63 Life Science Properties for Lease in Pennsylvania, USA

Exton Flex for Lease - Exton/Whitelands

Geared toward lab and life science users, 100 Arrowhead Drive is an upcoming flex facility in Exton, Pennsylvania’s booming life science cluster. The 60,300-square-foot building pairs thoughtful design with environmentally friendly operation. 100 Arrowhead Drive is poised to become the jewel of the 800-acre Eagleview campus. Situated on 13.60 acres, the site is currently under development by Hankin Group, a full-service and family-owned real estate company that designs, develops, and manages residential and commercial properties. 100 Arrowhead provides tremendous brand value as one of a few properties with visibility from the Pennsylvania Turnpike. The site can accommodate an array of flex, research and development, and lab uses with up to 6,000 amps of electric power available. Other property features include three dock doors for efficient loading, a 24-foot clear height, tenant-tailored office and lab space, and up to 218 parking spaces. Philadelphia stands tall among the top 10 life science markets in the United States, boasting a rich ecosystem that fuels groundbreaking research and medical advancements. Eagleview’s accessibility and proximity to downtown Philadelphia, the Philadelphia Airport, and the region’s life science ecosystem have been a recipe for success for our life science tenants. The campus is home to 10 life science companies, including Takeda and West Pharmaceutical, within walking distance to the highly amenitized Eagleview Town Center and convenient to Route 100 and the Pennsylvania Turnpike connectivity.

Date on Market:

2024-04-23

Philadelphia Multiple Space Uses for Lease - Northeast Philadelphia

401 N Broad St, built in 1930, was originally known as the Terminal Commerce Building, occupying an entire city block at Broad and Callowhill Streets. The massive edifice even had a freight station beneath it, which replaced the Reading's North Broad Street Freight Station and rail yard that had previously been on the site. The building houses a diverse mix of tech, creative and innovative tenants. DATA CENTER: The property is a renowned international gateway and a major data center between Manhattan and Virginia and houses over 100 service providers. Philadelphia is home to extensive long haul and metro fiber routes and a major junction for the north-south domestic fiber routes on the east coast. The location provides long-term stability and premier data center services for its customers. LIFE SCIENCES: The building contains state-of-the-art turnkey and build-to-suit life science labs providing space for incubator to graduate level lab tenants. CREATIVE OFFICE: The building lays-out beautifully for creative office users due to it's 12-foot ceilings, classic mushroom columns, large contiguous spaces and good window line. It is home to Nerd Street Gamers corporate headquarters and LocalHost street level gaming center.

Date on Market:

2024-07-15

Pittsburgh Office, Flex for Lease - East End

The Edison at 201 N Braddock Avenue offers dynamic flex and office space, ideally located in the bustling Rockwell Park redevelopment in Pittsburgh's East End. This six-story, 200,000-square-foot building boasts efficient floor plates for flexible configurations, high ceiling heights, and large windows allowing abundant natural light and sweeping city views. A variety of office space, industrial flex, creative lofts, mixed-use, and research and development space exists, ranging from whole floor plates to small singular office users. The expansive layout encourages collaboration and innovation, making it an ideal environment for businesses looking to foster a dynamic and productive work culture. Current tenants already calling The Edison their home include a vibrant mix of art studios, photographers, designers, prototyping, robotics, tech and development tech companies from single users to Fortune 500 companies. Rockwell Park is a transformative, 24-acre mixed-use redevelopment campus consisting of office, advanced manufacturing, light industrial, retail, and multifamily space located in the heart of Pittsburgh. This owner-operated campus-style site hosts a robust collection of community-based amenities designed for during and after work including shared kitchens, locker rooms, showers, mailrooms and more. Functional amenities facilitating our tenant’s self-sufficiency include ground level loading docks with tall ceiling heights and large windows. Flexible space from tenant lounges to collaboration areas provides a change of scenery throughout the work day or accommodates group breakouts. Throughout the park are several outdoor terraces patios and seating areas, promenades accentuated by professional landscaping, event space, concierge, and ample on-site parking and bike storage. A wealth of walkable retail and restaurants are present, including East End Food Co-op, Fresh International Market, Commonplace Coffee, and more. The East End Food Co-op is part of Rockwell's campus, and Construction Junction is a valued neighbor. Once home to transformative business leaders like Heinz, Carnegie, Edison, Westinghouse, and Rockwell, this vibrant area is poised to inspire the next generation of innovators. Point Breeze neighborhood is made up of prominent residential communities, community-based businesses, museums, and the region's largest urban green space in Frick Park. Centrally located with easy accessibility and superior convenience, The Edison at Rockwell Park is positioned a five-minute drive to Interstate 376 and Route 28 and a 15-minute drive to Downtown Pittsburgh. Pittsburgh International Airport is a 30-minute drive away for convenient out-of-town travel. Access to a deep talent pool from the surrounding residential areas, leading innovative organizations, and higher education establishments, including the University of Pittsburgh, Carnegie Mellon University, and 3M, are some of the many reasons robotics, software, coding, data analytics, Large Language & Generative AI pioneers are attracted to this area. Pittsburgh is also home to Carnegie Mellon's Robotics Institute, the world's most extensive robotics R&D program, as well as the Advanced Robotics for Manufacturing Institute and the National Robotics Engineering Center, among others.

