, 9233 Research Drive offers a flexible sublease opportunity ideal for a variety of professional uses — from corporate offices to churches, non-profits, and community organizations. This upscale space is available in its entirety (6,515 RSF) or can be leased as individual executive offices.

Date on Market:

2025-07-15

Placentia Industrial for Lease - Placentia/Yorba Linda

- Free-standing R& D Type industrial building - Knott's Business Park - Lot area:32,582 SF - Total building area : 16,534SF (1st floor:14,298SF , 2nd floor2,236SF ) * Total 1st and 2nd floor office space:3,744SF * * +/- 585SF at 1st floor area with Ceiling / Lights/ HAVC . * +/- 620SF at 2nd floor :Open Loft area with Kitchen sink and Cabinets is not included in the total building area. - Ceiling height : 22 Ft - Loading: One 10' x 10 ' Ground Level Drive-in Door & One Interior Truck Well (Dock Height loading) - Power: Upgraded (Verify) - Fully Fire sprinklered - Four HAVC units on the roof - Six 4'x 8' smoke Vent & Sky Lights - 31 Parking stalls (Parking ratio:1.87/1,000SF ) - Built In 1986

Date on Market:

2025-07-06

Irvine Office for Lease - Irvine Spectrum

Discover productivity at Tripointe, a convenient workplace community featuring industrial units with loading doors, warehouse space, ample parking, and onsite retail to ensure your teams experience the best of work and the best of life each workday.

Property Type:

Flex

Date on Market:

2024-07-01

Irvine Flex, Industrial for Lease - Irvine Spectrum

Unique Green Building Design.

Date on Market:

2025-10-30

Santa Ana Office/Medical, Medical for Lease

Date on Market:

2026-03-03

Santa Ana Office/Medical, Medical for Lease - Main Place Area

Medical & Professional Campus, with easy FWYS 5, 22, 55, 57 access, Surface Parking with Ratio of 6 per 1,000. On site Medical Lab, State of the Art Medical Imaging &Radiology and Pharmacy, State of art Tenant Improvement available for qualified tenant. Visible from the 5 Freeway and Immediate Access to 3 Major Southern California Freeways, 5, 22, 55 and close proximity to 57, Located next to the Hard Corner of 17th Street and Grand Avenue with the car count of approximately 80,000 cars per day.

Date on Market:

2025-04-16