12 Life Science Properties for Lease in Worcester, MA, USA

Worcester Multiple Space Uses for Lease - Worcester Metro

Date on Market:

2026-04-03

Worcester Flex for Lease - Worcester Metro

Prime Downtown Worcester Retail/Office Space – 1,900 SF | Move-In Ready Position your business for success in one of Worcester’s most visible and accessible locations. This 1,900 SF space sits in a high-traffic plaza with over 20,000 vehicles passing daily, just minutes from I-290 and I-190. Surrounded by major institutions including UMass Memorial, Saint Vincent’s, WPI, and the Biotech Park, this site offers unmatched proximity to healthcare, education, and innovation hubs. Property Highlights: • ?? Free on-site parking + direct bus stop access • ?? High-speed internet, central A/C, and affordable gas heat • ? Three-phase power, city water/sewer, and illuminated signage • ?? Near O’Connell Park and scenic wetlands • ?? Ideal for medical, wellness, office, or retail use Join a thriving mix of successful businesses in a plaza designed for visibility and convenience. The space is fully built out, move-in ready, and available immediately. ?? Contact Justine Snyder at 508-614-8258 to schedule a private tour and explore how this location can elevate your brand.

Date on Market:

2026-02-18

Worcester Office for Lease - Worcester Metro

Situated in the heart of Worcester's Gateway Park, 85 Prescott Street offers an unparalleled setting for businesses seeking to foster innovation, collaboration, and growth. With notable neighbors within walking distance such as WPI (A top STEM university solving real-world problems through hands-on projects and global engagement) and Massachusetts Biotech Initiatives (the longest-running life sciences incubator in the Commonwealth), as well as its proximity to all major highways and retail amenities, 85 Prescott Street is an ideal location for any business looking to grow with the city of Worcester. Join a community-hub, housing tenants such as the Massachusetts Academy of Math and Science at WPI, WPI Robotics Engineering, WPI University Advancement and the Research Solutions Institute, as well as many other medical and professional offices.

Date on Market:

2026-03-27

Leicester Multiple Space Uses for Lease - Outlying Worcester

75,000 +- SF former industrial mill building on a major east-west corridor in Worcester County. Highly visible and easily accessible for various uses, including office, retail, and distribution. Sub dividable space; available SF between 500 - 75,000, competitive rates, flexible lease terms, ample acreage for truck access, and potential truck offloading. Located on Route 9 in the Cherry Valley section of Leicester, MA, just over the Worcester City Line.

Date on Market:

2025-12-01

Worcester Office/Medical for Lease - Worcester Metro

Kelleher & Sadowsky is pleased to present 7,250 RSF - 33,000 RSF of high-quality office space available immediately for sublease at 306 Belmont Street in Worcester, MA. Formerly occupied by UMass Memorial Health, the space is in excellent condition and features a versatile layout that includes a mix of private offices, open work areas, training and conference rooms, and access to building amenities. Select furnishings may be available as part of the sublease. Ideally situated on Route 9 with quick access to I-290, 306 Belmont Street offers exceptional connectivity to the region’s colleges, hospitals, and surrounding com-munities. The property is located directly across from UMass Memorial’s University Campus, AbbVie’s bio-research facility, and The Reactory — Worcester’s rapidly developing biotech park. Don’t miss the opportunity to establish your presence in the heart of Worcester’s thriving life sciences and bio-tech corridor. Contact us today to schedule a tour.

Property Type:

Office

Date on Market:

2023-09-18

Worcester Retail for Lease - Worcester Metro

Date on Market:

2025-04-01

Worcester Office for Lease - Worcester Metro

One Innovation Drive is a four-story office/laboratory facility with an adjacent single-story parking structure and is known as Building 3 in the UMass Medical & Science Park. Situated alongside the continuously growing UMass Chan Medical School and UMass Memorial Medical Center campus, the UMass Medicine Science Park both contributes to and benefits from the organic synergies created within this interconnected complex. A palpable energy from an unparalleled 10,000+ knowledge seekers on site – in addition to approximately 10 additional neighboring colleges and universities – permeates the campus, encouraging innovative thoughts and collaborative partnerships.