Date on Market:

2025-07-23

Philadelphia Flex for Lease - Northwest Philadelphia

A site rich in history, Budd Bioworks has innovation at its core. Philadelphia’s role in pioneering advances in the manufacturing and automobile industry brought leading businesses, including The Budd Company. It was the first to introduce the all-steel automobile body, the first diesel-powered stainless steel streamliner train, and the first stainless steel passenger railroad cars. It grew into a multibillion-dollar, global organization right on this site. The revitalization of the historic Budd plant is delivering a campus for science in all stages, from discovery to production. Both ready-to-go and future space for various lab services and biomanufacturing provide an epicenter for businesses to grow and evolve. The Budd Innovation Center, located at 2450 W Hunting Park Avenue offers fully built out, Class A working environments covering four floors and a fit-out ready Annex, meeting a variety of needs for life science users ranging from R&D, Lab, Incubator Space, Technical or Training Facilities, Vivarium, and Pilot Scale Manufacturing and up to Full-Scale Manufacturing. Across West Huntington Park Avenue, at 3431 Fox Street, space is immediately available for large-scale bioproduction within the Pioneer Building. An additional two buildings can support substantial future capacity at 3431 Fox Street under Phase 2 of the development. As a vibrant corner of industry and redevelopment, the Budd is a nexus to City Center Philadelphia and its surrounding suburbs. Easily accessible from Route 1 and Route 13, just a few blocks from SEPTA’s Allegheny Station, Budd also conveniently offers access to more than 700 free parking spaces on-site, the most abundant free office parking in the City of Philadelphia. Budd Bioworks is located 15 minutes to University City at the epicenter of “Cellicon Valley” and near esteemed college grounds, including Temple Hospital and Medical School, Thomas Jefferson University East Falls Campus, and Drexel University College of Medicine. Employees and visitors alike will enjoy nearby retail services, including ShopRite, Wendy's, Chipotle, T-Mobile, and recreational access at the adjacent Kroc Center. The campus is primed for occupancy to continue its legacy as a hub for innovation, boasting amenities including courtyard space, a fitness center, and conveniently placed bus stops surrounding the campus.

Date on Market:

2024-08-08

Pittsburgh Office, Office/Medical for Lease - South Pittsburgh/Rte 19

Upper St Clair's Summerfield Commons Office Park is home to many successful business, the strategic location and peaceful atmosphere make our park perfect for any business looking for accessibility while avoiding noise and congestion. Summerfield offers professionals a park like setting, walking trails, on-site maintenance, and waterscapes. The property consists of 11 Buildings, totaling 93,742 square feet and a variety of suite ranging from 681 square feet to 4,930 square feet. Conveniently located in the heart of Upper St. Clair, at the corner of Boyce Road and Rt. 19, is in close proximity to shopping, dining establishments, and major roadways such as I-79 and I-376. Only 10 miles from downtown and within 20 of Pittsburgh International Airport. Additional Features Include: -Individual Climate Controls -Private Entrances -Private Restrooms -Spaces can be Built-to-Suit -Office Views of Park & Waterscapes

