19 Life Science Properties for Lease in Somerville, MA, USA

Somerville Office for Lease - Somerville/Everett

74M is a breakthrough life science development in Somerville, Massachusetts. Currently, under construction, the 15-story purpose-built lab office building will contain 465,000 square feet of space. Through incorporating cutting-edge design, services, and amenities, 74M is the next life science development centered in the vibrant Somerville innovation community. Experience state-of-the-art labs that support mission-critical research and development. 74M is LEED Platinum, WELL Platinum, and WiredScore Platinum certified – meeting exceptional standards for infrastructure, energy efficiency, and tenant well-being. The building’s focus isn’t just on scientific advancements but also on the scientists who discover them. On-site amenities include an expansive rooftop lounge and event space featuring expansive skyline views, a well-being center featuring fitness and spa-style facilities, an expansive outdoor terrace, and more. 74M offers easy accessibility and unparalleled visibility directly adjacent to I-93 and a short walk to the MBTA Orange Line station. The development creates connectivity between the highly amenitized Assembly Square and the authentic cafes and restaurants of East Somerville. Enjoy unencumbered views of Boston, Cambridge, and the Mystic River throughout the workday and benefit from proximity to a highly educated and talented workforce. 74M is an ideal destination for today’s innovators within a 10-minute drive of Kendall Square and Logan International Airport.

Date on Market:

2024-03-28

Medford Office, Flex for Lease - Medford/Malden

This unique property, located off Boston Avenue, offers easy access to a diverse vibrant community known for its restaurants, shops, urban gardens, cutting-edge research and academic institutions, and numerous public transportation options. The building offers superior office and lab facilities with a unique, urban feel. Affordable offices while being close to both the suburbs and the city. Medford is home to Tufts University, and several other major academic institutions, Harvard and MIT are in proximity. Medford and Somerville are easily reached by public transportation and are just minutes from I-93.

Date on Market:

2025-04-07

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Choose a prime location in the heart of Cambridge, Massachusetts, with the contemporary office spaces available for lease at 1035 Cambridge Street. This versatile office building offers a unique blend of modern amenities and historic charm, making it an ideal location for businesses of all types. New tenants will be able to join a performing roster of technology, biotech, healthcare, real estate, architecture, coworking, and not-for-profit companies. The available suites at 1035 Cambridge Street come in a wide variety of sizes between 1,518 and 7,136 square feet, with flexible layouts and contemporary features. Most of the units are equipped with private offices, conference rooms, break areas, and open workspaces. Suites come in a variety of finishes, with carpeted or wood flooring, large windows, and attractive built-ins. Tenants at the property enjoy access to a shared conference center facility, common area bathrooms with showers, and abundant on-site parking for 150 vehicles. 1035 Cambridge Street was originally built in 1930 and extensively renovated over the years, spanning a total of 99,500 square feet across three floors. The building’s spacious lobby enters a dramatic two-story atrium with an impressive, oversized skylight and brick and beam finishes, creating a welcoming atmosphere for clients and employees. Tenants have 24/7 access to the property, with card readers and video cameras for security. Centrally located at the heart of Cambridge, 1035 Cambridge Street situates tenants within an established hub near a wealth of quality urban amenities. The location is just a third of a mile from Union Square and Inman Square, both major commercial centers of the region with excellent restaurants and specialty stores. Offering convenient accessibility for commuters, the property sits just a short distance from major highways, including Highway 28 and Interstate 93. Providing additional access options, the site is a short walk from the Union Station Green Line stop, as well as several bus stops, and there are Zipcars and Hubway bikes on-site. Situated approximately 1 mile from both Harvard University and the Massachusetts Institute of Technology, businesses at 1035 Cambridge Street have access to one of the nation’s strongest talent pipelines, which can fuel future growth and expansion. When looking within just 1 mile of the property, tenants can tap into a sizable workforce of more than 68,000, with over 70% of locals carrying a bachelor’s degree or higher. Unlock premier office space at 1035 Cambridge Street, combining modern amenities, flexible layouts, and an unbeatable Cambridge location, with access to top talent, transportation, and vibrant commercial centers. Reach out to the Lee & Associates team today to schedule a tour and find the perfect space.