Date on Market:

2025-04-01

Worcester Office for Lease - Worcester Metro

Situated on the bustling UMass Chan Medical School Campus, 403 Belmont Street is a state-of-the art medical facility boasting approximately 108,750 +/- SF of rentable area on 4 floors. The building includes an attached garage with a covered walkway connected to the 3rd floor, allowing for seamless patient and employee access. Ratio for parking is 4 / 1,000 SF. Tenants of 403 Belmont Street have access to the cafe and fitness center, located at the Albert Sherman Center. The Veteran Affairs (VA) outpatient clinic of Worcester occupies more than 50,000 SF within the Class A medical office building. The outpatient clinic offers primary care and specialty health services including laboratory services, physical therapy, nutrition counseling, radiology, and more. At 403 Belmont Street, 38,646 +/- SF remain available for lease on two floors, which can be subdivided to accommodate tenants from 5K SF and above. The space is ideal for vibrant medical practices looking to grow and expand.

Date on Market:

2022-10-21

Worcester Office for Lease - Worcester Metro

UMass Medicine Science Park is one of the nation’s leading centers for biotechnology research and production, providing a nurturing environment for companies during all stages of growth. Ranging from start-up incubator space to full-building footprints, the five-building park accommodates a variety of quality office and laboratory tenants within an extraordinary 10-acre campus setting. The nearly 470,000-square-foot park is home to dozens of biotechnology companies, as well as several non-profit and academic institutions. Situated alongside the continuously growing UMass Medical School and UMass Memorial Medical Center campus, the UMass Medicine Science Park both contributes to and benefits from the organic synergies created within this interconnected complex. A palpable energy from an unparalleled 10,000+ knowledge seekers on site – in addition to approximately 10 additional neighboring colleges and universities – permeates the campus, encouraging innovative thoughts and collaborative partnerships. Situated on a scenic green hilltop, UMass Medicine Science Park’s collaborative, campus setting offers tenants cutting-edge resources and ample amenities. Conveniences include: • Campus cafeteria • Campus fitness center • Plantation Street parking garage • UMass Medical School Library • Conference facilities • Beechwood Hotel & Conference Center (adjacent) • Access to Research Core facilities

Date on Market:

2024-07-15

Worcester Flex for Lease - Worcester Metro

20 Reactory Drive and 30 Reactory Drive are adjacent lots with permits in place. By combining these two parcels, The Reactory can accommodate from 95,000 to 380,000 square feet with parking on the combined lots. This allows for companies to design and construct a facility that meets their needs today and expansion for future growth. 31 Reactory Drive is the largest parcel on the campus. With over 24 acres of land, this site can accommodate a large-scale operation in one or multiple buildings. This is an ideal site for those companies that need significant size to start but even more for their growth in the future. With endless flexibility, The Reactory offers companies the ability to scale its operations as their business evolves. • 46 acre life sciences campus • 3 land parcels that can be subdivided or combined • Site can accomodate 70,000 square feet to over 1,000,000 square feet • Permits in hand • Foundation in place at 20 Reactory Drive • 100% support from The Commonwealth of Massachusetts and the City of Worcester • A proven location for Life Sciences Grow with us. Let The Reactory in Worcester be your next move.

Date on Market:

2024-02-29

Worcester Office for Lease - Worcester Metro

55 Union Street is strategically located within walking distance of the amenity-packed Downtown Worcester area.

Date on Market:

2025-02-14

Grafton Flex for Lease - The Boroughs

The first phase of Grafton Science Park is a new 348,000 square foot lab, research and office development on Tufts University’s Cummings School of Veterinary Medicine Grafton campus. The unique build-to-suit project reflects Tufts stature as a world class institution committed to sustainable development. Grafton Science Park sits on a 100-acre site on Route 30, on the western edge of the school’s expansive 594-acre campus abutting the Grafton MBTA commuter rail station. The approved master plan accommodates up to 702,000 square feet in three-story buildings, allowing for complete flexibility in actual building sizes and site areas. All major permits are in place. Construction of infrastructure and public utilities is complete. Occupants of the park will be on the campus of New England’s only veterinary school, in an enriching environment surrounded by Tufts’ world class faculty, students, and translational research. On-site amenities include a full service cafeteria, fitness center, and shared conference facilities. Worcester County has evolved into a growing, active area for technology, life sciences and innovation. The park is within an Economic Target Area. It is convenient to Worcester Polytechnic Institute, the University of Massachusetts Medical School, and leading life science companies throughout the I-495 and the Metrowest region. Pad ready sites are ready to be customized to your company’s needs.

Date on Market:

2013-06-13