34 Life Science Properties for Lease in Boston, MA, USA

Somerville Office for Lease - Somerville/Everett

74M is a breakthrough life science development in Somerville, Massachusetts. Currently, under construction, the 15-story purpose-built lab office building will contain 465,000 square feet of space. Through incorporating cutting-edge design, services, and amenities, 74M is the next life science development centered in the vibrant Somerville innovation community. Experience state-of-the-art labs that support mission-critical research and development. 74M is LEED Platinum, WELL Platinum, and WiredScore Platinum certified – meeting exceptional standards for infrastructure, energy efficiency, and tenant well-being. The building’s focus isn’t just on scientific advancements but also on the scientists who discover them. On-site amenities include an expansive rooftop lounge and event space featuring expansive skyline views, a well-being center featuring fitness and spa-style facilities, an expansive outdoor terrace, and more. 74M offers easy accessibility and unparalleled visibility directly adjacent to I-93 and a short walk to the MBTA Orange Line station. The development creates connectivity between the highly amenitized Assembly Square and the authentic cafes and restaurants of East Somerville. Enjoy unencumbered views of Boston, Cambridge, and the Mystic River throughout the workday and benefit from proximity to a highly educated and talented workforce. 74M is an ideal destination for today’s innovators within a 10-minute drive of Kendall Square and Logan International Airport.

Date on Market:

2024-03-28

Charlestown Office, Industrial for Lease - Charlestown/East Boston

500 Rutherford Avenue, situated within the Hood Park 20-acre mixed-use urban campus, is a beautifully renovated three-story facility in Charlestown, Massachusetts. Presenting approximately 125,000 square feet of new construction, the 300,000-square-foot building has been re-adapted to serve a diverse user base. Tenants experience a dynamic setting with abundant on-site parking, efficient floor plans, a private lounge area, and high-visibility signage potential. Current availability includes first-generation research and development (R&D), lab, and manufacturing space. Tenants benefit from ample 1,200-amp, 480-volt power and a fully furnished leasing opportunity with office and lab equipment included. There’s also an additional 6,000 square feet of open warehouse/industrial space with a 16-foot clear height that can easily be brought up to code for a variety of uses. Plus, the potential to tie into RODI (Reverse Osmosis Deionization) and pH neutralization systems are available. 500 Rutherford Avenue offers a vibrant and well-connected setting for modern businesses. Tenants enjoy convenient Hood Park amenities like Tradesman Coffee Shop & Pizza Bar, Urban Wild live music venue, Element Salon and Spa, and Hotbox by The Handle Bar fitness studio. The property offers direct Interstate 93 connectivity for swift travel to Downtown Boston and is close to the North Station and Assembly Row commercial hubs. For added convenience, tenants benefit from electric vehicle charging stations and shuttle service to nearby MBTA stations. Combining cutting-edge facilities with desirable amenities, 500 Rutherford Avenue offers an ideal location for businesses seeking a seamless work-life balance.

Date on Market:

2024-11-12

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

Choose a prime location in the heart of Cambridge, Massachusetts, with the contemporary office spaces available for lease at 1035 Cambridge Street. This versatile office building offers a unique blend of modern amenities and historic charm, making it an ideal location for businesses of all types. New tenants will be able to join a performing roster of technology, biotech, healthcare, real estate, architecture, coworking, and not-for-profit companies. The available suites at 1035 Cambridge Street come in a wide variety of sizes between 1,343 and 7,136 square feet, with flexible layouts and contemporary features. Most of the units are equipped with private offices, conference rooms, break areas, and open workspaces. Suites come in a variety of finishes, with carpeted or wood flooring, large windows, and attractive built-ins. Tenants at the property enjoy access to a shared conference center facility, common area bathrooms with showers, and abundant on-site parking for 150 vehicles. 1035 Cambridge Street was originally built in 1930 and extensively renovated over the years, spanning a total of 99,500 square feet across three floors. The building’s spacious lobby enters a dramatic two-story atrium with an impressive, oversized skylight and brick and beam finishes, creating a welcoming atmosphere for clients and employees. Tenants have 24/7 access to the property, with card readers and video cameras for security. Centrally located at the heart of Cambridge, 1035 Cambridge Street situates tenants within an established hub near a wealth of quality urban amenities. The location is just a third of a mile from Union Square and Inman Square, both major commercial centers of the region with excellent restaurants and specialty stores. Offering convenient accessibility for commuters, the property sits just a short distance from major highways, including Highway 28 and Interstate 93. Providing additional access options, the site is a short walk from the Union Station Green Line stop, as well as several bus stops, and there are Zipcars and Hubway bikes on-site. Situated approximately 1 mile from both Harvard University and the Massachusetts Institute of Technology, businesses at 1035 Cambridge Street have access to one of the nation’s strongest talent pipelines, which can fuel future growth and expansion. When looking within just 1 mile of the property, tenants can tap into a sizable workforce of more than 68,000, with over 70% of locals carrying a bachelor’s degree or higher. Unlock premier office space at 1035 Cambridge Street, combining modern amenities, flexible layouts, and an unbeatable Cambridge location, with access to top talent, transportation, and vibrant commercial centers. Reach out to the Lee & Associates team today to schedule a tour and find the perfect space.

