88 Life Science Properties for Lease in San Diego, CA, USA

San Diego Office for Lease - UTC

Discover what your teams could achieve in the heart of San Diego tech culture at Eastgate, the workplace for inventive minds. This 26-building campus redefines what's possible in La Jolla UTC, reimagining the workday with customizable spaces, sought-after amenities and unmatched location convenience. Recruit, retain and engage top talent with fitness, conferencing, sports courts and abundant outdoor enclaves for working and socializing in the open air. From move-in ready suites to full floors to full buildings, bring your company culture to life with personalized workspace, including the opportunity to develop a private, branded campus experience. Give your teams the convenience of 200+ elevated dining, shopping, wellness and entertainment options at Westfield UTC plus nearby beaches, luxury apartments, transportation and Torrey Pines Golf Course. Base your company in a fast-growing hub of life sciences and tech innovation among industry giants and access the local talent pipeline from UC San Diego and Scripps Research Institute. Lease with confidence from Irvine Company, San Diego’s locally trusted expert with 40+ years of homegrown expertise and exceptional customer care.

Date on Market:

2026-03-10

San Diego Flex for Lease - Scripps Ranch

Now available for lease, 10225 Willow Creek is a 75,119-square-foot multi-use building in Scripps Ranch. Ownership recently completed $4.75 million in building and site improvements, including a rooftop deck, hardscape and landscape, signage, and entrance facade improvements. 10225 Willow Creek has a slew of building specs to help with more efficient manufacturing productions. A new 4,000-amp electrical service was installed with all new transformers (480/277 volts) and switchgear. Plus, the site is permitted and ready for up to a 2-megawatt generator, pending tenant requirements. Along with the upcoming renovations, this project will be prepared to support mechanical units for lab and manufacturing use. The facility's clear height varies from 12- to 15-foot clearance, and may be able to accommodate some full building height (28-foot) uses. There are six dock-high positions served by two drive-in doors. Other site features include ample parking with 133 surface spots and 22 carport stalls, plus a hydraulic elevator installed in 2014. Located in the thriving Scripps Ranch submarket and surrounded by top talent, 10225 Willow Creek is neighbored by an array of corporate neighbors, including June Shine, Lockheed Martin, Iron Mountain, InnoTech Manufacturing, Apria, TechFlow, and Werfen. Drive times are desirable, as this modern building is just 14 minutes to Rancho Bernardo, 16 minutes to UTC (University Town Center), 20 minutes to Downtown and San Diego International Airport, and 25 minutes from Del Mar and La Jolla.

Date on Market:

2021-10-18

San Diego Flex for Lease - Sorrento Mesa

Capitalize on a rare opportunity to secure a premier ±20,000-square-foot facility at 10237 Flanders Court. This versatile property is currently experiencing unprecedented market demand, receiving 300x more exposure than typical listings with over 18,000 unique prospects in the last 30 days alone. Property Highlights: Versatile Layout: Approximately 20,000 SF of premium lab and office space, featuring recently updated flooring, fresh paint, and new ceilings for a true move-in-ready experience. Industrial Infrastructure: Boasting 18’+ clear height, two (2) grade-level doors, and robust power capabilities of 1,000 Amps at 480 Volts to support heavy R&D equipment. Superior Site Features: Situated on a spacious 2.57-acre lot with an expansive parking lot and included janitorial services for common areas. Strategic Location & Connectivity: Located in the epicenter of San Diego’s innovation hub, 10237 Flanders Court is surrounded by industry titans such as Qualcomm, Dexcom, Scripps Laboratories, and Inovio. Unmatched Access: Reach Interstate 805 in under five minutes, providing seamless connections to I-5 and the greater West Coast corridor (Los Angeles, San Francisco, and Seattle). Logistics Hub: Only 17 miles from San Diego International Airport, facilitating efficient national and international freight delivery. Talent & Innovation Pipeline: Position your company just 5 miles from the University of California San Diego (UCSD), tapping into a world-class pipeline of talent specializing in biology, computer science, and anatomy. The facility is supported by a elite labor force, with over 55,000 skilled professionals residing within a 10-mile radius, ensuring your operations are powered by the best in the industry.

