31 Life Science Properties for Lease in San Jose, CA, USA

Milpitas Flex for Lease

Situated in Milpitas, 688 Gibraltar Court is a research and development manufacturing building that has recently undergone extensive renovations, ensuring a modern and efficient workspace for businesses. With a substantial 2,000-amp 277/480-volt power panel, it offers robust electrical support for manufacturing and research needs. The presence of a backup generator ensures uninterrupted operations even during power outages. Furthermore, the building features a convenient double-door platform and a grade-level door, facilitating easy access and efficient logistics. In the bustling industrial hub of Milpitas, 688 Gibraltar Court boasts excellent connectivity via easy access to Highway 237, Interstate 680, Interstate 880, and Calaveras Boulevard. The property is conveniently located within walking distance of the new BART Milpitas Station, ensuring a seamless commute for administrative staff. Nearby amenities, including Big O Tires, Chick-fil-A, Safeway, Panda Express, McDonald's, and Starbucks, offer a variety of dining and service options for those passing through. This strategic industrial location can reach a population of approximately 8.5 million people in major cities like San Jose, San Francisco, Fresno, Los Angeles, San Diego, and Las Vegas, all within a day's drive. With its modern upgrades, powerful infrastructure, and exceptional location near major transit routes and amenities, 688 Gibraltar Court stands out as a premier choice for businesses seeking a versatile and accessible R&D and manufacturing facility in Milpitas.

Date on Market:

2025-11-06

Milpitas Flex for Lease

Welcome to 1561 Buckeye Drive, a versatile commercial opportunity for businesses seeking a well-equipped facility for research and development (R&D), manufacturing, or light industrial operations. The 44,815-square-foot building spans a generous floor plan with expansive lab spaces designed for innovation and productivity. 1561 Buckeye Drive has a long list of key features that boost efficiency. This advantageous property boasts large, open-concept lab spaces, perfect for a variety of research and development activities. With ample room for workstations, equipment, and specialized setups, this space offers the flexibility needed for cutting-edge projects. The facility's strategically positioned roll-up doors provide easy access for deliveries and shipments, while multiple loading docks ensure smooth logistics operations. The property has modern amenities, including 16-foot, 8-inch ceilings and 2,000-amp, 120/480-volt, 3-phase heavy power. Finally, this site is zoned to accommodate a wide range of industrial and commercial uses. Strategically situated in the heart of Milpitas, California, 1561 Buckeye Drive benefits from its proximity to major highways, including Interstate 880, offering seamless access to Silicon Valley, transportation hubs, and the greater Bay Area. Whether a business is developing new technology, expanding operations, or creating custom products, 1561 Buckeye Drive provides the flexibility to meet needs.

Date on Market:

2025-01-08

San Jose Office for Lease - South San Jose

Located at 6399 San Ignacio Avenue in San Jose, California, this premium Class A top-floor office space offers a rare opportunity to lease in one of Silicon Valley’s most sought-after commercial corridors. The property features a modern two-story office building totaling 41,831 square feet situated on a spacious ±2.5-acre site. Recently renovated in 2023, the building showcases a sleek design with huge windows that allow natural light to flow through, a welcoming lobby, and energy-efficient LED lighting. 6399 San Ignacio Avenue is fully occupied except for this available second-floor suite. The first floor is leased to a premier hospital medical office tenant undergoing new buildouts scheduled for April 2026. The second floor is home to a semiconductor design company, a marketing agency, and a software firm, creating a professional environment. Tenants will enjoy ample on-site parking with 134 ADA-compliant surface spaces, suite door signage, and lobby directory signage for enhanced visibility. Strategically positioned at the corner of San Ignacio and Santa Teresa, the property offers excellent accessibility. Located one block from the Light Rail station, you’ll enjoy easy access to Highways 85 and 101, creating a reverse commute. The building is approximately 15 minutes from Norman Y. Mineta San Jose International Airport, offering regional and national connectivity. The surrounding area is affluent, with a median home value of $1,044,483, and boasts a highly educated population: 44% of residents within a 10-mile radius hold a college degree. San Jose continues to be a powerhouse in the tech industry, attracting top talent and investment. The city leads the nation in GDP growth, averaging 8.3% annually over the past decade, and remains a hub for venture capital and innovation, particularly in artificial intelligence. With proximity to multiple medical centers and a thriving business ecosystem, this office space provides an ideal setting for companies seeking a prestigious address in Silicon Valley and an employee-friendly reverse commute, enabling a work-life balance.

