83 Life Science Properties for Lease in San Diego, CA, USA

San Diego Office for Lease - UTC

Discover what your teams could achieve in the heart of San Diego tech culture at Eastgate, the workplace for inventive minds. This 26-building campus redefines what's possible in La Jolla UTC, reimagining the workday with customizable spaces, sought-after amenities and unmatched location convenience. Recruit, retain and engage top talent with fitness, conferencing, sports courts and abundant outdoor enclaves for working and socializing in the open air. From move-in ready suites to full floors to full buildings, bring your company culture to life with personalized workspace, including the opportunity to develop a private, branded campus experience. Give your teams the convenience of 200+ elevated dining, shopping, wellness and entertainment options at Westfield UTC plus nearby beaches, luxury apartments, transportation and Torrey Pines Golf Course. Base your company in a fast-growing hub of life sciences and tech innovation among industry giants and access the local talent pipeline from UC San Diego and Scripps Research Institute. Lease with confidence from Irvine Company, San Diego’s locally trusted expert with 40+ years of homegrown expertise and exceptional customer care.

Date on Market:

2026-03-10

San Diego Flex for Lease - Scripps Ranch

Now available for lease, 10225 Willow Creek is a 75,119-square-foot multi-use building in Scripps Ranch. Ownership recently completed $4.75 million in building and site improvements, including a rooftop deck, hardscape and landscape, signage, and entrance facade improvements. 10225 Willow Creek has a slew of building specs to help with more efficient manufacturing productions. A new 4,000-amp electrical service was installed with all new transformers (480/277 volts) and switchgear. Plus, the site is permitted and ready for up to a 2-megawatt generator, pending tenant requirements. Along with the upcoming renovations, this project will be prepared to support mechanical units for lab and manufacturing use. The facility's clear height varies from 12- to 15-foot clearance, and may be able to accommodate some full building height (28-foot) uses. There are six dock-high positions served by two drive-in doors. Other site features include ample parking with 133 surface spots and 22 carport stalls, plus a hydraulic elevator installed in 2014. Located in the thriving Scripps Ranch submarket and surrounded by top talent, 10225 Willow Creek is neighbored by an array of corporate neighbors, including June Shine, Lockheed Martin, Iron Mountain, InnoTech Manufacturing, Apria, TechFlow, and Werfen. Drive times are desirable, as this modern building is just 14 minutes to Rancho Bernardo, 16 minutes to UTC (University Town Center), 20 minutes to Downtown and San Diego International Airport, and 25 minutes from Del Mar and La Jolla.

Date on Market:

2021-10-18

San Diego Flex for Lease - Sorrento Mesa

Capitalize on a rare opportunity to secure a premier ±20,000-square-foot facility at 10237 Flanders Court. This versatile property is currently experiencing unprecedented market demand, receiving 300x more exposure than typical listings with over 18,000 unique prospects in the last 30 days alone. Property Highlights: Versatile Layout: Approximately 20,000 SF of premium lab and office space, featuring recently updated flooring, fresh paint, and new ceilings for a true move-in-ready experience. Industrial Infrastructure: Boasting 18’+ clear height, two (2) grade-level doors, and robust power capabilities of 1,000 Amps at 480 Volts to support heavy R&D equipment. Superior Site Features: Situated on a spacious 2.57-acre lot with an expansive parking lot and included janitorial services for common areas. Strategic Location & Connectivity: Located in the epicenter of San Diego’s innovation hub, 10237 Flanders Court is surrounded by industry titans such as Qualcomm, Dexcom, Scripps Laboratories, and Inovio. Unmatched Access: Reach Interstate 805 in under five minutes, providing seamless connections to I-5 and the greater West Coast corridor (Los Angeles, San Francisco, and Seattle). Logistics Hub: Only 17 miles from San Diego International Airport, facilitating efficient national and international freight delivery. Talent & Innovation Pipeline: Position your company just 5 miles from the University of California San Diego (UCSD), tapping into a world-class pipeline of talent specializing in biology, computer science, and anatomy. The facility is supported by a elite labor force, with over 55,000 skilled professionals residing within a 10-mile radius, ensuring your operations are powered by the best in the industry.

Date on Market:

2026-01-22

La Jolla Office/Medical for Lease - UTC

La Jolla Medical Plaza is a purpose-built, healthcare-driven campus designed to support a full spectrum of outpatient medical uses. The project integrates essential clinical infrastructure with a highly curated on-site ecosystem, creating an efficient and patient-friendly environment for both providers and visitors. The campus is anchored by a strong concentration of medical services, including multiple pharmacies, advanced imaging, laboratory facilities, and a freestanding surgery center, delivering true operational synergy for healthcare users. On-site property management further supports seamless day-to-day operations, allowing providers to remain focused on patient care. Leasing opportunities range from spec suites and second-generation medical build-outs to fully customizable spaces, accommodating a wide range of specialties, including surgical, orthopedic, primary care, dermatology, dental, and wellness practices. 4120 La Jolla Village Drive offers a rare turnkey surgery center opportunity with existing FF&E, while 4180 La Jolla Village Drive, the tallest medical office building in the immediate area, provides a highly visible presence with select suites featuring private balconies. Strategically located within 1.5 miles of Scripps Memorial Hospital, the VA Medical Center, and UC San Diego’s Jacobs Medical Center, School of Medicine, and research campus, the plaza benefits from direct adjacency to one of Southern California’s premier healthcare and life sciences clusters. This proximity enhances referral networks, recruitment, and collaboration opportunities. Positioned between Interstates 5 and 805, La Jolla Medical Plaza offers exceptional regional access for patients and staff, complemented by ample structured parking for a seamless arrival experience.

Date on Market:

2026-05-11

San Diego Flex for Lease - Kearny Mesa

Exceptional opportunity to lease a highly improved freestanding building of 56,159 square feet in the most strategic location in all of San Diego, located in the heart of Kearny Mesa. Providing exceptional freeway and surface street access, this facility logistically from a business and quality of life perspective, is a home run. 4650 Overland Avenue is perfect for any flex, R&D, life science, lab, medical, and precision manufacturing applications. The interior has a mix of lab space, clean rooms, conference, private offices, open-plan bullpen areas, kitchen/lunchroom/lounge section, patios, and skylights. The warehouse space has numerous dock loading doors, great clear height, locker rooms, and showers. With a very distinctive architecture, this property creates an exceptional client and employee experience and energy that is unique and in a class of its own. All of this is supported by a robust HVAC and distribution system, multiple floor drains, waterlines, fully sprinklered areas, a backup diesel generator, a significant gas and air network, and a 4,000-amp, 277/480-volt power capacity, which can be cost-effectively expanded due to prior infrastructure preparation. The entire property can easily be enclosed, and a conduit is in place to install security gates. 4650 Overland Avenue is situated within the Spectrum Center, a very walkable and upscale neighborhood with a significant array of amenities within minutes. Multiple throughfares are proximate to the facility, including Interstates 15, 8, and 805, as well as the 163 and 52 freeways, which route into San Diego within a five-minute drive and extend into the Inland Empire and Los Angeles in under two hours. For easy connections to international and domestic markets, the San Diego International Airport is only 9.2 miles away. Don't miss out on a one-of-a-kind facility that can serve any manufacturing or distribution business long into the future, offering critical in-place infrastructure and flexible interior configurations that allow a business to scale and grow with its evolving operational requirements. This opportunity is perfect for an owner/user who is looking to expand their operation into a showstopping space.

Date on Market:

2025-05-01

San Diego Industrial for Lease - Sorrento Valley

Date on Market:

2026-05-11

San Diego Industrial for Lease - Sorrento Valley

10835 Sorrento Valley Road is a strategically positioned, freestanding industrial facility within San Diego’s highly sought-after Sorrento Valley corridor. The property is distinguished by its rare low-coverage configuration, creating expansive secured yard space that enhances operational flexibility. A warehouse-centric design prioritizes high-bay functionality and efficient circulation through multiple loading points. Immediate access to Interstate 805, along with proximity to I-5 and Highway 56, enables strong regional connectivity and logistical efficiency. The site benefits from prominent freeway visibility and walkable access to the Sorrento Valley Coaster Station, supporting both branding and workforce accessibility. Surrounded by leading life science, technology, and research companies, the property sits within a premier corporate environment supported by robust infrastructure and proximity to San Diego’s most affluent residential communities.

Date on Market:

2026-04-07

La Jolla Office, Industrial for Lease

La Jolla Cove Research Center offers a rare opportunity to lease premier office and laboratory space in the heart of La Jolla’s vibrant coastal community. This five-story, elevator-served property provides a unique blend of professional office environments and specialized lab facilities, all within walking distance of the Village’s abundant amenities. Tenants enjoy breathtaking ocean views, a rooftop terrace, and executive office wings with private balconies, creating an inspiring work setting. The building is designed to support a wide range of uses, including office, medical, and laboratory operations, under LJ PD-5 zoning. Features include on-site management and maintenance, a back-up generator, autoclave and glass wash facilities, and vivarium spaces. A shared conference center and a 110-person amphitheater provide flexible meeting options for collaborative teams. With covered parking, proximity to major financial institutions, dining, and retail, and easy access to the scenic La Jolla coastline, this property combines functionality with an unmatched location. Biotech lab space for lease in La Jolla near UC San Diego. Coastal life science research facility in La Jolla Village. Plug-and-play wet laboratory suites with fume hoods. Research lab space with vivarium access in San Diego. Ocean view office and laboratory suites for biotech companies

Date on Market:

2026-04-13

San Diego Flex for Lease - Sorrento Valley

Date on Market:

2026-01-28

San Diego Flex for Lease - Sorrento Mesa

Property Type:

Office

Date on Market:

2025-12-15

San Diego Office/Medical for Lease - Sorrento Mesa

Rare owner-user or investment opportunity — a free-standing building in Sorrento Mesa offering the flexibility to occupy all or a portion of the building Abundance of on-site parking and adjacent street parking Exceptional visibility and signage, expansive window line, and elevator-served Zoning allows for a mix of uses Ease of commute with central location, short distance to freeway, and nearby transit options Synergy with adjacent tenants - situated in San Diego’s technology, life science and pharmaceutical hub

Property Type:

Office

Date on Market:

2025-12-03

San Diego Office for Lease - Sorrento Mesa

Date on Market:

2025-09-11

San Diego Flex for Lease - Mira Mesa/Miramar

Located in the sought-after Sorrento Mesa submarket, 6335 Ferris Square provides highly functional flex and laboratory space designed for life sciences and technology users. The property offers approximately 70% lab build-out and 30% office space, combined with full climate control, wet lab infrastructure, and enhanced HVAC systems to meet specialized operational needs. Existing improvements include fume hoods, chemical and hazardous material zones, a tissue culture suite, and dedicated shipping and receiving areas. Tenants benefit from a quiet, campus-like setting within a well-established biotech corridor, surrounded by a robust network of life science companies. Accessibility is a key strength, with immediate reach to Interstates 805, 5, and 15, ensuring strong regional connectivity. On-site, two grade-level doors and ample parking support logistical ease and convenience. Positioned within minutes of coastal amenities and regional thoroughfares, the property accommodates R&D, tech operations, and hybrid lab-office configurations for businesses focused on innovation and growth.

Date on Market:

2025-09-23

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-08-01

San Diego Flex for Lease - Mira Mesa/Miramar

• 22,930 SF Freestanding Building within an Association • Suite 100: 14,369 SF Available for Immediate Occupancy • Suite 150: 8,561 SF Leased Through February 2030 • Interior Renovation Work Underway! • Sale Price: $9,750,000 ($425.21/SF) • Association Fees: $19,500 annually ($0.07/SF monthly) • Lease Rate: $2.25/SF NNN • Operating Expenses: $0.58/SF • Parking: 7.8/1,000 (113 Stalls – 4.9/1,000 Non-Reserved, Onsite | 66 Stalls – 2.9/1,000 Non-Reserved, Common Area) • Electrical Service: Building Total: 1,000 Amp 277/480 Volt 3 Phase • Fire Sprinklered • Suite 100 Features: 2/3 Modern Office; 1/3 Production/Lab/Warehouse – Skylights in Production Area – Two Glass Panel Roll-Up Doors – 14’ Clear Height – Outstanding Window Line/Natural Light – Plumbing/Soil Lines in place for Wet Lab or other uses – Private Offices have Sidelight Windows – LED Lighting Throughout – Nicely Appointed Ground Floor Breakroom – Second Floor Coffee Bar • Parcel Size: 3.14 Acres; San Diego County • APN: 343-350-28-00 • Zoning: IL-2-1 • Highly Desirable Sorrento Mesa Submarket

Date on Market:

2025-07-17

San Diego Flex for Lease - Mira Mesa/Miramar

Property Type:

Industrial

Date on Market:

2025-06-10

San Diego Flex for Lease - Mira Mesa/Miramar

Date on Market:

2025-04-07

San Diego Office for Lease - Sorrento Mesa

Former biotech facility, excellent parking, new landscaping, building signage opportunities.

Date on Market:

2026-02-02

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2025-02-12

San Diego Office for Lease - Sorrento Mesa

Date on Market:

2025-11-19

San Diego Flex for Lease - Torrey Pines

Office and lab suites available with up to ~8,419 SF of contiguous space. Office suites range from ~140-2,890 SF, while lab suites range from ~330-8,500 SF.  Campus is abundant with amenities which include a conferencing center, cafeteria, gym, basketball court, tennis/pickleball courts, sand volleyball court, and lap pool. Secure campus perfect for incubator life science companies. • $100 broker touring bonus for qualified tours • Existing lab and office suites available for sublease • Campus setting with amenities • Abundant free parking available

Date on Market:

2026-04-13

San Diego Office for Lease - Sorrento Valley

Date on Market:

2024-06-05

San Diego Flex for Lease - Sorrento Mesa

Date on Market:

2026-02-05

San Diego Office for Lease - Kearny Mesa

8787 Complex Drive | 55,943 SF Office Building Located in Kearny Mesa, 8787 Complex Drive offers 55,943 SF of office space across four stories. Built in 1977 and renovated in 2014, the building features glass-walled offices, 12’ ceilings, and steel construction for a modern, open feel. With two elevators, and a wet sprinkler system, the property is well-equipped for multi-tenant use. Set on a 69,260 SF lot, it provides ample parking, freeway access, and nearby amenities in a walkable, transit-friendly location.

Date on Market:

2026-02-06