25 Life Science Properties for Lease in South San Francisco, CA, USA

South San Francisco Flex for Lease

Southline is an innovative, 31-acre purpose-built science and technology development in South San Francisco, conveniently located directly adjacent to BART and within walking distance to Caltrain. The campus will feature 2.8 million square feet of Class A office and life science space, offering an authentic work-life experience in one of the most exciting developing neighborhoods in the Bay Area. With modern innovation in mind, Southline offers expansive, flexible floor plates ranging from 50,000 to 100,000 square feet of office space. Up to 65,000 square feet is dedicated to life science use. Office ceiling heights of 16 feet on the ground floor and 14 feet on the upper levels provide a spacious, open feel. Life science areas feature 16 to 18 feet of clearance, accommodating high-capacity storage and specialized equipment. Generous 30- to 33-foot column spacing, a strong live load capacity of approximately 125 pounds per square foot, and 8,000 MIPs ensure the project is equipped to support even the most demanding operations. Designed for innovation, inside out, Southline has curated amenities, restaurants, and retail that give big ideas space to grow, offering structure for deep thinking and space for spontaneity. The mass timber dedicated amenity building brings to the campus a fitness and wellness center, a coffee bar and grab-n-go food options, a conference center, outdoor seating areas, a well-appointed walking trail, a fruit and veggie garden, a campus Caltrain shuttle, a designated rideshare area, and a bike barn with a repair desk. A beer garden, fire pits, food truck court, outdoor collaboration areas, games and activities, and the Southline Commons (a 2-acre open space) are included in Phase 2, coming soon. Situated at the intersection of 101, 380, and 280, where BART and Caltrain converge and just minutes from San Francisco International Airport (SFO), the entire Bay Area is as accessible as it has ever been at Southline. Over 2,300 housing units are within a short walk of this project. All this and more provides the opportunity to recruit and retain from everywhere. Southline is in the center of Lindenville, a burgeoning, mixed-use neighborhood that soon will become an employment hub and the cultural heart of South San Francisco. In addition, it is across the street from a planned new 400,000 square foot retail village at Tanforan, including restaurants, cafes, Target, and a cinema. This growing area will offer a walkable live/work community, creating opportunities to shape South San Francisco's next chapter. South San Francisco has a rich history of pioneering industry and seamlessly bridges the innovative spirit of San Francisco with the technological prowess of Silicon Valley. At Southline, inspiration is tradition, and the Industrial City will give birth to the next phase of creative thinkers, disruptors, and pioneers fueled by the energy of its surroundings.

Date on Market:

2024-07-17

South San Francisco Office, Flex for Lease

Gateway of Pacific (GOP) is a landmark, delivering premier laboratory and office space at the front door to South San Francisco’s flourishing biotechnology community. This fully integrated campus is designed to the highest institutional standards, featuring distinct and robust buildings within an active, urban-park-like setting. Gateway of Pacific encapsulates a vibrant, amenity-rich campus setting. The campus' central park is a zen-like environment for connection and collaboration outside the office or laboratory. The premium conference center, Forum, is a 20,000-square-foot exceptional meeting and gathering space that can accommodate up to 450 guests. At the heart of the campus is TRAVERSE, a state-of-the-art amenity center that offers a personalized array of culinary, fitness, and community experiences that empower moments of connection and collaboration. Placing health and wellness at the center of building design, Gateway of Pacific incorporates sustainability features, including on-site generation, rainwater capture, greywater collection, high-efficiency HVAC systems, and electric vehicle infrastructure. Gateway of Pacific I and Traverse have achieved LEED Platinum certification, and all other buildings are targeting either LEED Gold or Silver certification. Anchoring the entrance to South San Francisco at Oyster Point Boulevard, Gateway of Pacific is a highly visible project in a top-tier destination in the Bay Area. South San Francisco is the birthplace of biotechnology with one of the largest biotech clusters in the world, with over 200 world-class life science companies, a vast network of venture capital, and access to the nation’s premier life sciences workforce, drawing from nearby UCSF, UC Berkeley, and Stanford University.

Date on Market:

2026-05-18

South San Francisco Industrial for Lease

Experience logistics simplified at our South San Francisco Harris location. This flexible warehouse space features all the amenities your business needs to thrive, with units ranging from small to large configurations to accommodate businesses of all sizes. Strategically positioned with easy access to major transportation networks including I-101, I-280, and I-380, this location is just 5 minutes from San Francisco International Airport (SFO) and offers excellent proximity to Caltrain. Security and convenience come standard with 24/7 facility access, private secure units, well-lit pathways, building access control, video surveillance, and comprehensive visitor management systems.

Date on Market:

2021-03-11

South San Francisco Industrial for Lease

250 Hillside Blvd offers a ±29,800 SF freestanding industrial building designed for clean technology, manufacturing, or advanced production. The property combines high-capacity infrastructure with modern features, including a fully improved office and lab area of approximately 8,500 SF. This single-tenant facility offers the flexibility to accommodate a range of industrial operations, supported by robust power and efficient loading capabilities.