Date on Market:

2025-10-09

Milpitas Office for Lease

McCarthy Center is Silicon Valley’s best value–a newly refreshed campus with modern design, engaging amenities and flexible solutions for companies of all sizes. From move-in ready suites with flexible lease terms to full floors and buildings, a range of options in the 1.1 million SF, 19-building campus accommodate growing companies with office, R&D and lab space. Attract and retain top talent with a full suite of amenities and modern design, including bold entries and highly-visible signage. Take your workday outdoors for fresh air and inspiration in the 10+ outdoor workspaces ideal for connection and collaboration. Host company events, networking and happy hours in the event-ready conferencing space. Energize your day with craft coffee and fresh, made-to-order dishes from The Eatery. Position your business for success and put more of what matters within reach thanks to a convenient Silicon Valley location near Hwy 237 and I-880, resort-style living at North Park, and dining, retail and entertainment at McCarthy Ranch Marketplace.

Date on Market:

2026-05-07

Fremont Flex for Lease

This clean room and lab space features ISO7 and Class 10,000 specifications, offering a highly controlled environment ready for advanced operations. The space includes compressed air, CAT 6 wiring, and is fully plug-and-play for immediate functionality. Located within Bayside Business Park, the property boasts a desirable corner position with excellent glass lines for natural light. Additional features include dock and grade-level loading, with power currently being verified. LED improvements were completed on 2/28/29, and the property is available for direct lease at an asking rate of $2.15 per SF NNN. Contact us today to schedule a tour.

Property Type:

Industrial

Date on Market:

2026-04-23

Sunnyvale Office/Medical, Flex for Lease - Moffett Park

-Unit 2: 2,000± SF -Asking Rent: $3.50 PSF Gross -Existing eye wash station -Existing hood for chemical use -Multiple sinks -Chemical proof countertops -Comes with two private offices -Unit 1: 900± SF -Asking Rent: $3.50 PSF Gross -Plenty of cabinet space for lab equipment & chemical storage. -Two sinks. -Exhaust duct hookup available if needed. -Shared common area bathrooms. -Shared common area breakroom with fridge, sink & microwave. -Reception desk at entrance of building along with mail area. -24-hour security for this property. -Located near HWY 101 & 237.

Date on Market:

2026-04-13

San Jose Flex for Lease - South San Jose

6872 Santa Teresa Boulevard offers ±3,447 square feet of high-identity R&D flex space available for Sublease in San Jose, California. This modern facility features an impressive glass line, abundant natural light, and a professional image along Santa Teresa Boulevard. The office area boasts 10-foot ceilings and 9-foot doors with 2-foot sidelights, creating an open and inviting workspace. The manufacturing area is equipped with HVAC, VCT flooring, skylights, and painted walls, supporting a variety of business operations. With 200 amps at 120/208 volt, 3-phase power, and a grade-level loading door, the property is well-suited for flexible R&D, light manufacturing, or tech uses. The site is conveniently located near major thoroughfares, amenities, and public transportation, making it an ideal choice for businesses seeking a strategic Silicon Valley address.

Date on Market:

2025-12-05

San Jose Office for Lease - West San Jose

Welcome to 560 S Winchester Blvd, a premier Class A office building located in the heart of West San Jose, adjacent to the vibrant Santana Row. This six-story, 100,841 SF property offers a sophisticated and modern workspace with exceptional amenities and unbeatable access. Built in 2000 and LEED Gold certified, the building blends high-end finishes with sustainable design, making it ideal for forward-thinking businesses. With flexible leasing options including a 9,410 SF direct lease and a 17,132 SF plug-and-play sublease, tenants can enjoy a move-in-ready environment complete with high-end furnishings, conference rooms, labs, and wellness spaces.