Date on Market:

2025-11-28

Charlestown Office, Industrial for Lease - Charlestown/East Boston

500 Rutherford Avenue, situated within the Hood Park 20-acre mixed-use urban campus, is a beautifully renovated three-story facility in Charlestown, Massachusetts. Presenting approximately 125,000 square feet of new construction, the 300,000-square-foot building has been re-adapted to serve a diverse user base. Tenants experience a dynamic setting with abundant on-site parking, efficient floor plans, a private lounge area, and high-visibility signage potential. Current availability includes first-generation research and development (R&D), lab, and manufacturing space. Tenants benefit from ample 1,200-amp, 480-volt power and a fully furnished leasing opportunity with office and lab equipment included. There’s also an additional 6,000 square feet of open warehouse/industrial space with a 16-foot clear height that can easily be brought up to code for a variety of uses. Plus, the potential to tie into RODI (Reverse Osmosis Deionization) and pH neutralization systems are available. 500 Rutherford Avenue offers a vibrant and well-connected setting for modern businesses. Tenants enjoy convenient Hood Park amenities like Tradesman Coffee Shop & Pizza Bar, Urban Wild live music venue, Element Salon and Spa, and Hotbox by The Handle Bar fitness studio. The property offers direct Interstate 93 connectivity for swift travel to Downtown Boston and is close to the North Station and Assembly Row commercial hubs. For added convenience, tenants benefit from electric vehicle charging stations and shuttle service to nearby MBTA stations. Combining cutting-edge facilities with desirable amenities, 500 Rutherford Avenue offers an ideal location for businesses seeking a seamless work-life balance.

Date on Market:

2024-11-12

Cambridge Flex for Lease - E Cambridge/Kendall Sq

Brokers Welcome! A clean and well-maintained, privately owned building in the vibrant East Cambridge neighborhood with close proximity to public transportation, Kendall Square and Route 93. Lechmere station is just 7 minutes away on foot, or take the on-site #69 MBTA bus toward Lechmere or Harvard Squares. Great restaurants, coffee shops, markets and grocery stores all within walking distance. Currently 1 Unit Available on November 1, 2025 which includes 4033 Suite B1 and 689 SF Suite 102 ($22.50 NNN + $7.50): Cambridge is finally affordable again! A rare, flexible, low-cost, grandfathered distribution/tech/light manufacturing/contractor/storage/R&D/repair/lab space with plenty of office/desk & conference space in the heart of a dynamic East Cambridge neighborhood. 800 amp, 3-phase 208V electrical service. A dedicated, 6500 lb material lift with 4’ x 8’ car, features a straight shot from the parking/loading area through the 689 sf first floor office space, and down to the lower level’s 4033 sf flex space. Includes 2 lab sinks, kitchen/break room, 3 different HVAC systems with app control. Private restroom with private shower included. First floor features a dedicated office and open conference room space with giant, south-facing windows. Lower level features new, epoxy flooring throughout. Wired networking capable of 10GB and rack space available. Up to 6 parking spaces are available for an additional fee. 24 hour, swipe/prox card secure access. Starter workstations and tables shown in photos may be included as desired. The combined 4722 sf space comes as a single, indivisible unit.