Date on Market:

2026-02-02

Watertown Office for Lease

Conveniently located in prime Watertown, MA, 66 Galen St is a newly built lab building offering 224,106 RSF with an expansion opportunity of up to 224,000 RSF in Phase II of the campus. Situated on a 5-acre campus plan, including 1 acre of lush green space, this building boasts LEED Gold Certification and approximately 25,000 SF of solar panels, aligning with your sustainability goals. Amenities abound, with a fitness center featuring locker rooms, an outdoor roof deck, and close proximity to biking and running trails.

Date on Market:

2024-03-21

Watertown Office for Lease

One of a kind warehouse/office hybrid space. Newton/Watertown line. Garden level. Needs cosmetics but well worth it at this price. Heat and hot water included. Perfect for light industrial, kinder garden, after school, office, etc. 7 parking can be included in rent. Don't miss this! Right off the mass pike highway. In the zone of major biotech development in Watertown Sq. Hard to find a better location or price in this prime area.

Date on Market:

2023-12-28

Cambridge Flex for Lease - E Cambridge/Kendall Sq

In 2021, Ownership completed a new façade on the building with the intention of completing the Lobby Renovation Project in Summer 2022. The Lobby Renovation will include a new at-grade accessible entrance, new freight elevator and stair column with access to the roof and a newly accessible Tenant Opportunity. This is the ideal time to coordinate with our Contractor to deliver your ideal lab space to Kendall Square.

Property Type:

Industrial

Date on Market:

2022-07-18

Boston Retail for Lease - Seaport

331-339 Northern Avenue is part of Innovation Square Phase III, a newly developed mixed-use project in Boston's Seaport District. The property offers retail leasing opportunities within a Class A environment designed to serve one of the region's most active employment and innovation hubs. Situated along Northern Avenue near Drydock Avenue, the location benefits from proximity to the Raymond L. Flynn Marine Park, major life science employers, waterfront destinations, and the broader Seaport business district. The development incorporates modern building design and a pedestrian-oriented setting that supports retail visibility and customer engagement. On-site amenities include a café, fitness center, conference and event facilities, outdoor seating areas, and a roof deck, creating a dynamic environment for employees, visitors, and customers. The surrounding neighborhood continues to attract leading life science, technology, and professional services organizations, generating a substantial daytime population and ongoing demand for neighborhood-serving retail concepts. The property also benefits from convenient access to Interstate 90, South Station, Logan International Airport, and the Port of Boston. Exceptional public transit connectivity and a highly walkable waterfront setting further enhance accessibility for customers and employees. The combination of new construction, modern amenities, and a location within one of Boston's most established innovation districts positions the property to accommodate a variety of retail and service-oriented users seeking visibility within the Seaport market.

Property Type:

Office

Date on Market:

2026-07-16

Boston Office for Lease - Longwood/Fenway

Located in the heart of Boston's iconic Fenway neighborhood, 98 Brookline Avenue offers an exceptional address at the intersection of business, innovation, and entertainment. Steps from Fenway Park, the property is surrounded by a vibrant mix of restaurants, cafés, hotels, fitness centers, and retail amenities. The location also provides convenient access to the MBTA Green Line, commuter rail, major highways, and Boston's renowned Longwood Medical Area, making it an ideal destination for employees, clients, and visitors alike.