Date on Market:

2026-01-22

La Jolla Office/Medical, Medical for Lease - UTC

La Jolla Medical Plaza is a mixed-use, healthcare-centric park that blends critical medical infrastructure with a robust on-site network, lifestyle amenities, and seamless access. A major difference-maker at La Jolla Medical Plaza is its roster of retailers and restaurants on the ground floors of two buildings. Staff and visitors have numerous cafés, healthy lunch spots, casual restaurants, and UTC Market at their doorstep. Multiple pharmacies, advanced imaging, a fitness center, and lab infrastructure are on the campus, plus on-site property management ensures a stress-free experience. Spec suites, second-generation build-outs, and customizable spaces await practitioners and professionals. Dental practices, outpatient clinics, orthopedic services, lab testing, dermatology, primary care, wellness clinics, and more will fit perfectly in the brimming medical environment here. 4180 La Jolla Village Drive uniquely stands as the tallest office high-rise in the vicinity, an excellent opportunity to assert a prominent presence with balconies available in some suites. 4120 La Jolla Village Drive is a freestanding surgery center that will be available soon for a turnkey takeover with FF&E. Scripps Memorial Hospital, VA Medical Center, and the University of California - San Diego’s School of Medicine, Science Research Park, and Jacobs Medical Center are all within 1.5 miles of the plaza. This proximity allows tenants to collaborate with cutting-edge organizations and attract talent from a renowned education system. La Jolla Medical Plaza’s positioning between Interstates 5 and 805 streamlines access to health-conscious patient pools, with two underground parking garages on campus affording stress-free drives for all.

Date on Market:

2026-03-27

San Diego Flex for Lease - Kearny Mesa

Exceptional opportunity to lease a highly improved freestanding building of 56,159 square feet in the most strategic location in all of San Diego, located in the heart of Kearny Mesa. Providing exceptional freeway and surface street access, this facility logistically from a business and quality of life perspective, is a home run. 4650 Overland Avenue is perfect for any flex, R&D, life science, lab, medical, and precision manufacturing applications. The interior has a mix of lab space, clean rooms, conference, private offices, open-plan bullpen areas, kitchen/lunchroom/lounge section, patios, and skylights. The warehouse space has numerous dock loading doors, great clear height, locker rooms, and showers. With a very distinctive architecture, this property creates an exceptional client and employee experience and energy that is unique and in a class of its own. All of this is supported by a robust HVAC and distribution system, multiple floor drains, waterlines, fully sprinklered areas, a backup diesel generator, a significant gas and air network, and a 4,000-amp, 277/480-volt power capacity, which can be cost-effectively expanded due to prior infrastructure preparation. The entire property can easily be enclosed, and a conduit is in place to install security gates. 4650 Overland Avenue is situated within the Spectrum Center, a very walkable and upscale neighborhood with a significant array of amenities within minutes. Multiple throughfares are proximate to the facility, including Interstates 15, 8, and 805, as well as the 163 and 52 freeways, which route into San Diego within a five-minute drive and extend into the Inland Empire and Los Angeles in under two hours. For easy connections to international and domestic markets, the San Diego International Airport is only 9.2 miles away. Don't miss out on a one-of-a-kind facility that can serve any manufacturing or distribution business long into the future, offering critical in-place infrastructure and flexible interior configurations that allow a business to scale and grow with its evolving operational requirements. This opportunity is perfect for an owner/user who is looking to expand their operation into a showstopping space.

Date on Market:

2025-05-01

La Jolla Office, Industrial for Lease

La Jolla Cove Research Center offers a rare opportunity to lease premier office and laboratory space in the heart of La Jolla’s vibrant coastal community. This five-story, elevator-served property provides a unique blend of professional office environments and specialized lab facilities, all within walking distance of the Village’s abundant amenities. Tenants enjoy breathtaking ocean views, a rooftop terrace, and executive office wings with private balconies, creating an inspiring work setting. The building is designed to support a wide range of uses, including office, medical, and laboratory operations, under LJ PD-5 zoning. Features include on-site management and maintenance, a back-up generator, autoclave and glass wash facilities, and vivarium spaces. A shared conference center and a 110-person amphitheater provide flexible meeting options for collaborative teams. With covered parking, proximity to major financial institutions, dining, and retail, and easy access to the scenic La Jolla coastline, this property combines functionality with an unmatched location. Biotech lab space for lease in La Jolla near UC San Diego. Coastal life science research facility in La Jolla Village. Plug-and-play wet laboratory suites with fume hoods. Research lab space with vivarium access in San Diego. Ocean view office and laboratory suites for biotech companies

Date on Market:

2026-03-11

San Diego Industrial for Lease - Mira Mesa/Miramar

Available for lease, 7740 Kenamar Court offers an opportunity to secure a ±33,715 SF industrial / flex facility on a ±1.67-acre parcel in the heart of Miramar’s core industrial corridor. The building features an efficient 50% warehouse / 50% office build-out, providing flexibility for a wide range of users including manufacturing, R&D, life science support, engineering, and distribution operations. Warehouse functionality is enhanced by 22–24’ clear heights, 1 dock-high door, 2 grade-level doors, and robust 3-phase power (1,600 amps, 277/480V) - capabilities increasingly difficult to find in infill Miramar assets. A fenced ±10,000 SF yard delivers secured outdoor storage and operational flexibility, while ±85 on-site parking spaces, with the ability to expand parking into the yard, support higher employee density or fleet requirements. The concrete tilt-up construction with glass curtain wall provides a strong corporate presence, ideal for headquarters users seeking both functionality and image. Zoned IL-2-1, the property benefits from long-term industrial land-use protections reinforced by the City of San Diego’s updated Mira Mesa Community Plan, supporting continued industrial relevance and operational certainty. Strategically located with immediate access to Miramar Road, I-805, I-15, and SR-52, the property offers excellent regional connectivity for employees, logistics, and executive access.