Date on Market:

2026-02-11

South San Francisco Office, Flex for Lease

This freestanding office and warehouse property offers a unique opportunity for tenants seeking flexibility and advanced infrastructure in South San Francisco’s growing life science and technology corridor. The building spans approximately 40,606 square feet, including a newly built-out office component with high-end finishes, a remodeled lobby, and functional common spaces. Designed for modern occupiers, the property features an advanced HVAC system with dedicated outside air and MERV 13 filters, individual suite thermostats, and zoned air handling to ensure optimal indoor conditions. The warehouse portion offers approximately 19,798 SF with 22-24 foot clear heights, supported by generous 1,600A / 3-phase power to accommodate specialized or high-intensity operations. Enhanced security is provided through monitored systems and controlled access points. Located within the South San Francisco life science cluster, the property offers immediate access to US-101, with close proximity to major transportation nodes including Caltrain, BART, and the South San Francisco Ferry Terminal. Tenants will benefit from nearby amenities such as The Shops at Tanforan, numerous dining options, and proximity to global biotech leaders like Genentech. Parking is ample with 102 dedicated spaces.

Date on Market:

2017-11-16

South San Francisco Office, Flex for Lease

468 Littlefield Avenue presents a rare opportunity to lease a full-building life science, research and development, or office facility in South San Francisco, one of the Bay Area's most established biotechnology and innovation corridors. The property consists of approximately 44,311 square feet across three levels and offers flexibility for a wide range of occupiers seeking laboratory support, research operations, office headquarters, or technology-focused workspace. The building is offered with most equipment removed and is positioned as a tenant-improvement-ready opportunity, allowing users to customize the environment to meet operational requirements. Existing infrastructure includes substantial electrical capacity with a current 900-amp service supported by a 750 KVA transformer, along with PG&E-approved capacity for future expansion to 3,000 amps. Building systems include multiple boilers, chillers, air handling units, and exhaust systems that support demanding operational requirements. The location provides convenient regional connectivity with immediate access to Highway 101, proximity to Highway 280 and Highway 380, and access to Caltrain, ferry service, and San Francisco International Airport. Occupiers benefit from nearby restaurants, hotels, recreation amenities, and services throughout South San Francisco's Oyster Point and Lindenville districts. The property's combination of infrastructure, flexibility, transportation access, and positioning within a recognized life science market makes it well suited for organizations seeking a strategic Bay Area presence.

Date on Market:

2026-07-29

South San Francisco Office for Lease

Designed for growing life science companies, our plug-and-play workspace enables your team to begin operations immediately, eliminating the time, cost, and disruption associated with traditional lab and office build-outs. Preserve valuable capital for research, hiring, and product development while benefiting from flexible lease terms and customizable rent structures that can evolve alongside your business. Whether you're advancing through critical R&D milestones, expanding your team, or preparing for your next funding round, you'll have the certainty of the space you need today with the flexibility to accommodate tomorrow's growth.

Date on Market:

2026-07-21

South San Francisco Office for Lease

Excellent office sublease with water views. 3 private offices, open space, and shared conference room and shared kitchen

Date on Market:

2026-06-08

South San Francisco Office for Lease

480 Forbes Blvd is a five-story laboratory and office building located within the Vantage life science campus in South San Francisco, California. The property contains approximately 154,000 square feet and is situated on a campus designed to support life science, biotechnology, and research users. Building features include floor-to-ceiling windows, structured and surface parking, laboratory-capable infrastructure, and access to a shared amenity center. The property is located within South San Francisco's biotechnology corridor near major transportation routes, employment centers, and life science research facilities.

Property Type:

Flex

Date on Market:

2026-06-03

Brisbane Office for Lease - Brisbane/Daly City

Date on Market:

2026-03-05

South San Francisco Industrial for Lease

The warehouse features a minimum clear height of approximately 21 feet, multi-ton HVAC capability, and a robust 2,000-amp, 277/480-volt power supply suitable for power-intensive processes. Efficient logistics are supported by three dock-high loading positions and three drive-in loading points, ensuring seamless inbound and outbound movement. The site spans roughly 9.8 acres and provides a generous parking ratio, improving flow and convenience for teams and fleet vehicles alike.

Date on Market:

2026-02-20

Brisbane Office for Lease - Brisbane/Daly City

1800 Sierra Point 2nd floor office space. New office build out. Located in the center of the Bay Area life science cluster.