Date on Market:

2026-07-13

Dedham Industrial for Lease - Route 1 South

105 Commerce Way has one loading Dock.

Date on Market:

2026-04-20

Cambridge Office for Lease - Mid-Cambridge/Harvard Sq

This office property is situated on Cambridge Street in the Wellington-Harrington neighborhood, offering a high-visibility address in the heart of Cambridge. The available suite features a functional layout with three private offices, a reception area, a kitchenette, and a private restroom, designed to complement professional and creative work environments. Natural light enhances the space, while the secured building ensures privacy and reliability for occupants. The location provides seamless accessibility via public transportation and is exceptionally walkable, with bike-friendly routes nearby. Tenants benefit from proximity to leading universities, medical facilities, and biotech firms that define Cambridge’s dynamic business ecosystem. Positioned within a well-connected district, the property serves as a strategic hub for companies seeking connectivity to Kendall Square, downtown Boston, and the broader Greater Boston market.

Date on Market:

2026-03-09

Newton Office, Retail for Lease - Newton/Brookline

Multiple spaces for lease ranging from 1,456 - 3,717 SF and 1,256 - 2,138 SF • Ground floor of a 173,000 SF office building leased to various institutional companies such as Clearview Healthcare Partners and Odysseys Unlimited. • Existing (shared) parking deck containing 344 spaces in addition to ample street parking and an abutting 67 space public parking lot • Ground-Level co-tenants include Pediatrics of Newton Wellesley, Corepower Yoga, Sola Salon and Thai Amarin • Located directly at the heavily trafficked confluence of the Massachusetts Turnpike, Washington Street and Centre Street • Positioned in the Newton Corner village of Newton, and directly engrained in the interior residential road network in addition to its ideal ingress/egress from various access points

Date on Market:

2026-06-03

Newton Office for Lease - Newton/Brookline

Located in the heart of Newton Corner, 275 Washington Street—commonly known as One Newton Place—is a prominent Class B, four-story office and retail building totaling approximately 173,000 square feet. Originally built in 1985 and renovated in 2005, the property offers a flexible mix of office and ground-floor retail space suited for professional, medical, and service-oriented tenants. The building features efficient floor plates, approximately 12-foot unfinished ceiling heights, and a strong on-site and nearby amenity base. Strategically positioned at the highly trafficked confluence of Washington Street, Centre Street, and the Massachusetts Turnpike (I-90), the property provides exceptional regional accessibility, including express bus service to Boston and convenient highway access. Tenancy includes a mix of established corporate, healthcare, and lifestyle users, contributing to a vibrant, walkable environment within one of Newton’s most connected commercial villages.

Date on Market:

2026-07-18

Boston Office for Lease - Seaport

Located in Boston’s vibrant Seaport District, 19 Fid Kennedy Avenue is part of The Foundry at Drydock, a premier Class A office building offering approximately 250,959 square feet of modern workspace. Built in 2022, this eight-story property features state-of-the-art design, controlled access security, and on-site staff, making it ideal for businesses seeking a dynamic and secure environment. The building includes biotech and lab-ready spaces, waterfront views, and easy access to public transportation, dining, and entertainment options, creating an inspiring setting for innovation and collaboration.

Date on Market:

2025-11-10

Boston Office, Retail for Lease - Seaport

Positioned in the heart of Boston’s Seaport Innovation District, 7 Channel Center presents a premier opportunity within the established Channel Center Planned Development Area. Surrounded by world-class companies, cultural amenities, and new development, the property is strategically located in one of Boston’s fastest-growing submarkets, driven by strong demand across office, life science, and residential sector

Date on Market:

2025-08-12

Boston Flex for Lease - Seaport

Date on Market:

2025-08-08

Cambridge Office for Lease - E Cambridge/Kendall Sq

Full building lab conversion completed in 2022, offering early stage biotech companies ready to go lab suites.

Date on Market:

2025-08-27

Charlestown Flex for Lease - Charlestown/East Boston

Brand New Lab, Heavy R&D, and Clean Room space with ability to modify as needed. Heavy Power, Loading, and other infrastructure available. Perfect space for Light Manufacturing, Electronics, Clean Room, and Advanced Manufacturing Groups.