Property Type:

Flex

Date on Market:

2026-02-17

San Diego Medical for Lease - Sorrento Valley

Property Type:

Flex

Date on Market:

2026-01-28

San Diego Flex for Lease - Sorrento Mesa

Property Type:

Office

Date on Market:

2025-12-15

San Diego Office/Medical for Lease - Sorrento Mesa

Rare owner-user or investment opportunity — a free-standing building in Sorrento Mesa offering the flexibility to occupy all or a portion of the building Abundance of on-site parking and adjacent street parking Exceptional visibility and signage, expansive window line, and elevator-served Zoning allows for a mix of uses Ease of commute with central location, short distance to freeway, and nearby transit options Synergy with adjacent tenants - situated in San Diego’s technology, life science and pharmaceutical hub

Property Type:

Office

Date on Market:

2025-12-03

San Diego Office for Lease - Sorrento Mesa

Date on Market:

2025-09-11

San Diego Flex for Lease - Mira Mesa/Miramar

Date on Market:

2025-09-23

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-08-01

San Diego Flex for Lease - Mira Mesa/Miramar

• 22,930 SF Freestanding Building within an Association • Suite 100: 14,369 SF Available for Immediate Occupancy • Suite 150: 8,561 SF Leased Through February 2030 • Interior Renovation Work Underway! • Sale Price: $9,750,000 ($425.21/SF) • Association Fees: $19,500 annually ($0.07/SF monthly) • Lease Rate: $2.25/SF NNN • Operating Expenses: $0.58/SF • Parking: 7.8/1,000 (113 Stalls – 4.9/1,000 Non-Reserved, Onsite | 66 Stalls – 2.9/1,000 Non-Reserved, Common Area) • Electrical Service: Building Total: 1,000 Amp 277/480 Volt 3 Phase • Fire Sprinklered • Suite 100 Features: 2/3 Modern Office; 1/3 Production/Lab/Warehouse – Skylights in Production Area – Two Glass Panel Roll-Up Doors – 14’ Clear Height – Outstanding Window Line/Natural Light – Plumbing/Soil Lines in place for Wet Lab or other uses – Private Offices have Sidelight Windows – LED Lighting Throughout – Nicely Appointed Ground Floor Breakroom – Second Floor Coffee Bar • Parcel Size: 3.14 Acres; San Diego County • APN: 343-350-28-00 • Zoning: IL-2-1 • Highly Desirable Sorrento Mesa Submarket

Date on Market:

2025-07-17

San Diego Flex for Lease - Mira Mesa/Miramar

Property Type:

Industrial

Date on Market:

2025-06-10

San Diego Flex for Lease - Mira Mesa/Miramar

Date on Market:

2025-04-07

San Diego Industrial for Lease - Mira Mesa/Miramar

• ± 51,296 SF Industrial Building • Private offices, open work space and assembly areas • 24’-30’ clear height warehouse • Dock high, grade level and step van loading • Large secure fenced yard • Concrete driveways and yard • Heavy power 4,000a/277-480v • High speed fiber to building • Ten-ton crane available • Natural Gas Service • Building can be 100% climate controlled • Building has 4,258 SF bonus storage mezzanine

Date on Market:

2025-03-18

San Diego Office for Lease - Sorrento Mesa

Former biotech facility, excellent parking, new landscaping, building signage opportunities.

Date on Market:

2026-02-02

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-02-12

San Diego Office for Lease - Sorrento Mesa

Date on Market:

2025-11-19

San Diego Flex for Lease - Torrey Pines

Office and lab suites available with up to ~8,500 SF of contiguous space. Office suites range from ~100-300 SF each, while lab suites range from ~300-6,000 SF each.  Campus is abundant with amenities which include a conferencing center, cafeteria, gym, basketball court, tennis/pickleball courts, sand volleyball court, and lap pool. Secure campus perfect for incubator life science companies. • $100 broker touring bonus for qualified tours • Existing lab and office suites available for sublease • Campus setting with amenities • Abundant free parking available

Date on Market:

2026-04-01

San Diego Office for Lease - Sorrento Valley

Date on Market:

2024-06-05

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2026-02-05

San Diego Office for Lease - Rancho Bernardo

12395 World Trade Drive is a high image 35,253 SF freestanding flex building located less than one mile from the I-15 in one of San Diego County’s most sought-after markets. Rancho Bernardo is home to many defense, technology and life science companies including Apple, Northrop Grumman, General Atomics and Sony. The property is in close proximity to over 1.2 million SF of retail amenities.

Property Type:

Flex

Date on Market:

2024-05-08