35 Life Science Properties for Lease in Philadelphia, PA, USA

Philadelphia Office for Lease - University City

Located in Philadelphia's thriving life science ecosystem, 3151 Market Street offers state-of-the-art lab space and premier amenities designed with sustainability at the forefront. This next-generation building provides up to 406,695 square feet of flexible space, including up to 60% of lab and 40% of office space, with large 39,000-square-foot floor plates, 15-foot floor-to-ceiling heights, top-tier infrastructure, emergency power, and extra floor loading capacity. Commercial space is available for lease on the ground floor, offering retailers high-quality space with a built-in customer base. 3151 Market Street is perfectly suited to accommodate a diverse range of life science tenants and retail businesses. The Class A building also offers a range of on-site amenities designed to enhance the tenant experience. These include touchless entry, secure bike storage, a café, parking, and a versatile indoor/outdoor collaborative space. On the second floor, the event area provides the perfect setting for small team meetings, town hall gatherings, and collaborative activities, while the adjacent eco-terrace offers tenants an opportunity to step outside and enjoy views of Woodland Walk and University City. The building offers a unique feature known as the Eco Porch on alternate floors, providing direct access to an outdoor oasis designed to support tenant well-being and comfort. Ideally located in University City, 3151 Market Street is surrounded by a dense network of prestigious educational and medical institutions, including Drexel University, the University of Pennsylvania, The Wistar Institute, and The Children’s Hospital of Philadelphia. This prime location fosters collaboration, research, and development, offering businesses unparalleled access to quality talent and cutting-edge research facilities. The building is also strategically positioned across the street from Schuylkill Yards, a multimodal hub with seamless access to train, mass transit, major highways, and bike or pedestrian routes, including direct connections to Interstates 76, 95, and 676. Well-served by transportation options, 30th Street Station is just steps away, providing Amtrak service to Washington, DC, and New York City within 1.5 hours, while Philadelphia International Airport is only an 18-minute drive away for convenient national and international travel. 3151 Market Street is at the heart of Philadelphia’s dynamic community, being steps from vibrant dining, local shops, renowned restaurants, premier hospitality, and cultural landmarks. University City continues to solidify its position as one of the nation's top life science hubs, ranked fourth in the country. The area boasts a highly educated workforce, with over a quarter-million residents within a 2-mile radius, 56% of whom hold a bachelor’s degree or higher. This vibrant area is a magnet for businesses looking to leverage Philadelphia’s affordability, access to talent, and a supportive environment for growth. With a dynamic blend of academic institutions, cutting-edge research facilities, and a growing number of life science ventures, 3151 Market Street presents a unique opportunity for businesses to establish themselves at the intersection of innovation and excellence.

Date on Market:

2024-03-12

Philadelphia Multiple Space Uses for Lease - Northeast Philadelphia

401 N Broad St, built in 1930, was originally known as the Terminal Commerce Building, occupying an entire city block at Broad and Callowhill Streets. The massive edifice even had a freight station beneath it, which replaced the Reading's North Broad Street Freight Station and rail yard that had previously been on the site. The building houses a diverse mix of tech, creative and innovative tenants. DATA CENTER: The property is a renowned international gateway and a major data center between Manhattan and Virginia and houses over 100 service providers. Philadelphia is home to extensive long haul and metro fiber routes and a major junction for the north-south domestic fiber routes on the east coast. The location provides long-term stability and premier data center services for its customers. LIFE SCIENCES: The building contains state-of-the-art turnkey and build-to-suit life science labs providing space for incubator to graduate level lab tenants. CREATIVE OFFICE: The building lays-out beautifully for creative office users due to it's 12' ceilings, classic mushroom columns, large contiguous spaces and good windowline. It is home to Nerd Street Gamers corporate headquarters and LocalHost street level gaming center.