Property Type:

Office

Date on Market:

2025-07-10

Cambridge Retail for Lease - Mid-Cambridge/Harvard Sq

This fully equipped restaurant and bar includes 40 beer taps, a beer cooler with storage for 40 kegs, high-speed kiddie exhaust system,and a grease trap. A complete list of equipment is available upon request Storage:The facility has a walk-in refrigerator and freezer located in the basement. *Liquor License: Full liquor license issued by the City of Cambridge. Seating Capacity: The establishment can accommodate 99 diners plus bar seating Location: The restaurant is located in the Restaurant Hub of Cambridge, specifically in Inman Square, which is in close proximity to MIT and Harvard University. Nearby Amenities and Restaurants: - Christina’s Homemade Ice Cream - All Star Sandwich Bar - All Star Pizza Bar - Inman Square Wine & Spirits - Casa Portugal Restaurant - Puritan Oyster Bar - Oak Bistro - Christina’s Spice & Specialty Foods - East Cambridge Savings Bank - The Druid - CHA Cambridge Hospital - And many more. **Operational History:** The property has been grandfathered as a restaurant since 1986. Parking: There are 4 on-site parking spaces available, with additional parking options nearby after 5:00 PM. Loading Area: The loading area is located in the parking lot. Traffic Count: Approximately 22,358 vehicles pass through the intersection of Cambridge and Prospect Streets daily. **Utilities: The property has separately metered utilities for electricity, water, and gas. Water & Sewer Services: These services are provided by the City of Cambridge.

Date on Market:

2025-01-24

Cambridge Flex for Lease - E Cambridge/Kendall Sq

In 2021, Ownership completed a new façade on the building with the intention of completing the Lobby Renovation Project in Summer 2022. The Lobby Renovation will include a new at-grade accessible entrance, new freight elevator and stair column with access to the roof and a newly accessible Tenant Opportunity. This is the ideal time to coordinate with our Contractor to deliver your ideal lab space to Kendall Square.

Property Type:

Industrial

Date on Market:

2022-07-18

Charlestown Flex for Lease - Charlestown/East Boston

Brand New Lab, Heavy R&D, and Clean Room space with ability to modify as needed. Heavy Power, Loading, and other infrastructure available. Perfect space for Light Manufacturing, Electronics, Clean Room, and Advanced Manufacturing Groups.

Date on Market:

2025-05-12

Medford Office/Medical for Lease - Medford/Malden

One Cabot Road is a four story, ±316,233 SF class A office building located in the thriving community of Medford, Massachusetts. The property recently underwent a $16.9 million amenity upgrade and now features a new lobby lounge, coffee lounge, new fitness center and locker rooms, expansive outdoor patio and a full-service cafe.

Property Type:

Office

Date on Market:

2024-02-23

Cambridge Office, Flex for Lease - Mid-Cambridge/Harvard Sq

Date on Market:

2025-09-29

Charlestown Multiple Space Uses for Lease - Charlestown/East Boston

Date on Market:

2025-06-05

Medford Flex for Lease - Somerville/Everett

The property is an office building occupying 37,717 square feet. There are four floors and the building was built in 1940 with a renovation in 1994.

Property Type:

Office

Date on Market:

2025-01-24

Somerville Flex for Lease - Somerville/Everett

599 Somerville Ave is an expansion of Somernova, located a few short blocks from the main campus. This project offers lab, flex, and office spaces with optional turn-key buildouts. Ideal for diverse businesses seeking innovation and collaboration in a dynamic community.

Date on Market:

2023-11-07

Somerville Office for Lease - Somerville/Everett

101 South Street is speculative lab building in the Boynton Yards industrial area of Somerville, MA. Located adjacent to Union Square and only one mile from Kendall Square, the City of Somerville plans for Boynton Yards to be redeveloped into a vibrant, mixed-use district comprised of lab, office, multifamily and neighborhood retail and community arts space.

Date on Market:

2025-04-03

Medford Office for Lease - Medford/Malden

Property Type:

Flex

Date on Market:

2024-05-08

Cambridge Office for Lease - E Cambridge/Kendall Sq

Date on Market:

2024-04-15

Cambridge Flex for Lease - W Cambridge/Alewife

Date on Market:

2023-02-02

Cambridge Office for Lease - E Cambridge/Kendall Sq

Date on Market:

2022-07-18

Cambridge Office for Lease - E Cambridge/Kendall Sq

Date on Market:

2023-01-13