Date on Market:

2026-01-02

Pittsburgh Office, Retail for Lease - Parkway West Corridor

Foster Plaza 8 – Pittsburgh Office Space 730 Holiday Drive | Pittsburgh, PA 15220 1,500 – 24,297 SF | Class A Office Space at Class C Pricing Foster Plaza 8 offers renovated Class A office space with flexible layouts and modern amenities at unbeatable rates. Located in Pittsburgh’s Green Tree business corridor, this building is ideal for a wide range of businesses. Property Highlights: - Class A space at Class C pricing with price-beat guarantee - Renovated interiors with LED lighting and updated lobby - Fitness center with showers - On-site café, hotel, daycare, and access to Greentree Sportsplex - Immediate access to I-376; minutes to Downtown and airport - Free surface parking - Part of a 1.1M SF, 12-building corporate campus Ideal Tenants: - Professional services (financial advisors, insurance agencies) - Legal practices and consulting firms - Tech startups and IT service providers - Healthcare specialists and boutique medical practices - Marketing, media, and design firms - Educational and training centers - Nonprofits and community organizations - Showrooms and customer service hubs - Retail concepts (restaurants, cafés, food service) - Wellness and beauty businesses (salons, barbershops, medspa) - Real estate offices and property management groups - Engineering and architectural firms - AI and tech companies (data centers, robotics, cloud computing, cybersecurity) - Corporate innovation labs and R&D offices - Startups and incubators Immediate occupancy | Flexible layouts | Price-beat guarantee Contact John Lam – Direct Leasing – President – Bluestone PMS 484-747-5776

Date on Market:

2026-06-05

Pittsburgh Office for Lease - Greater Downtown

Located in the heart of Pittsburgh’s Uptown innovation corridor, the Forbes Pride & Stevenson Buildings offer a rare opportunity to lease flexible, high-impact space in two architecturally distinctive, adjacent properties. The Forbes Stevenson Building features 14,661 square feet of prime ground-floor space in a landmark listed on the National Register of Historic Places—ideal for lab, medical, office, or nonprofit use. Just next door, the Forbes Pride Building delivers over 48,000 square feet of beautifully converted factory-loft office, medical, therapy and lab space with soaring ceilings, arched windows, and floor plates ranging from 1,350 to 13,200 square feet. Both buildings are directly across from UPMC Mercy and steps from Duquesne University’s new medical school, surrounded by major institutional and mixed-use developments. Tenants benefit from abundant natural light, modern infrastructure, on-site parking, in-person security, and professional management. With direct access to the new Bus Rapid Transit University Line and proximity to major highways, these properties offer unmatched connectivity. This is a unique chance to secure space that blends historic character, modern functionality, and strategic positioning in one of Pittsburgh’s most dynamic and rapidly evolving neighborhoods.

Date on Market:

2025-06-24

Levittown Flex for Lease - Lower Bucks County

Date on Market:

2026-06-15

Harrisburg Office for Lease - Harrisburg Area East

Prime riverfront office suites are available at 3211 North Front Street, Harrisburg, sitting on a 1.3-acre professional campus. Two 11,000 SF suites—one ready now, one available January 1—offering beautiful Susquehanna River views, ample parking, and easy access to I-83 and the Pennsylvania Turnpike. These suites are ideal for life science companies seeking adaptable space, with ownership willing to subdivide and modify for lab or research needs. Whether you're a biotech firm, medical office, or a professional service, these suites can be tailored to support your unique operations. Asking lease rate: $19 to $22 per square foot, based on tenant improvements and suite configuration. The total space is 10,000 square feet, and it can be leased as one suite or subdivided to fit your needs. Contact us to discuss your ideal layout

Date on Market:

2026-06-05

Pittsburgh Multiple Space Uses for Lease - Greater Downtown

2500 Jane Street offers versatile and conveniently located commercial spaces ideal for a variety of business uses. This two-story brick building features an elevator and is positioned in a well-traveled corridor. This property provides excellent visibility, accessibility, and proximity to major city routes.