Date on Market:

2024-07-15

Philadelphia Flex for Lease - Northwest Philadelphia

A site rich in history, Budd Bioworks has innovation at its core. Philadelphia’s role in pioneering advances in the manufacturing and automobile industry brought leading businesses, including The Budd Company. It was the first to introduce the all-steel automobile body, the first diesel-powered stainless steel streamliner train, and the first stainless steel passenger railroad cars. It grew into a multibillion-dollar, global organization right on this site. The revitalization of the historic Budd plant is delivering a campus for science in all stages, from discovery to production. Both ready-to-go and future space for various lab services and biomanufacturing provide an epicenter for businesses to grow and evolve. The Budd Innovation Center, located at 2450 W Hunting Park Avenue offers fully built out, Class A working environments covering four floors and a fit-out ready Annex, meeting a variety of needs for life science users ranging from R&D, Lab, Incubator Space, Technical or Training Facilities, Vivarium, and Pilot Scale Manufacturing and up to Full-Scale Manufacturing. Across West Huntington Park Avenue, at 3431 Fox Street, space is immediately available for large-scale bioproduction within the Pioneer Building. An additional two buildings can support substantial future capacity at 3431 Fox Street under Phase 2 of the development. As a vibrant corner of industry and redevelopment, the Budd is a nexus to City Center Philadelphia and its surrounding suburbs. Easily accessible from Route 1 and Route 13, just a few blocks from SEPTA’s Allegheny Station, Budd also conveniently offers access to more than 700 free parking spaces on-site, the most abundant free office parking in the City of Philadelphia. Budd Bioworks is located 15 minutes to University City at the epicenter of “Cellicon Valley” and near esteemed college grounds, including Temple Hospital and Medical School, Thomas Jefferson University East Falls Campus, and Drexel University College of Medicine. Employees and visitors alike will enjoy nearby retail services, including ShopRite, Wendy's, Chipotle, T-Mobile, and recreational access at the adjacent Kroc Center. The campus is primed for occupancy to continue its legacy as a hub for innovation, boasting amenities including courtyard space, a fitness center, and conveniently placed bus stops surrounding the campus.

Date on Market:

2024-08-08

Philadelphia Office, Flex for Lease - Northeast Philadelphia

MaKen Studios South, located in Philadelphia’s historic industrial corridor, has been redeveloped for makers, artists, small manufacturers, and entrepreneurs. The building, once the Richardson Mint Co. and later the JoMar discount textiles retailer and warehouse, now serves as a modern hub for creative and light industrial activity under the direction of Shift Capital. The facility encompasses approximately 120,000 square feet and offers flexible studios ranging from 500 to 3,500 square feet, as well as an event space with the capacity for up to 500 guests. More than 100 tenants occupy the building, forming a collaborative environment that encourages creativity and business growth. MaKen Studios South provides thoughtfully designed spaces, a variety of leasing options, and an atmosphere intended to support innovation. Tenants at this location join a thriving community focused on helping their businesses flourish. Located just two blocks from the Tioga Station on the Market–Frankford Line, the property benefits from convenient transit access and IRMX zoning that supports a dynamic mix of uses. Located in the Kensington neighborhood, this property benefits from convenient amenities while also enjoying an artistic community atmosphere. In addition to its distinctive architectural appeal, 3525 I Street offers excellent access to local dining, retail options, and public transportation, facilitating effortless commutes and lunch breaks. The neighborhood offers many local spots surrounding the property, with big names just a quick drive away. The property is situated just two blocks from the Tioga Stop on the Market-Frankford El Line (an 18-minute ride to City Hall) and is only 10 minutes from the Allegheny Exit on Interstate 95.

Date on Market:

2025-08-05

Philadelphia Multiple Space Uses for Lease - Market Street West

1421 Race Street – Flexible Clinical, Lab & R&D Space in the Heart of Center City Race Street Labs | Philadelphia, PA Position your team at 1421 Race Street, home of Race Street Labs — a strategic life science and innovation hub in Center City Philadelphia. Just steps from major medical institutions and easily accessible from regional transit, the building offers a unique mix of clinical, lab, and flex/R&D space designed to support organizations at every stage of growth. Premium Lab Suites – Ready for Immediate Move-In Race Street Labs features a private full-floor lab suite engineered for biotechnology, microbiology, chemistry, and other advanced research operations. This move-in ready suite combines functionality, safety, and comfort to support serious science: Two 6-foot Venturi fume hoods Four lab sinks with gooseneck faucets and eyewash capability Three large lab islands with approximately 16 powered workstations Large open-concept team office plus two private executive offices Dedicated storage and IT/server rooms Two private restrooms within the suite Private kitchen and break area Emergency shower and eyewash station Automatic motion-sensor lighting Backup generator and dual 13,200V power feeds Lab HVAC exhaust system and circulating chilled water Freight elevator and loading dock access for equipment delivery On-site facility and lab management team This suite spans an entire floor, providing the security, exclusivity, and infrastructure required for focused research and innovation. Clinical & Medical Office Opportunities In addition to lab-ready space, 1421 Race Street offers unfinished clinical / medical office space on an upper floor that can be tailored to healthcare users. The open plan allows for customized layouts including exam rooms, consultation rooms, treatment areas, and administrative offices—ideal for medical practices, specialty clinics, or clinical support services seeking a modern, elevated setting in Center City. Flex & R&D Space An additional unfinished flex/R&D floor is available for teams that need adaptable space for: Research and development Product testing and prototyping Innovation labs or technical office use Hybrid lab/office or engineering environments The open, as-is layout provides the flexibility to design collaboration areas, workstations, labs, or light technical space around your specific operational requirements. Building Amenities Race Street Labs blends scientific performance with workplace comfort: Structured parking available within one block 24-hour keycard access Coffee bar and lounge area Large main-level conference room Indoor bike storage Ping pong and recreation area Virtual golf simulator Shower and locker facilities for tenant use Why 1421 Race Street Customizable environments for clinical, lab, and R&D users Robust infrastructure optimized for life science and innovation Flexible office and collaboration configurations On-site management and maintenance support Unbeatable Center City location in a growing biotech and healthcare corridor In addition to the move-in ready lab suite, additional lab and flex spaces are in development and can be built to tenant specifications — whether you need expanded wet lab capacity, specialized environments, or integrated office and collaboration zones. Schedule a private tour of 1421 Race Street to explore how our clinical, flex, and lab offerings can support your team’s next chapter of growth.

Date on Market:

2025-11-22

Philadelphia Office, Office/Medical for Lease - University City

CIC Philadelphia provides a dynamic and collaborative hub for entrepreneurs, startups, and enterprises in the heart of Philadelphia's University City. Located at 3675 Market Street, the property offers workspaces and labs with best-in-class services and amenities on flexible terms. Whether a small or large organization, fully in-person or hybrid, CIC Philadelphia delivers turnkey and tailored solutions. An ecosystem of entrepreneurs, scientists, venture capitalists, and innovators of all backgrounds awaits at CIC Philadelphia, with major tenants such as Amicus Therapeutics and the University City Science Center. Private and shared move-in-ready lab facilities, customizable private offices with a capacity for up to 50 people, and coworking desks with library-style seating are available to meet business needs immediately. Every CIC Philadelphia member can access stellar amenities, including concierge-level guest services, dedicated operational and technical support, fully equipped and stocked kitchens, video conference rooms, phone booths, printers, copiers, and more. Plus, members enjoy a series of regularly scheduled events, from networking to education and wellness. Completed in 2018, 3675 Market Street features an impressive lobby, an on-site café, a LEED Gold certification, and access to the Quorum, an expansive 15,000-square-foot events and conference center. Situated in the heart of Philadelphia's innovation district, the building is close to PENN Presbyterian Medical Center, Drexel University, and the Keystone Innovation Zone (KIZ). This prime location is only a block from the Route 10 Tramway, served by the Market-Frankford Line subway, and near an activated streetscape and a future public square. The surrounding area features over 250 restaurants, 10 farmers markets, over 700 hotel rooms, and abundant retail and entertainment options. Cambridge Innovation Center (CIC) is transforming how innovation happens. Since its founding in 1999, CIC has grown to host over 2,000 companies in seven cities throughout the United States and Europe. For over twenty years, CIC has built dynamic communities that empower founders to create companies and develop groundbreaking solutions.