Date on Market:

2025-10-28

San Jose Office for Lease - North San Jose

Metro Plaza is a three building, Class A office project located in North San Jose. Adjacent to Highways 87 and 101 with easy access to Interstates 280, 680, and 17/880. There is a convenient VTA Light Rail and bus stop adjacent to the Project. The Project is approximately two miles north of downtown San Jose. The Project features a common conference center, fitness center and secured bike storage/repair lab.

Date on Market:

2026-02-18

Fremont Flex for Lease

The property at 3754-3758 Spinnaker Ct, Fremont, CA 94538 is a flex industrial asset located in the highly desirable Bayside area of Fremont. Offering convenient access to major transportation routes including I-880, I-680, and Highway 237, the site is also just minutes from the Warm Springs BART station. The building features a mix of office and industrial space and is surrounded by a range of amenities such as the Bay Club Fitness Center, hotels, restaurants, and scenic walking and biking trails. This location is well-suited for businesses seeking a blend of functionality and lifestyle convenience.

Property Type:

Industrial

Date on Market:

2025-04-25

Milpitas Flex for Lease

720-740 S Milpitas Blvd is a multi-tenant flex building with excellent Access to Hwy 680, 880 and 237. The property sits close to numerous amenities and Milpitas BART Station. There is ample parking onsite (3.8/1000 parking available).

Date on Market:

2024-09-03

San Jose Office, Flex for Lease - South San Jose

302 Enzo Drive in San Jose offers flexible Office, R&D, and Life Science space for lease, ranging from approximately 3,872 to 23,359 square feet. This modern building features prominent signage with freeway visibility, a renovated lobby, and a variety of suite configurations to suit different business needs. Tenants benefit from robust infrastructure, including high power capacity, dock and grade loading, and a private freight elevator. The property’s location provides easy access to major amenities, parks, and trails, making it an ideal choice for companies seeking a dynamic and accessible workspace in Silicon Valley.

Date on Market:

2025-07-11

Milpitas Flex for Lease

Date on Market:

2024-06-17

San Jose Flex for Lease - North San Jose

Walking distance to light rail, retail amenties & lodging

Date on Market:

2024-05-01

San Jose Flex for Lease - North San Jose

Date on Market:

2026-01-15

San Jose Office for Lease - North San Jose

High Profile Building & Location. Hwy. 101 Marquee Signage. Designer level appointments surround. Perimeter offices with natural light. Large collaborative workspace with conference rooms and Kitchenette. Private baths, w/shower, 4/1,000 parking, near retail amenities with easy access to major freeways, main arteries and the San Jose International Airport.

Date on Market:

2023-09-14

Santa Clara Flex for Lease - North Santa Clara

Premier office complex located in the heart of Silicon Valley. The office complex was built in 1981 and was recently renovated in 2008.

Date on Market:

2020-01-22

San Jose Flex for Lease - South San Jose

- 2- Standalone Two-Story Buildings Totaling 184,713 SF - 3,000 KVA to Each Building - Close proximity to Hwy 101, Hwy 85, Monterey Road & Retail - Trane Tracer Building Management System - Existing Data Center - 1st Fl. 16’6” Slab to Deck Height - 3.5/1,000 Parking Ratio - Dock & Grade Level Loading - Combination of Open & Dropped-Ceiling - Significant Power Savings via Bloom Box Micro-Grid Energy System - 1 block to VTA Light Rail Station - Highway 85 Signage Visibility

Date on Market:

2021-12-13

Fremont Flex for Lease

Freestanding Advanced Manufacturing/R&D Building. Market Ready Work Complete!