Date on Market:

2026-03-11

Philadelphia Multiple Space Uses for Lease - Market Street West

1421 Race Street – Flexible Clinical, Lab & R&D Space in the Heart of Center City Race Street Labs | Philadelphia, PA Position your team at 1421 Race Street, home of Race Street Labs — a strategic life science and innovation hub in Center City Philadelphia. Just steps from major medical institutions and easily accessible from regional transit, the building offers a unique mix of clinical, lab, and flex/R&D space designed to support organizations at every stage of growth. Premium Lab Suites – Ready for Immediate Move-In Race Street Labs features a private full-floor lab suite engineered for biotechnology, microbiology, chemistry, and other advanced research operations. This move-in ready suite combines functionality, safety, and comfort to support serious science: Two 6-foot Venturi fume hoods Four lab sinks with gooseneck faucets and eyewash capability Three large lab islands with approximately 16 powered workstations Large open-concept team office plus two private executive offices Dedicated storage and IT/server rooms Two private restrooms within the suite Private kitchen and break area Emergency shower and eyewash station Automatic motion-sensor lighting Backup generator and dual 13,200V power feeds Lab HVAC exhaust system and circulating chilled water Freight elevator and loading dock access for equipment delivery On-site facility and lab management team This suite spans an entire floor, providing the security, exclusivity, and infrastructure required for focused research and innovation. Clinical & Medical Office Opportunities In addition to lab-ready space, 1421 Race Street offers unfinished clinical / medical office space on an upper floor that can be tailored to healthcare users. The open plan allows for customized layouts including exam rooms, consultation rooms, treatment areas, and administrative offices—ideal for medical practices, specialty clinics, or clinical support services seeking a modern, elevated setting in Center City. Flex & R&D Space An additional unfinished flex/R&D floor is available for teams that need adaptable space for: Research and development Product testing and prototyping Innovation labs or technical office use Hybrid lab/office or engineering environments The open, as-is layout provides the flexibility to design collaboration areas, workstations, labs, or light technical space around your specific operational requirements. Building Amenities Race Street Labs blends scientific performance with workplace comfort: Structured parking available within one block 24-hour keycard access Coffee bar and lounge area Large main-level conference room Indoor bike storage Ping pong and recreation area Virtual golf simulator Shower and locker facilities for tenant use Why 1421 Race Street Customizable environments for clinical, lab, and R&D users Robust infrastructure optimized for life science and innovation Flexible office and collaboration configurations On-site management and maintenance support Unbeatable Center City location in a growing biotech and healthcare corridor In addition to the move-in ready lab suite, additional lab and flex spaces are in development and can be built to tenant specifications — whether you need expanded wet lab capacity, specialized environments, or integrated office and collaboration zones. Schedule a private tour of 1421 Race Street to explore how our clinical, flex, and lab offerings can support your team’s next chapter of growth.

Date on Market:

2025-11-22

Pittsburgh Office for Lease - Parkway West Corridor

Date on Market:

2025-09-25

King Of Prussia Multiple Space Uses for Lease - King of Prussia/Wayne

Date on Market:

2026-04-01

Philadelphia Flex for Lease - Navy Yard

Positioned in the heart of the Philadelphia Navy Yard, 2500 League Island Boulevard offers a rare opportunity to lease award-winning cGMP-ready space within one of the region’s most dynamic life sciences hubs. This 130,307-square-foot R&D flex/industrial facility sits on 6.5 acres and is designed to accommodate tenants from 40,000 to 130,000 square feet, making it ideal for growing biotech firms and advanced manufacturing operations. Crafted by SITIO Architects and targeting LEED v4 Silver Certification, the building features 30-foot clear heights, 9’x10’ dock doors with knock-out panels for customizable loading, and a structurally upgraded roof (60 PSF) to support tenant equipment. The floor slab supports a 250 PSF live load, and the column spacing of 40’x50’/60’ ensures flexible interior layouts. Tenants benefit from dual electric circuits, a 1500kVa transformer (upgradeable), and immediate access to high-pressure gas, water, sewer, and fiber broadband. Strategically located just 5 miles from Philadelphia International Airport and 6.8 miles from Center City, the site offers direct access to I-95 and the Walt Whitman Bridge, connecting users to New Jersey and the broader Mid-Atlantic corridor. The Navy Yard’s vibrant ecosystem, anchored by life sciences innovators, provides a collaborative environment and access to top-tier talent. As part of the Keystone Opportunity Zone (KOZ), qualified tenants may receive substantial state and local tax benefits, enhancing the financial appeal of this premier location.