Date on Market:

2023-03-31

Philadelphia Retail for Lease - University City

Situated directly across the Schuylkill River from Center City, University City is the easternmost portion of West Philadelphia, encompassing several Philadelphia universities. Home to the University of Pennsylvania, Drexel University, and the University City campus of Saint Joseph’s University. The Penn and Drexel campuses contain several medical institutions, independent centers of scientific research, and 30th Street Station, one of the nation’s busiest passenger train stations.

Property Type:

Multifamily

Date on Market:

2024-04-09

Philadelphia Office for Lease - Independence Hall

Designed, engineered and built to carry the weight and withstand vibrations of massive printing presses, the iconic Curtis is poised to become a world class conversion and meet the comprehensive space needs of the surging life science community. Located within America's most historic mile, this Philadelphia Landmark is as relevant today as it was the day it was built. No other building in Philadelphia can offer the base features required for speed to market, as can The Curtis. The Curtis has: 220 lb floor loads, dual 13,200 v electric feeds, back- up generators, excess shaft space for exhaust, circulating chilled water throughout, two (2) freight elevators 4,500 and 5,500 lbs capacity, four (4) fresh air intakes per floor, 12 story atrium providing double the amount of natural light, 14' 6'' ceiling heights and last but not least, is the permanent home of "The Dream Garden" the 100,000 piece glass mural designed by Mayfield Parrish and built by Tiffany Studios.

Date on Market:

2023-03-02

Philadelphia Office, Office/Medical for Lease - Market Street East

156,000 Square foot, 15 story office building in the heart of Center City with traditional, creative and medical office options available.

Date on Market:

2022-05-17

Philadelphia Office for Lease - University City

Property Type:

Specialty

Date on Market:

2025-10-23

Philadelphia Office for Lease - University City

Date on Market:

2025-08-22

Philadelphia Retail for Lease - University City

Property Type:

Hospitality

Date on Market:

2025-04-07

Philadelphia Office, Office/Medical for Lease - University City

Cira Centre, Brandywine Realty Trust’s 29-story flagship skyscraper, graces the west bank of the Schuylkill River and connects Philadelphia’s two primary economic districts: Center City and University City. Designed by Master Architect César Pelli, University City’s first office tower sets a precedence in location as well as architectural design. A signature transit-oriented development, Cira Centre is directly connected to Amtrak’s 30th Street Station – a primary hub for regional, multimodal transportation along America’s Northeast Corridor. At night, the building adds unique excitement to the city’s skyline with 1,500 decorative LED light fixtures programmed to showcase color-dazzling artistic, and community-driven light-shows. Exclusive tenant amenities include a private shuttle, fitness center, and world-class conference facilities. Iron Chef Jose Garces operates a fine dining establishment in the building’s lobby, which also hosts private event functions and wedding celebrations. Cira Centre’s esteemed tenant roster includes Dechert LLP, Essity North America, McKinsey & Company, and BlackRock.

Date on Market:

2025-08-04

Philadelphia Office for Lease - University City

Discover 3025 JFK Boulevard, the 28-story mixed-use West Tower of the iconic and innovative Schuylkill Yards neighborhood. West Tower tenants enjoy elevated work and life experiences within one address. 3025 JFK Boulevard delivers a mix of workspace, life science, retail, luxury residences, and an expansive indoor-outdoor amenity level in Philadelphia's most exciting new neighborhood, Schuylkill Yards. The building's upscale indoor and outdoor amenity spaces on the ninth floor are designed to bring luxury to the heart of University City. 3025 JFK Boulevard will feature a highly anticipated rooftop pool with a sundeck, cabanas, a large-format movie screen and landscaped terrace areas with pergolas, as well as a 14,500-square-foot highly amenitized lifestyle club with a coworking lounge with booths, a kitchenette, and conference and meeting rooms. A state-of-the-art fitness center with locker rooms and showers is also featured. Close to Amtrak's 30th Street Station, Interstate 76, and Interstate 676, 3025 JFK Boulevard offers unparalleled access, whether for pedestrians or by personal vehicle, mass transit, or bike. 3025 JFK Boulevard serves as the central connection point between Center City's economic district and University City's "eds and meds" epicenter, providing immediate connections to vibrant public spaces, lively retail and recreation options, and the region's top talent. Join the bustling Schuylkill neighborhood at the West Tower for a once-and-a-lifetime work and play experience.

