8 Life Science Properties for Lease in Orlando, FL, USA

• Matterport 3D Tour

One Performance Plaza Office and Medical - 6424 Alexandra Louise Dr

Orlando, FL 32827

• Life Science
• Office/Medical for Lease
• 2,000 - 65,183 SF
• 2 Spaces Available Now

• Air Conditioning
• Security System
• Car Charging Station
• Concierge
• 24 Hour Access
• Fitness Center
• Wheelchair Accessible
• Smoke Detector

Orlando Office/Medical for Lease - SE Orange Outlying

Located in the heart of Lake Nona Town Center, One Performance Plaza is a cutting-edge, Class A office tower. Its direct connection to the Lake Nona Performance Club - a medically integrated sports, performance, and fitness center - makes this property an ideal location for medical practices and professional office tenants alike. One Performance Plaza offers Class A medical and office space in walking distance to restaurants, hotels, and is on the Beep autonomous shuttle route. This 300,000-square-foot, state-of-the-art facility provides tenants and their employees and patients with direct access to exclusive health services and programming. The 6th-floor penthouse includes private elevator access, with the possibility of crown signage for a full-floor tenant. Tenants and their visitors will appreciate the canopied drop off area, close surface parking, and garage parking at no additional parking cost as well as the walkability of the Town Center location where restaurants, hotels, and conference centers are in close walking distance. Lake Nona wet lab, biotech space available at deeply discounted sublease rates. One Performance Plaza is adjacent to a globally recognized health and life sciences cluster, including Nemours Children’s Hospital, the Orlando VA Medical Center, UCF Lake Nona Hospital, UCF College of Medicine and Academic Health Sciences Campus, UCF College of Nursing, UF Research and Academic Center, UCF Lake Nona Cancer Center, and GuideWell Innovation Center. 6424 Alexandra Louise Drive overlooks a beautifully landscaped park with outdoor seating, walkable to several restaurants and hotels, including Chroma Modern Bar + Kitchen, Bosphorus Turkish Restaurant, Park Pizza & Brewing Company, Residence Inn & Courtyard by Marriott, and the Lake Nona Wave Hotel & Conference Center. Desirable features include EV charging stations in the multi-level garage and an independent shuttle system for convenient transportation throughout the center. The property provides easy access to State Routes 417 & 528, Florida's Turnpike, Orlando International Airport and Brightline Orlando Station. Lake Nona is a 17-square-mile community built and anchored by clusters of excellence in well-being, sports and performance, education and technology. Thoughtfully designed with a long-term vision, this fast-growing, neo-urban environment provides a unique commercial climate where companies make a lasting impact. Tavistock provides best-in-class infrastructure and facilities to corporate partners, and Lake Nona’s attractive business ecosystem draws visionary companies and entrepreneurs from across the globe to join its living lab environment.

Contact:

Lake Nona Land Company, LLC

Property Type:

Office

Date on Market:

2024-11-07

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Arden Hill Medical Center - 6388 Silver Star Rd

Orlando, FL 32818

• Life Science
• Medical for Lease
• $29.31 CAD SF/YR
• 1,375 - 8,406 SF
• 4 Spaces Available Now

Orlando Medical for Lease - West Colonial

Along the high-visibility Silver Star Road corridor in western Orlando, Arden Hill Medical Center at 6388 Silver Star Road offers medical professionals the opportunity to secure well-connected, modern, and highly functional space. Standing out with its distinctive architectural design, this unique two-story, 25,440-square-foot medical facility offers accommodating features, including a covered porte-cochère for protected drop-offs, ample surface parking, and convenient elevator access. Available suites are built out for various medical uses, offering a plug-and-play setup ideal for pediatricians, physical therapists, mental health providers, dermatologists, diagnostic imaging centers, and more. Most suites include patient waiting areas, private exam rooms, administrative and medical filing zones, lab-ready infrastructure, and break rooms. On-site maintenance ensures daily operations run smoothly, while secured exit doors and individualized access codes provide peace of mind after hours. Monument signage offers strong branding visibility along this major east-west thoroughfare, which links Interstate 4 with State Road 429 (Western Beltway), serving over 40,000 vehicles daily (VPD). Situated in one of the city's most established working-class neighborhoods, Arden Hill Medical Center benefits from swift connections to AdventHealth Orlando and Health Central Hospital in 12 minutes and a mere half hour from Orlando International Airport (MCO), making it exceptionally well-positioned to meet the area's growing demand for healthcare. With a projected 2.65 percent increase in household growth from 2024 to 2029, the surrounding community continues to expand, creating ideal conditions for new and established practices to thrive.

Contact:

Lee & Associates Central Florida, LLC

Property Type:

Office

Date on Market:

2025-10-21

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Medical Village At Pine Hills - 800-840 Mercy Dr

Orlando, FL 32808

• Life Science
• Office for Lease
• $22.33 - $43.97 CAD SF/YR
• 2,518 - 19,314 SF
• 4 Spaces Available Now

• Air Conditioning

Orlando Office, Industrial for Lease - West Colonial

Introducing 800 Mercy Drive, a premier commercial property offering an exceptional lease opportunity in Orlando, Florida. This versatile building features both medical and industrial space options, making it ideal for a wide range of professional and operational uses. The property offers Tenant Improvement (TI) allowances, enabling you to tailor the space to your exact business requirements. With a spacious layout, ample parking, and a convenient Orlando location, 800 Mercy Drive provides the perfect foundation for your enterprise to grow and succeed in a dynamic market.