Date on Market:

2021-12-13

San Jose Flex for Lease - North San Jose

Date on Market:

2025-05-20

Campbell Office, Office/Medical for Lease

Maximum contiguous 40,000 S. F. Great West Valley location. Near junction of 17 & 85. Not far from 280 and 101. Cross section Camden road in Silicon Valley. Walking distance to all amenities. Flexible Lease terms. Zoning and General Plan M1 (Light Industrial), Flexible Zoning that has Abundant Permitted and Conditional Uses. Office. Medical. Medical device company. Biotech. Clean room. R&D. Laboratory Lab space. Multiple clean rooms. Lots of power! Surgical center. Ambulatory surgery site. Animal surgical. Animal Hospital. Veterinary Care. Imaging center. Ortho Rehab center. Speciality center. High ceilings. Roll up doors. Shipping & Handling. Veterinary clinic. Veterinary hospital. Sports and Fitness use. Animal day care. Office General Industrial. Visible from highway 17. Signage for major tenant.

Date on Market:

2022-08-16

San Jose Office for Lease - North San Jose

Freestanding single-story office building located on Charcot Ave in San Jose between First Streer and Zanker Rd. The property had a major facelift in 2020 pushing it to be one of the nicest office space/flex buildings available. The property is highly visible with great street front presence, with signage and plenty of parking. The building was designed with maximum flexibility allowing for single or multi-tenant use. The General Commercial zoning allows office and educational uses with CUP. Six spaces are available for lease right away. Including one with a 2500 square foot Clean-Room with a rating of 10K. Please email sam.jalili@compass.com for NNN costs, and any other questions you might have.

Property Type:

Flex

Date on Market:

2020-07-03

San Jose Office for Lease - South San Jose

6140 Hellyer Avenue is a freestanding, single-story commercial property with 4,478 square feet of interior space. Built in 2006, it features 100% office buildout and a modern exterior with strong curb appeal. The building is situated in Hellyer Commons Industrial Park and is zoned Industrial Park (IP), offering a wide range of permitted and conditionally permitted business uses. The design emphasizes professional functionality with a balance of privacy and openness. Inside, you'll find multiple private offices, a large shared kitchen, open team workspaces, and common areas ideal for meetings or collaborative sessions. Optional furniture and tenant improvement packages allow new occupants to customize their environment with minimal hassle. This property stands out for its strategic location and ease of access. It's located just minutes from Highways 101 and 85, providing efficient connectivity throughout the Bay Area. The surrounding area is quiet, green, and offers a peaceful work atmosphere while maintaining proximity to South San Jose’s business districts, restaurants, and retail services. Key building features include: Fully built-out interior with drop ceilings, central HVAC, and private kitchen ADA-compliant design and restroom access Sprinkler system and emergency lighting Secure, single-entry layout for improved access control 36 dedicated surface parking spaces High-speed internet included Bike-friendly amenities and adjacent walking trails Energy-efficient construction with ample window coverage The IP zoning permits a wide range of businesses, including office users, clean-tech and R&D firms, biotech and pharmaceutical companies, and certain medical or therapeutic practices. Businesses seeking to operate as a medical office may apply for a Special Use Permit with the City of San Jose. Approval typically depends on the type of practice (e.g., non-surgical vs. surgical, patient traffic levels, equipment used). The building's layout and infrastructure support this kind of conversion. Whether you're seeking executive offices, research space, or clinical functionality, 6140 Hellyer offers a balanced environment with flexibility, location advantages, and move-in readiness. Reach out today to schedule a tour or request zoning compatibility guidance. Text, call, or email today: Piyush Kothary (408) 656-7643 Kothary@yahoo.com

Date on Market:

2025-07-21

Santa Clara Office, Flex for Lease - North Santa Clara

- Full-building available - Full Kitchen Ground Floor - First Floor 11’ Ceiling Height (Not Clear Height) - Second Floor 10’ to Ceiling Tile 3.000 Amps - Ground Floor Outdoor Patio - Elevator Cold Room in Warehouse - 4 Standard and 1 Accessible Bathroom - LED: 2/29/26 - 7 Cutouts for Roll Up Doors - 5 Showers on First Floor

Date on Market:

2024-11-21