Date on Market:

2025-05-12

Cambridge Office for Lease - E Cambridge/Kendall Sq

Date on Market:

2025-04-02

Boston Office for Lease - Seaport

10 World Trade is a 555,250 SF, 17-story premier life science and office development in Boston's thriving Seaport District. 10 World Trade will empower, connect, and inspire those who are shaping the future by leading the way in health, wellness, and environmentally sustainable, human-centered design. The development is fully-amenitized with a dramatic 45-foot tall atrium, a 150-seat auditorium built for the exchange of ideas, an indoor/outdoor oasis with operable glass walls, a cultural center with rotating exhibits and activations, and a skyline health club with a 300-meter track and a full suite of fitness offerings. From the eco-friendly redesign of World Trade Center Avenue to smart, energy-saving building features, 10 World Trade is unparalleled in its dedication to sustainability and wellness in a future-proof setting. Certifications include LEED Gold, WELL Gold, SITES Gold, WiredScore Platinum, and SmartScore Certified. 10 World Trade also offers 250 parking spaces at the South Boston Waterfront Transportation Center.

Date on Market:

2024-11-22

Charlestown Office for Lease - Charlestown/East Boston

Date on Market:

2026-05-05

Cambridge Office, Retail for Lease - Mid-Cambridge/Harvard Sq

The Abbot at 18-24 Brattle Street presents a once-in-a-generation opportunity to occupy the most iconic building in the heart of Harvard Square, the epicenter of Cambridge, Massachusetts. Future tenants are invited to discover the tremendous redevelopment potential of this iconic property through a blend of historic preservation with modern amenities. World-class academic institutions, top tech and life science companies, vibrant neighborhoods, and rich cultural diversity surround this dynamic property. Completely renovated from the inside out, suites on the second and fourth floors are immediately available for lease. The building's diverse tenant mix includes creative and professional businesses and national tenants, such as Starbucks, Cava, and F45 Training. Occupancy terms are negotiable, with lease rates available upon request. Building tenants enjoy state-of-the-art HVAC, private outdoor space, operable windows, and more. Historical and cultural offerings, cobblestone streets, and a unique blend of over 350 dining, retail, and entertainment options within a quarter-mile encompass The Abbot. This section of Cambridge is one of the most iconic locations in the market and one of the most accessible. Situated directly across the street from Harvard Square Red Line Station, the third-most active station in the area, tenants have access to over 23,000 daily riders. The Abbot boasts unparalleled traffic and amenities, making it a draw for customers, businesses, and retailers alike.

Date on Market:

2026-03-10

Cambridge Retail for Lease - Mid-Cambridge/Harvard Sq

The Abbot is the epicenter of Harvard Square. This iconic redevelopment is an irreplaceable world class retail and office destination in the heart of Harvard Square.

Property Type:

Office

Date on Market:

2026-03-17

Chelsea Office for Lease - Chelsea/Revere

Tons of area amenities within walking distance from the property. Highly attentive property management. Cost effective office space that Landlord is willing to build out for potential tenants to their required specs. Immediately accessible to the commuter train station, just one stop to North Station. Bus service to Wellington (orange), Haymarket (green) and Wonderland (blue) immediately accessible. Boston Logan International Airport just minutes away. Easy on/off Routes 1, 93 and 16.

Date on Market:

2026-08-14

Boston Office for Lease - Seaport

Seaport Circle is a mixed-use development featuring 650,000 square feet of life science research and office space in Boston's most prominent life science cluster. The project is pursuing LEED Platinum designation, with a 90% reduction in natural gas use. The two-tower design will provide flexible floor plates ranging from 25,000-75,000 square feet. In addition to state-of-the-art Class A lab and office space, the building will include best-in-class tenant amenity spaces and approximately 5,000 square feet of retail space. Seaport Circle will also include a 15,000 SF stand-alone South Boston Waterfront Job Training Pavilion (the Pavilion) with an ambitious mission focused on training for skilled jobs in life sciences and adding talent to the pipeline of opportunity in the Boston area’s exploding life science sector.

Date on Market:

2023-02-06