Date on Market:

2024-12-05

Plymouth Meeting Flex for Lease - Plymouth Mtg/Blue Bell

The property offers ample parking and is strategically located near major transportation routes.

Property Type:

Office

Date on Market:

2024-10-09

Lancaster Office for Lease - Lancaster County

Beautiful Class A Office 6,468-21,000 Located just off two US Route 30 exits yet positioned in the heart of the PA Dutch country. Enjoy all the benefits of the Greenfield Corporate Center.

Property Type:

Specialty

Date on Market:

2024-11-12

Philadelphia Retail for Lease - University City

Situated directly across the Schuylkill River from Center City, University City is the easternmost portion of West Philadelphia, encompassing several Philadelphia universities. Home to the University of Pennsylvania, Drexel University, and the University City campus of Saint Joseph’s University. The Penn and Drexel campuses contain several medical institutions, independent centers of scientific research, and 30th Street Station, one of the nation’s busiest passenger train stations.

Property Type:

Multifamily

Date on Market:

2024-04-09

Hollidaysburg Office for Lease

The newly blacktopped driveway entrance and parking lot will greet your customers and employees as they travel into this established multi-company business park. Suite 106 will welcome you with modern carpeting as you walk through the multitude of offices. This facility could be utilized for a variety of different options. Last use was Banker Life Insurance Company. Could be suitable for social services, professional space, sales, health and wellness. Your dream is your ceiling.

Property Type:

Flex

Date on Market:

2025-03-14

Easton Office/Medical for Lease - Lehigh Valley

Excellent opportunity to access turnkey medical office space in growing suburb of Easton, PA. Choose from varying sizes of office, medical, professional services space on 4 floors. Or bring your growing surgery practice to the turn-key 3rd Floor 10,000 sq. ft. ideal for orthopedic, joint replacement and other out-patient surgeries.

Property Type:

Office

Date on Market:

2023-08-28

York Industrial for Lease - York County

Industrial space available in the Acco Business Park at 75 Acco Drive in York, PA. This business park, located just off S. Queen St./Route 74, offers easy access to Interstate-83. Warehouse/flex space complete with loading docks and drive-in doors. Ideal location for contractors, wholesalers and warehouse uses. Space available located in either Building A or B. Suite A 3 is 3,000 SF with storefront windows and a single loading dock to the rear. Suite B 8-9 is 10,950 SF, and has four (4) loading docks and two (2) drive-in doors.

Date on Market:

2026-03-13

Pittsburgh Office for Lease - East End

Date on Market:

2024-12-04

Canonsburg Office for Lease - Washington County

4 Grandview Circle is a multi-tenant, two-story office building located in Canonsburg. The property offers an abundance of free parking.

Date on Market:

2022-05-16

Butler Office for Lease - Butler County

Three floor medical office building adjacent to Butler Memorial Hospital. Minutes from the heart of Butler and Route 8. 63 on-site free parking spaces with 5 handicap-accessible spaces and additional free parking in the adjacent hospital parking garage.

Date on Market:

2020-09-30

Philadelphia Office for Lease - Independence Hall

Designed, engineered and built to carry the weight and withstand vibrations of massive printing presses, the iconic Curtis is poised to become a world class conversion and meet the comprehensive space needs of the surging life science community. Located within America's most historic mile, this Philadelphia Landmark is as relevant today as it was the day it was built. No other building in Philadelphia can offer the base features required for speed to market, as can The Curtis. The Curtis has: 220 lb floor loads, dual 13,200 v electric feeds, back- up generators, excess shaft space for exhaust, circulating chilled water throughout, two (2) freight elevators 4,500 and 5,500 lbs capacity, four (4) fresh air intakes per floor, 12 story atrium providing double the amount of natural light, 14' 6'' ceiling heights and last but not least, is the permanent home of "The Dream Garden" the 100,000 piece glass mural designed by Mayfield Parrish and built by Tiffany Studios.

Date on Market:

2023-03-02