Date on Market:

2026-01-07

South San Francisco Office for Lease

650 Gateway Blvd South San Francisco, CA R&D building with ample lab space.

Date on Market:

2025-12-09

Brisbane Office for Lease - Brisbane/Daly City

Strategically positioned along Highway 101 with massive freeway signage, the building provides exceptional identity and accessibility. Tenants benefit from a robust infrastructure, including 4000A normal power, a 1250kW generator, 200kVA UPS, and EV charging stations. Shuttle service to Caltrain and BART ensures seamless connectivity to the broader Bay Area, while on-site amenities such as a fitness center, wellness rooms, and café foster a dynamic work environment. Located just 12 minutes from downtown San Francisco, 7000 Marina Blvd offers proximity to major biotech clusters, top-tier dining, and hospitality options. With panoramic Bay views and direct access to the Bay Trail, this property delivers a rare combination of technical sophistication and lifestyle appeal—ideal for companies seeking a flagship presence in one of the nation’s most vibrant life science markets.

Date on Market:

2025-10-27

South San Francisco Flex for Lease

Join a premier life science campus with the versatile spec suites available for lease at East Grand Avenue in South San Francisco, California. Coming available in September of 2026, these modern spaces include options for 22,250 and 37,532 square feet, offering an ideal canvas for growing teams and institutional businesses. This incredible business destination offers a range of exceptional on-site amenities that form an idyllic and energizing hub for corporate activity. Tenants enjoy access to an activated wellness center, a restaurant, sports courts, and a 300-person conferencing center. There is also abundant on-site parking available with EV charging stations, as well as generous outdoor space with outdoor walking trails and lush landscaping. Situated in a prominent location close to the Highway 101 interchange, this rare offer places businesses in an easily accessible commercial hub. The campus is just a short walk to the SSF Caltrain station, and less than 10 minutes from SFO airport. The surrounding area presents a wide array of desirable urban amenities, including top-rated shopping, dining, recreation, and hotels.

Date on Market:

2026-05-12

South San Francisco Office for Lease

Property Type:

Flex

Date on Market:

2025-02-04

South San Francisco Flex for Lease

±14,943 SF life science availability located in Edgewater Science Park. Building amenities include on-site café and access to walking and hiking trails on the San Francisco Bay Trail.

Date on Market:

2026-02-27

South San Francisco Flex for Lease - Brisbane/Daly City

Built for laboratory research and dedicated to best-in-class biotechnology. Prime location within the South San Francisco life sciences cluster and excellent access to Highway 101.

Property Type:

Office

Date on Market:

2026-05-06

South San Francisco Flex for Lease

The location offers exceptional accessibility via Highway 101 and multiple transit connections. The campus is within walking distance to the South San Francisco Caltrain station and features dedicated shuttle services to BART and ferry terminals. Surrounded by a strong amenity base, including a variety of dining, fitness, and childcare options, the campus ensures convenience for employees. Positioned just minutes from San Francisco International Airport and biotech corridor resources, 600/650 Gateway Boulevard is a top-tier selection for cutting-edge innovators seeking a highly connected and future-ready setting.

Date on Market:

2026-07-27

South San Francisco Office for Lease

7000 Shoreline Court is a waterfront life science and office property located in the Oyster Point area of South San Francisco. The building includes lab and office space, loading dock access, and outdoor amenities. It is situated near Highway 101 with connectivity to San Francisco International Airport and downtown San Francisco. The property offers on-site parking with EV charging stations and is adjacent to the Bay Trail.

Date on Market:

2025-11-21

Brisbane Office, Flex for Lease - Brisbane/Daly City

The Towers at Sierra Point is a two building ±450,187 Sq. Ft. Class A office and lab campus located along the waterfront in Brisbane.

Date on Market:

2026-02-06

South San Francisco Office for Lease - Brisbane/Daly City

5000 Shoreline is centrally located in the heart of Biotech in South San Francisco. The Bay Area boasts the largest concentration of life science companies in the world and is a hub for both scientific and technological research and development

Date on Market:

2023-02-03

Brisbane Office for Lease - Brisbane/Daly City

The Shore at Sierra Point consists of 5 buildings with all the modern-day features businesses demand. Located in Brisbane, California. This LEED pre-certified campus offers bay-front walkways, ample green space, retail and dining within walking distance.

Date on Market:

2023-03-20

South San Francisco Flex for Lease

Kilroy Oyster Point Phase 2 is now delivering: three state-of-the-art buildings totaling approximately 865,000 square feet in the heart of South San Francisco—the birthplace of biotechnology. Kilroy Oyster Point Phase 2 is a premier waterfront life sciences environment designed to accelerate scientific innovation within one of the Bay Area’s most established biotech clusters. Set along Oyster Point’s shoreline, the campus blends purpose-built lab and office buildings with expansive outdoor zones, providing an energized setting that supports collaboration, wellness, and productivity. Tenants benefit from next-generation infrastructure including significant floor load capacities, large open floor plates, and LEED Gold–targeted design, all arranged within an interconnected outdoor village featuring amphitheater seating, a conference center, fitness amenities, and Farewinds restaurant and café. The location offers both inspiration and convenience, just steps from beaches, trails, hotels, and immediate access to ferry service and major freeways, making Phase 2 a destination for companies seeking an elevated, amenity-driven research workplace.

Date on Market:

2026-08-24