Date on Market:

2024-03-04

Philadelphia Office/Medical for Lease - University City

Multifamily property with retail spaces on the lower levels. Unparalleled location just steps from UPenn and Drexel campuses and less than one mile from University of the Sciences. Walking distance to/from Penn Presbyterian, Hospital of the University of Pennsylvania(HUP), and Children’s Hospital of Philadelphia (CHOP).

Property Type:

Multifamily

Date on Market:

2023-11-09

Philadelphia Retail for Lease - University City

400,000 SF mixed-use office and lab building with ±20,000 SF ground floor retail space.

Property Type:

Office

Date on Market:

2023-03-21

Philadelphia Office, Retail for Lease - University City

Seated at the heart of Philadelphia’s life sciences community, 3201 Cuthbert is perfectly positioned and equipped to support discovery, collaboration, and innovation in the field, with the most robust life sciences infrastructure in the region.

Date on Market:

2023-03-21

Philadelphia Office for Lease - University City

3711 Market is a premier lab and office building designed to accomodate the needs of today's biotech and life science companies. 3711 Market is conveniently located at the heart of uCity Square, within walking distance of University City's world class Universities, Health Systems, and Research Institutes. 3711 Market is home to fast growing biotech companies, established pharmaceutical companies, and research groups developing the next generation of curative therapies. 3711 Market provides robust lab infrastructure in addition to a 500 Car Parking garage and retail amenities including Han Dynasty and Orange Theory Fitness.

Date on Market:

2023-08-10

Philadelphia Office for Lease - Market Street West

Date on Market:

2025-12-11

Philadelphia Retail for Lease - University City

4101 Market Street is in a QOZ & KOZ. Street Frontages: - 214’ on Market Street - 55’ on 42nd Street - 92’ on 41st Street With an expansive sidewalk/plaza area ranging from 10’ to 20’ on all perimeters of the building. Located in one of Philadelphia’s most thriving neighborhoods, home to a diverse community of college students, artists and families who live and work amid world-class universities, dining, retail and cultural offerings. Pedestrian and biker friendly with access to Market Street bike lane.

Property Type:

Office

Date on Market:

2024-11-21

Trevose Industrial for Lease - Lower Bucks County

Located in the Metropolitan Business Center, this 118,000-square-foot industrial distribution property is convenient to Route 1, PA Turnpike & Interstate 95.

Date on Market:

2025-11-21

Philadelphia Multiple Space Uses for Lease - University City

3440 Market Street is a six-story (6-story), 120,000-square-foot state-of-the- art wet and dry laboratory facility. This ?exible ?oorplate provides users with 10’ ?nished ceilings, the ability to plan their layout ef?ciently and an impressive window line for great natural light throughout. The building is designed to accommodate typical of?ce, clinical and lab uses. The 19,600 RSF ?oor plates, 14.8’ slab-to-slab - 10’ ?nished ceiling heights maximizes the amount of natural light throughout the structure. 3440 Market Street incorporates many energy saving features, state-of-the-art systems, sustainable design and construction practices, has ?ve levels of parking (500 spaces), and substantial city and state tax (KIZ/KOZ) bene?ts available. The building will incorporate many energy saving features, state-of-the-art systems, and sustainable design and construction practices. The building is designed to accommodate typical of?ce, clinical and lab uses.

Date on Market:

2025-10-23

Philadelphia Office for Lease - University City

3535 Market Street is an 18-story, Class-A office/Medical building located in downtown Philadelphia. It has terrific views of the city, continuous glass lines, large floor plates, and easy access to public transportation. Prominent location in the heart of the University City Science Center with proximity to the University of Pennsylvania, Drexel University, and Children's Hospital of Philadelphia

Date on Market:

2025-01-31

Philadelphia Office/Medical for Lease - University City

Proposed 400,000Sf office building.

Property Type:

Office

Date on Market:

2017-06-26