Contact:

SVN | Commercial Advisory Group

Date on Market:

2025-07-25

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Flex Office/Warehouse | Orlando - 805 W Central Blvd

Orlando, FL 32805

• Life Science
• Flex for Lease
• $18.84 CAD SF/YR
• 7,444 SF
• 1 Space Available Now

• Air Conditioning
• Bio-Tech/ Lab Space
• Private Restrooms
• 24 Hour Access

Orlando Flex for Lease - Downtown Orlando

West Central Center is nestled in the heart of Downtown Orlando the area offers convenient access to prominent landmarks such as Orlando Health and AdventHealth Orlando, providing excellent industrial and warehouse resources for employees. Diverse culinary options and retail amenities can be found at the nearby Orlando International Premium Outlets and The Mall at Millenia. Located minutes from downtown Orlando, the area boasts a dynamic atmosphere, ideal for attracting top talent. With its central location, the property offers an unparalleled opportunity for Office/warehouse users to thrive in the heart of Orlando's bustling market.

Contact:

Millenia Partners

Date on Market:

2025-02-03

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SouthPark Center - 8529 South Park Cir

Orlando, FL 32819

• Life Science
• Office and Flex for Lease
• 2,617 - 613,956 SF
• 18 Spaces Available Now

• Air Conditioning
• Natural Light
• Reception

Orlando Office, Flex for Lease - Tourist Corridor

Home to national and international companies, SouthPark Center is a Class A office park offering turnkey suites convenient to all of Orlando’s points of interest. Consisting of 13 buildings and a total of 1,540,000 square feet of office space on a pristine 162-acre campus, SouthPark Center presents users with suites ranging in size from 5,822 to 38,229 square feet, many of which are move-in-ready and perfect for a variety of businesses. The LEED-certified buildings have undergone extensive renovations, including signage throughout the park, new lobby updates in select buildings, an on-site fitness center, a Nature’s Table café, and a state-of-the-art conference and hospitality center. Highlighting the campus are high-end amenities that include a new foot truck court, outdoor gathering areas with games, on-site car detailing, and on-site dry cleaning. SouthPark Center also offers convenient commutes to and from the site via proximity to I-4, State Route 482, State Route 441, and the Florida Turnpike. The abundance of nearby transportation options helps drivers reach all of Orlando’s major points of interest, like The Orange County Convention Center, International Drive, Universal Studios, Sea World, and the Central Business District in under a 20-minute drive. Additionally, it is minutes from the home offices of corporate giants like AT&T, Publix, Lockheed Martin, Walgreens, and Office Depot, showcasing the area's desirability.

Contact:

CBRE, Inc.

Date on Market:

2025-10-02

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Medical Village at Maitland - 7900 Forest City Rd

Orlando, FL 32810

• Life Science
• Office/Medical and Medical for Lease
• 2,569 - 9,694 SF
• 2 Spaces Available Now

Orlando Office/Medical, Medical for Lease - Maitland Center

This property is a part of a centrally located medical complex in Orlando, Florida, with prime, move-in-ready medical office space featuring private entrances, building signage opportunities, and attractive landscaping. The Medical Village at Maitland’s on-site services includes children’s mental health, chiropractic, recovery, dialysis, nephrology, radiology, oncology, a full-service lab, and a community health center. The building is within walking distance of a bus stop and is located 6 miles from AdventHealth Altamonte Springs, 8 miles from AdventHealth Winter Park, and 11 miles from OrlandoHealth Regional Medical Center.

Contact:

Lincoln Property Company

Date on Market:

2023-08-30

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GuideWell Innovation Center - 6555 Sanger Rd

Orlando, FL 32827

• Life Science
• Office for Lease
• 2,103 - 46,106 SF
• 1 Space Available Now

• Air Conditioning
• Bio-Tech/ Lab Space
• Car Charging Station
• 24 Hour Access
• Conferencing Facility

Orlando Office for Lease - SE Orange Outlying

The GuideWell Innovation Center is a state-of-the-art commercial, multi-tenant life sciences building designed to promote autonomous wet laboratory and office uses in the heart of Lake Nona Medical City. Up to a full floor is available at sublease rates. The 650-acre health and life sciences park is a landmark for Orlando and a premier location for medical care, research and education. Lake Nona Medical City represents a deliberate strategy to create a centralized focus of sophisticated medical treatment, research, and education in Central Florida. Lake Nona is located in Orlando, just 10 minutes from Orlando International Airport. One mile from Lake Nona Town Center featuring a thoughtful collection of premium restaurant, retail, hotel, and conference space offerings.

Contact:

Lake Nona Land Company, LLC

Date on Market:

2022-05-27

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Discovery Lakes Phase 2, Bldg 1 - 2721 Discovery Dr

Orlando, FL 32826

• Life Science
• Flex for Lease
• 47,284 - 55,105 SF
• 1 Space Available Now

• 24 Hour Access

Orlando Flex for Lease - University Research

Located in the Central Florida Research Park, this 55,105 SF property offers excellent access to SR 417, SR 408, Orlando’s CBD, and Orlando International Airport. Just steps from the University of Central Florida, the site sits on 6.5 acres and includes nearby amenities like hotels, dining, and numerous housing options. Ideal for businesses seeking a flexible, well-connected location.

Contact:

Foundry Commercial

Date on Market:

2025-02-19

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